{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T16:56:54Z","timestamp":1790355414521,"version":"4.1.0"},"reference-count":36,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Shaoyang Science and Technology Plan Project","award":["2023ZD0106"],"award-info":[{"award-number":["2023ZD0106"]}]},{"name":"Scientific Research Project of Hunan Provincial Health Commission","award":["202211003190"],"award-info":[{"award-number":["202211003190"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clin Appl Thromb Hemost"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:p>The Knops blood group system is an independent blood group system recognized by International Society of Blood Transfusion (ISBT) in 1992, and latest time consisting of 13 antigens carried on a glycoprotein of 2489 amino acids and called the Complement C3b\/C4b Receptor 1 (CR1). Erythrocyte KN antigen was first reported in 1970, and CR1 is a protein coding gene that is a member of the receptors of complement activation (RCA) family and is located in the \u201ccluster RCA\u201d region of chromosome 1. CR1 is an important participant in the erythrocyte immune machinery and plays an major role in inhibiting complement activation, and polymorphisms in its expression have been closely associated with a variety of diseases, including systemic lupus erythematosus (SLE), malaria, Plasmodium falciparum malaria, Alzheimer's disease (AD) and leprosy. Antibodies to the Knops system usually do not bind to complement and do not cause a hemolytic reaction. However, anti-Knops antibodies can be detected in the serum of some pregnant women. Generally, however, they only test positive by direct antiglobulin test (DAT) and most of them do not cause hemolytic disease of the newborn (HDN). This article is a review of the progress of the Knops blood group system.<\/jats:p>","DOI":"10.1177\/10760296241309638","type":"journal-article","created":{"date-parts":[[2024,12,20]],"date-time":"2024-12-20T22:22:34Z","timestamp":1734733354000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["A Review of the Knops Blood Group  System"],"prefix":"10.1177","volume":"30","author":[{"given":"Xiaohui","family":"Ma","sequence":"first","affiliation":[{"name":"Cancer Center, The First Hospital of Jilin University, Changchun, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Blood Transfusion, The First Hospital of Jilin University, Changchun, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0627-2659","authenticated-orcid":false,"given":"Yan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Changchun Bioxun Biotechnology Limited Liability Company, Changchun, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingbo","family":"Li","sequence":"additional","affiliation":[{"name":"Tianjin Dexiang Biotechnology Co., Ltd, Tianjin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zhong","sequence":"additional","affiliation":[{"name":"Department of Blood Transfusion, The Central Hospital of Shaoyang, Shaoyang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,12,20]]},"reference":[{"key":"bibr1-10760296241309638","doi-asserted-by":"publisher","DOI":"10.1111\/vox.13361"},{"key":"bibr2-10760296241309638","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2022016504"},{"issue":"1","key":"bibr3-10760296241309638","first-page":"81","volume":"118","author":"Alattar AG","year":"2023","journal-title":"Vox Sang"},{"issue":"1","key":"bibr4-10760296241309638","first-page":"95","volume":"119","author":"Soudry A","year":"2024","journal-title":"Vox Sang"},{"issue":"1","key":"bibr5-10760296241309638","first-page":"94","volume":"119","author":"Tilley L","year":"2024","journal-title":"Vox Sang"},{"key":"bibr6-10760296241309638","doi-asserted-by":"publisher","DOI":"10.1084\/jem.173.5.1159"},{"key":"bibr7-10760296241309638","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.146.10.3502"},{"key":"bibr8-10760296241309638","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.1970.tb00720.x"},{"key":"bibr9-10760296241309638","doi-asserted-by":"publisher","DOI":"10.1002\/9781118493595.ch20"},{"key":"bibr10-10760296241309638","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0006705"},{"key":"bibr11-10760296241309638","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2018.03.037"},{"key":"bibr12-10760296241309638","doi-asserted-by":"publisher","DOI":"10.1042\/BSR20200321"},{"key":"bibr13-10760296241309638","doi-asserted-by":"publisher","DOI":"10.1111\/j.1423-0410.1992.tb01204.x"},{"key":"bibr14-10760296241309638","doi-asserted-by":"publisher","DOI":"10.1111\/vox.12717"},{"key":"bibr15-10760296241309638","doi-asserted-by":"publisher","DOI":"10.1111\/trf.15938"},{"key":"bibr16-10760296241309638","doi-asserted-by":"publisher","DOI":"10.1111\/trf.16039"},{"key":"bibr17-10760296241309638","doi-asserted-by":"publisher","DOI":"10.1111\/trf.17541"},{"key":"bibr18-10760296241309638","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V97.9.2879"},{"key":"bibr19-10760296241309638","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2016001867"},{"key":"bibr20-10760296241309638","doi-asserted-by":"publisher","DOI":"10.1159\/000491884"},{"key":"bibr21-10760296241309638","doi-asserted-by":"publisher","DOI":"10.21307\/immunohematology-2020-007"},{"key":"bibr22-10760296241309638","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2004.00615.x"},{"key":"bibr23-10760296241309638","doi-asserted-by":"crossref","unstructured":"Reid ME. Blood group systems. 3th ed. Elsevier Ltd; 2012; pp. 549\u2013566.","DOI":"10.1016\/B978-0-12-415849-8.00024-7"},{"key":"bibr24-10760296241309638","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2007.01077.x"},{"key":"bibr25-10760296241309638","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3148.2010.01023.x"},{"key":"bibr26-10760296241309638","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/725684"},{"key":"bibr27-10760296241309638","doi-asserted-by":"publisher","DOI":"10.1016\/j.blre.2018.01.003"},{"key":"bibr28-10760296241309638","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2008.09.026"},{"key":"bibr29-10760296241309638","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0897.2005.00318.x"},{"key":"bibr30-10760296241309638","doi-asserted-by":"publisher","DOI":"10.1111\/tme.12166"},{"key":"bibr31-10760296241309638","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.1992.tb06870.x"},{"key":"bibr32-10760296241309638","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2005.02681.x"},{"key":"bibr33-10760296241309638","doi-asserted-by":"publisher","DOI":"10.1590\/S1415-47572011005000051"},{"key":"bibr34-10760296241309638","doi-asserted-by":"publisher","DOI":"10.1016\/j.imlet.2004.07.007"},{"key":"bibr35-10760296241309638","doi-asserted-by":"publisher","DOI":"10.21307\/immunohematology-2018-017"},{"key":"bibr36-10760296241309638","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V89.3.1068"}],"container-title":["Clinical and Applied Thrombosis\/Hemostasis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10760296241309638","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/10760296241309638","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10760296241309638","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T14:04:59Z","timestamp":1777385099000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/10760296241309638"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":36,"alternative-id":["10.1177\/10760296241309638"],"URL":"https:\/\/doi.org\/10.1177\/10760296241309638","relation":{},"ISSN":["1076-0296","1938-2723"],"issn-type":[{"value":"1076-0296","type":"print"},{"value":"1938-2723","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1]]},"article-number":"10760296241309638"}}