{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T16:11:21Z","timestamp":1777479081223,"version":"3.51.4"},"reference-count":30,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clin Appl Thromb Hemost"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Heavy menstrual bleeding affects up to two thirds of women on oral anticoagulation. The rates of heavy menstrual bleeding, its impact on quality of life and associated risk factors in women attending anticoagulation clinics in South Africa are largely unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>A prospective cohort study was performed over an eight-month period in women on Warfarin (n\u2009=\u200930) and Rivaroxaban (n\u2009=\u200927) for a median [interquartile range] duration of 15.5 [78.0] months attending an anticoagulation clinic in Johannesburg, South Africa. Heavy menstrual bleeding was assessed over one menstrual cycle using the validated pictorial blood loss assessment charts (PBAC) and the menstrual bleeding questionnaire (MBQ).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In this population of predominantly African ethnicity, with a median age of 39 [8] years, 39 (68.4%) women experienced heavy menstrual bleeding, defined as a PBAC score of &gt;100. Median cycle length on anticoagulation and MBQ scores were significantly higher among women with a PBAC score of &gt;100 (p\u2009&gt;\u20090.05). Univariate analysis identified Rivaroxaban as a risk factor for heavy menstrual bleeding (OR 5.03, 95% CI 1.40\u201318.12). Heavy menstrual bleeding required treatment in 29 (74.4%) women which included management of iron deficiency, anti-fibrinolytics, modification of anticoagulation and hormonal contraception.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Heavy menstrual bleeding was associated with a considerable negative impact on quality of life. This was most significant for women on Rivaroxaban as compared to Warfarin. It is essential to monitor and appropriately treat heavy menstrual bleeding in at risk women on anticoagulant treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10760296241281366","type":"journal-article","created":{"date-parts":[[2024,8,30]],"date-time":"2024-08-30T04:19:36Z","timestamp":1724991576000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Incidence and Impact on Quality  of Life of Heavy Menstrual Bleeding  in Women on Oral Anticoagulant Therapy"],"prefix":"10.1177","volume":"30","author":[{"given":"Naseerah","family":"Hassan","sequence":"first","affiliation":[{"name":"Dept. of Molecular Medicine and Hematology, Charlotte Maxeke Johannesburg Academic Hospital, National Health Laboratory System Complex and University of the Witwatersrand, Johannesburg, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1534-2930","authenticated-orcid":false,"given":"Elise","family":"Schapkaitz","sequence":"additional","affiliation":[{"name":"Dept. of Molecular Medicine and Hematology, Charlotte Maxeke Johannesburg Academic Hospital, National Health Laboratory System Complex and University of the Witwatersrand, Johannesburg, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haroun","family":"Rhemtula","sequence":"additional","affiliation":[{"name":"Dept. of Obstetrics, Charlotte Maxeke Johannesburg Academic Hospital and University of the Witwatersrand, Johannesburg, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nolukholo","family":"Ncete","sequence":"additional","affiliation":[{"name":"Dept. of Molecular Medicine and Hematology, Charlotte Maxeke Johannesburg Academic Hospital, National Health Laboratory System Complex and University of the Witwatersrand, Johannesburg, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,8,30]]},"reference":[{"key":"bibr1-10760296241281366","doi-asserted-by":"publisher","DOI":"10.1182\/asheducation-2016.1.236"},{"key":"bibr2-10760296241281366","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2010.11.011"},{"key":"bibr3-10760296241281366","doi-asserted-by":"publisher","DOI":"10.1182\/hematology.2022000401"},{"key":"bibr4-10760296241281366","unstructured":"National Guideline A. National Institute for Health and Care Excellence: Clinical Guidelines. In Heavy Menstrual Bleeding (update) National Institute for Health and Care Excellence (UK). Copyright (c) NICE 2018, 2018."},{"key":"bibr5-10760296241281366","doi-asserted-by":"publisher","DOI":"10.1160\/TH16-11-0874"},{"key":"bibr6-10760296241281366","doi-asserted-by":"publisher","DOI":"10.1016\/j.tru.2021.100088"},{"key":"bibr7-10760296241281366","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2015.07.030"},{"key":"bibr8-10760296241281366","doi-asserted-by":"publisher","DOI":"10.1016\/j.rpth.2023.100072"},{"key":"bibr9-10760296241281366","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0197583"},{"key":"bibr10-10760296241281366","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.14003"},{"key":"bibr11-10760296241281366","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2022017101"},{"key":"bibr12-10760296241281366","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.13583"},{"key":"bibr13-10760296241281366","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-08-665927"},{"key":"bibr14-10760296241281366","doi-asserted-by":"publisher","DOI":"10.1016\/j.tru.2021.100068"},{"key":"bibr15-10760296241281366","doi-asserted-by":"publisher","DOI":"10.1111\/aogs.12292"},{"issue":"1","key":"bibr16-10760296241281366","first-page":"26","volume":"1","author":"Fernandez-Jimenez MC","year":"2020","journal-title":"Womens Health Rep"},{"key":"bibr17-10760296241281366","doi-asserted-by":"publisher","DOI":"10.1016\/j.contraception.2010.12.011"},{"key":"bibr18-10760296241281366","unstructured":"Deiker M, BAloyi SM, Coetzee, Haupt L. 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