{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T16:11:42Z","timestamp":1777479102711,"version":"3.51.4"},"reference-count":13,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82101390"],"award-info":[{"award-number":["82101390"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82171297"],"award-info":[{"award-number":["82171297"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clin Appl Thromb Hemost"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Rivaroxaban, a direct Factor Xa inhibitor, is commonly used for cerebral venous thrombosis (CVT) correction. However, pharmacokinetic differences in Chinese may vary in sensitivity and tolerance, resulting in either insufficient or excessive anticoagulation. Herein, the optimizing dosages of rivaroxaban in Chinese patients with CVT were analyzed based on monitoring anti-Xa activity dynamically, to maintain therapeutic efficacy and reduce rivaroxaban-related bleeding.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A real-world cohort study was conducted involving 112 CVT patients in Xuanwu Hospital, from August 2021 through January 2024. Patients were grouped according to their doses of rivaroxaban use (5, 10, 15, and 20 mg daily) based on dynamic plasma anti-Xa activity monitored using the chromogenic anti-Xa assay. Plasma levels of anti-Xa activity reached the therapeutic range, bleeding events and the dosage of rivaroxaban among these groups were analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The ratios of the patients whose plasma anti-Xa levels reached the standard therapeutic level (0.3\u20130.7\u2005IU\/mL) between the cohorts less than 20 mg\/d and 20 mg\/d showed no statistical difference, and no significant disparities were observed among 5, 10, 15, and 20 mg\/d dose groups. There was a discernible increase in the proportion of patients with bleeding events in the 20 mg\/d group, even though the results did not reach a statistical difference. Meanwhile, in patients with bleeding events, their plasma anti-Xa levels could exceed 0.7\u2005IU\/mL.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Sensitivity and tolerance to rivaroxaban in Chinese may vary. Individualized therapy dosage under the guidance of anti-Xa activity monitoring may not only guarantee anticoagulation effect, but also reduce rivaroxaban-related bleeding events.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10760296241286507","type":"journal-article","created":{"date-parts":[[2024,9,24]],"date-time":"2024-09-24T12:05:46Z","timestamp":1727179546000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Anti-Xa Activity Monitoring for Optimizing Rivaroxaban Dosage in Chinese Patients with Cerebral Venous Thrombosis"],"prefix":"10.1177","volume":"30","author":[{"given":"Xiaoming","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, 100053, China"},{"name":"Advanced Center of Stroke, Beijing Institute for Brain Disorders, Beijing, 100053, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meini","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, 100053, China"},{"name":"Advanced Center of Stroke, Beijing Institute for Brain Disorders, Beijing, 100053, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Duo","family":"Lan","sequence":"additional","affiliation":[{"name":"Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, 100053, China"},{"name":"Advanced Center of Stroke, Beijing Institute for Brain Disorders, Beijing, 100053, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhongao","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, 100053, China"},{"name":"Advanced Center of Stroke, Beijing Institute for Brain Disorders, Beijing, 100053, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kun","family":"Fang","sequence":"additional","affiliation":[{"name":"Capital Medical University, Beijing, 100069,China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiangyu","family":"Ren","sequence":"additional","affiliation":[{"name":"Capital Medical University, Beijing, 100069,China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naiqi","family":"Liu","sequence":"additional","affiliation":[{"name":"Capital Medical University, Beijing, 100069,China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Da","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, 100053, China"},{"name":"Advanced Center of Stroke, Beijing Institute for Brain Disorders, Beijing, 100053, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xunming","family":"Ji","sequence":"additional","affiliation":[{"name":"Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, 100053, China"},{"name":"Advanced Center of Stroke, Beijing Institute for Brain Disorders, Beijing, 100053, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1190-4710","authenticated-orcid":false,"given":"Ran","family":"Meng","sequence":"additional","affiliation":[{"name":"Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, 100053, China"},{"name":"Advanced Center of Stroke, Beijing Institute for Brain Disorders, Beijing, 100053, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,9,24]]},"reference":[{"key":"bibr1-10760296241286507","doi-asserted-by":"publisher","DOI":"10.1177\/2396987317719364"},{"issue":"2","key":"bibr2-10760296241286507","doi-asserted-by":"crossref","DOI":"10.1378\/chest.11-2292","volume":"141","author":"Ageno 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