{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T23:21:25Z","timestamp":1792106485666,"version":"4.4.0"},"reference-count":33,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"National Natural Science Foundation of China initiated supporting funds for the project","award":["No. 823002013"],"award-info":[{"award-number":["No. 823002013"]}]},{"DOI":"10.13039\/501100012245","name":"Science and Technology Planning Project of Guangdong Province","doi-asserted-by":"publisher","award":["2020B1111170011"],"award-info":[{"award-number":["2020B1111170011"]}],"id":[{"id":"10.13039\/501100012245","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clin Appl Thromb Hemost"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:p>\n                    The study aims to evaluate the prognosis and risk factors of sepsis-associated thrombocytopenia (SAT) among patients with coagulopathy, and to provide evidence of the relationship between adverse outcomes and potential risks. Patients with sepsis-associated coagulopathy were included in the study from January 2014 to December 2022. The primary outcome was sepsis-associated thrombocytopenia (platelet count less than 100 *10\n                    <jats:sup>9<\/jats:sup>\n                    \/L), which was evaluated by logistic regression models adjusted for demographic characteristics and comorbidities. Among patients in the SAT group, 54% developed severe SAT, while 16% of these patients recovered from thrombocytopenia. The in-hospital mortality rate was significantly higher in the SAT group compared to the non-SAT group (31% in SAT group vs 23.9% in non-SAT group, p\u2009=\u20090.029). Even after adjusting for age, gender, Charlson comorbidity, white blood cell, and Sequential Organ Failure Assessment score, the differences in mortality rate persisted (Odds Ratio 0.72, [95% Confidence Interval 0.52\u20130.92]). Correlation analyses revealed that prothrombin time (r\u2009=\u20090.08, p\u2009=\u20090.50), international normalized ratio (r\u2009=\u20090.08, p\u2009=\u20090.42), prothrombin activity (r\u2009=\u2009\u22120.06, p\u2009&gt;\u20090.999), D-dimer (r\u2009=\u2009\u22120.02, p\u2009&gt;\u20090.999), and inflammatory parameters such as C-reactive protein (r\u2009=\u2009\u22120.11, p\u2009=\u20090.37) were not significantly correlated with platelet counts. According to subgroup analyses, patients with lung infection complicated by SAT had slightly higher mortality (OR 0.66, [95% CI, 0.46 to 0.94]). Sepsis-associated coagulopathy indicates a subset of critical ill patients, with those experiencing thrombocytopenia at greater risk for in-hospital death compared to those without it.\n                  <\/jats:p>","DOI":"10.1177\/10760296241283166","type":"journal-article","created":{"date-parts":[[2024,9,16]],"date-time":"2024-09-16T02:47:46Z","timestamp":1726454866000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":16,"title":["Risk Factors of Sepsis-Associated Thrombocytopenia among Patients with Sepsis Induced Coagulopathy"],"prefix":"10.1177","volume":"30","author":[{"given":"Jia-Jia","family":"Cheng","sequence":"first","affiliation":[{"name":"Department of Intensive Care Unit, Yantai Affiliated Hospital of Binzhou Medical University, Yantai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-0978-730X","authenticated-orcid":false,"given":"Rong","family":"Liufu","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Intensive Care Unit, Guangdong Cardiovascular Institute, Guangdong Provincial Key Laboratory of South China Structural Heart Disease, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Zhuang","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Guangdong Cardiovascular Institute, Guangdong Provincial Key Laboratory of South China Structural Heart Disease, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miao-Yun","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Unit, The First Veterans Hospital of Guangdong Province, Guangzhou, 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