{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T09:52:26Z","timestamp":1783072346335,"version":"3.54.6"},"reference-count":29,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clin Appl Thromb Hemost"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>this study aimed to investigate the efficacy of recombinant human thrombopoietin (rhTPO) in the treatment of sepsis-associated thrombocytopenia, and to evaluate its impact on coagulation function, inflammatory markers, platelet (Plt) count, and patient prognosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>a total of 144 patients with sepsis-associated thrombocytopenia, admitted to our hospital between 2022 and 2023, were selected for the study. The patients were randomly divided into two groups using a random number table: the control group (Group C, n\u2009=\u200972) and the research group (Group R, n\u2009=\u200972). The Group C received standard treatment, while the Group R received rhTPO in addition to standard care. We compared the general demographic data, Acute Physiology and Chronic Health Evaluation II (APACHE II) scores, coagulation parameters, serum levels of Toll-like receptor 4 (TLR4), interleukin-6 (IL-6), serum creatinine (SCr), tumor necrosis factor-alpha (TNF-\u03b1), Plt count, transfusion volume, treatment duration, incidence of complications, and mortality rates between the two groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>there were no significant differences in the general demographic characteristics between the two groups ( P\u2009&gt;\u20090.05). After treatment, the APACHE II scores in both groups significantly decreased, with a more pronounced reduction observed in the Group R. Coagulation function indicators, including activated partial thromboplastin time (APTT), fibrinogen (FIB), plasminogen activator inhibitor-1 (PAI-1), antithrombin III (AT-III), protein C, thrombomodulin (TM), and Plt factor 4 (PF4), showed greater improvement in the Group R compared to the Group C ( P\u2009&lt;\u20090.05). The serum levels of TLR4, IL-6, and TNF-\u03b1 in the Group R were significantly lower than those in the Group C ( P\u2009&lt;\u20090.05), whereas no significant difference in SCr levels was observed between the groups ( P\u2009&gt;\u20090.05). The Plt count in the Group R began to significantly increase on day 3 of treatment, and was consistently higher than that in the Group C on days 3, 5, and 7 ( P\u2009&lt;\u20090.05). The Group R required significantly fewer red blood cell transfusions compared to the Group C and did not require Plt suspension ( P\u2009&lt;\u20090.05). No significant differences were found between the groups in terms of mechanical ventilation time, intensive care unit (ICU) length of stay, and total hospital stay ( P\u2009&gt;\u20090.05). However, the ICU and overall hospital mortality rates were significantly lower in the Group R than in the Group C ( P\u2009&lt;\u20090.05). Multivariate logistic regression analysis indicated that rhTPO treatment was an independent protective factor for reducing mortality (OR = 0.475, P\u2009=\u20090.042).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>rhTPO treatment effectively improves coagulation function and inflammatory status in patients with sepsis-associated thrombocytopenia, increases Plt count, reduces transfusion requirements, and lowers mortality. These findings suggest that rhTPO has significant clinical application value in the management of this condition.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10760296251315173","type":"journal-article","created":{"date-parts":[[2025,2,4]],"date-time":"2025-02-04T02:46:52Z","timestamp":1738637212000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Efficacy and Safety of Recombinant Human Thrombopoietin (rhTPO) on Coagulation Function and Inflammatory Factors in the Treatment of Patients with Sepsis-Related Thrombocytopenia"],"prefix":"10.1177","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-3622-2373","authenticated-orcid":false,"given":"Huijuan","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Intensive Care Unit (ICU), First People's Hospital of Linping District, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Colorectal Surgery, First People's Hospital of Linping District, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"He","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Unit (ICU), First People's Hospital of Linping District, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,2,3]]},"reference":[{"issue":"1","key":"bibr1-10760296251315173","first-page":"577","volume":"37","author":"Liu YX","year":"2023","journal-title":"J Biol RegulHomeost Agents"},{"key":"bibr2-10760296251315173","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fgene.2020.00001","volume":"11","author":"Sun XR","year":"2020","journal-title":"Front 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