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An ominous turn in the pandemic is the evolving public health crisis emanating from persistent SARS-CoV-2 infection and its associated long-term impact. Long COVID or post\u2013COVID syndrome describes protean symptoms that persist at least 3 months after the onset of acute illness and last for at least 2 months in individuals with a history of confirmed SARS-CoV-2 infection. Long COVID has become a public health concern. Millions of infected individuals are now facing chronic multi-organ failures, including neuropsychiatric, cardiovascular, pulmonary, and kidney complications. In general, the cause of long COVID syndrome is unclear but factors such as prolonged activation of immune responses, and viral persistence triggering transcription dysregulation of genes associated with normal thrombotic disease may play a role in cardiovascular complications. Although inflammatory biomarkers are reported in other disorders, it remains unclear whether similar biomarkers are associated with cardiovascular manifestations following COVID. Medications such as sulodexide directed at glycocalyx and coagulation have demonstrated benefits for long COVID in smaller studies. Here, we describe the outcomes of the symposium on the underlying cardiovascular mechanisms of the long COVID.<\/jats:p>","DOI":"10.1177\/10760296251319963","type":"journal-article","created":{"date-parts":[[2025,2,13]],"date-time":"2025-02-13T03:10:26Z","timestamp":1739416226000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Cardiovascular Symposium on Perspectives  in Long COVID"],"prefix":"10.1177","volume":"31","author":[{"given":"Robert S.","family":"Dieter","sequence":"first","affiliation":[{"name":"Loyola University Stritch School of Medicine, Maywood, USA"},{"name":"VA Hines, IL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2901-0339","authenticated-orcid":false,"given":"Prakasha","family":"Kempaiah","sequence":"additional","affiliation":[{"name":"Loyola University Stritch School of Medicine, Maywood, USA"},{"name":"Loyola University Chicago, Maywood, IL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth G.","family":"Dieter","sequence":"additional","affiliation":[{"name":"Wheaton College, Wheaton, IL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Alcazar","sequence":"additional","affiliation":[{"name":"Loyola University Chicago, Maywood, IL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alfonso","family":"Tafur","sequence":"additional","affiliation":[{"name":"Endeavor Health, University of Chicago, Pritzker School of Medicine, Chicago, IL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2316-6348","authenticated-orcid":false,"given":"Grigoris","family":"Gerotziafas","sequence":"additional","affiliation":[{"name":"Sorbonne University, INSERM UMR_S_938, Saint-Antoine Research Center (CRSA), Team \u201cCancer, Vessels, Biology and Therapeutics\u201d (CaVITE), Group \u201cCancer \u2013 Angiogenesis \u2013 Thrombosis\u201d, University Institute of Cancerology (UIC), Saint Antoine University Hospital, Assistance Publique H\u00f4pitaux de Paris, Paris, France"},{"name":"Thrombosis and Haemostasis Center, Department of Obstetrics, Gynecology and Perinatal Medicine, I.M. 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