{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T16:11:49Z","timestamp":1777479109813,"version":"3.51.4"},"reference-count":28,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Fujimori Kogyo Co"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clin Appl Thromb Hemost"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:p>The Total Thrombus-formation Analysis System (T-TAS) is an automated device using coated microchips to assess thrombus formation under flow conditions. Its value to monitor coagulation function in patients under antiplatelet therapy awaits further clarification. This study evaluated T-TAS to detect response to dual antiplatelet therapy (DAPT) in patients with peripheral artery disease (PAD).<\/jats:p>\n                  <jats:p>T-TAS using the platelet-chip (PL-chip) and atheroma-chip (AR-chip) was performed in 60 patients with PAD on the day after lower extremity revascularization. Results were compared with light transmission aggregometry (LTA) and multiple electrode aggregometry (MEA, ADP- and ASPI-test). To determine T-TAS reference ranges, 30 healthy blood donors were enrolled.<\/jats:p>\n                  <jats:p>The area under the curve of the PL-chip (AUC-PL) was outside the reference range in 91.2% and AUC-AR in 21.1% of the PAD patients. Low responders in MEA ASPI, MEA ADP or both tests and low responders in LTA induced by ADP had a significantly higher AUC-PL compared to responders (204 vs 70, p\u2009=\u2009.016 and 140 vs 32, p\u2009&lt;\u2009.001), respectively. Median AUC-PL in low responders in LTA and MEA, LTA or MEA and in responders in LTA and MEA was 301, 104 and 32 (p\u2009=\u2009.001), respectively. Our results suggest that the PL-chip can continuously assess the level of response to DAPT and might be helpful to monitor PAD patients.<\/jats:p>","DOI":"10.1177\/10760296241301412","type":"journal-article","created":{"date-parts":[[2024,11,22]],"date-time":"2024-11-22T03:09:23Z","timestamp":1732244963000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Total Thrombus-Formation System  in Patients with Peripheral Artery Disease"],"prefix":"10.1177","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0485-7402","authenticated-orcid":false,"given":"Christian","family":"Pfrepper","sequence":"first","affiliation":[{"name":"Division of Hemostaseology, University of Leipzig Medical Center, Leipzig, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Careen","family":"Franke","sequence":"additional","affiliation":[{"name":"Division of Hemostaseology, University of Leipzig Medical Center, Leipzig, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Metze","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University of Leipzig Medical Center, Leipzig, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Weise","sequence":"additional","affiliation":[{"name":"Division of Hemostaseology, University of Leipzig Medical Center, Leipzig, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annelie","family":"Siegemund","sequence":"additional","affiliation":[{"name":"Division of Hemostaseology, University of Leipzig Medical Center, Leipzig, Germany"},{"name":"Medical ICU, University of Leipzig Medical Center, Leipzig, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roland","family":"Siegemund","sequence":"additional","affiliation":[{"name":"Medical ICU, University of Leipzig Medical Center, Leipzig, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1126-5763","authenticated-orcid":false,"given":"Martin","family":"Federbusch","sequence":"additional","affiliation":[{"name":"Institute for Laboratory Medicine, University of Leipzig Medical Center, Leipzig, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reinhard","family":"Henschler","sequence":"additional","affiliation":[{"name":"Institute for Transfusion Medicine, University of Leipzig Medical Center, Leipzig, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2345-756X","authenticated-orcid":false,"given":"Sirak","family":"Petros","sequence":"additional","affiliation":[{"name":"Division of Hemostaseology, University of Leipzig Medical Center, Leipzig, Germany"},{"name":"Medical ICU, University of Leipzig Medical Center, Leipzig, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuela","family":"Konert","sequence":"additional","affiliation":[{"name":"Department of Angiology, University of Leipzig Medical Center, Leipzig, Germany"},{"name":"Division of Angiology, Dr. Horst Schmidt Kliniken Wiesbaden, Wiesbaden, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,11,22]]},"reference":[{"key":"bibr1-10760296241301412","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehx095"},{"key":"bibr2-10760296241301412","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2017.07.065"},{"key":"bibr3-10760296241301412","doi-asserted-by":"publisher","DOI":"10.1177\/1076029619885184"},{"key":"bibr4-10760296241301412","doi-asserted-by":"publisher","DOI":"10.1007\/s10555-017-9677-x"},{"key":"bibr5-10760296241301412","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8183.2011.00670.x"},{"key":"bibr6-10760296241301412","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2011.04464.x"},{"key":"bibr7-10760296241301412","doi-asserted-by":"publisher","DOI":"10.1016\/j.mvr.2011.11.007"},{"key":"bibr8-10760296241301412","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-18-1236"},{"key":"bibr9-10760296241301412","doi-asserted-by":"publisher","DOI":"10.1111\/jth.13256"},{"key":"bibr10-10760296241301412","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.116.005263"},{"key":"bibr11-10760296241301412","doi-asserted-by":"publisher","DOI":"10.5551\/jat.49700"},{"key":"bibr12-10760296241301412","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.115.002744"},{"issue":"2","key":"bibr13-10760296241301412","first-page":"15","volume":"25","author":"Savcic 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