{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T16:13:09Z","timestamp":1777479189054,"version":"3.51.4"},"reference-count":41,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["A1515012665"],"award-info":[{"award-number":["A1515012665"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clin Appl Thromb Hemost"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Sepsis-Induced Coagulopathy (SIC) is common complications of sepsis in intensive care unit (ICU) patients. It has a significant impact on the prognosis of patients with sepsis and is an important cause of death. However, there is no evidence for the use of Argatroban in SIC anticoagulant therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>A retrospective study was conducted based on data collected from patients with sepsis from the Medical Information Mart for Intensive Care IV (MIMIC-IV) database. SIC patients were screened according to SIC scores formulated by the International Society of Thrombosis and Hemostasis. Propensity score matching was used to match patients who received Argatroban with patients who did not receive Argatroban. Cox regression analysis was used to explore the correlation between Argatroban and SIC prognosis, and the hazard ratio was calculated. Finally, Kaplan-Meier curve was used to compare the survival rate between the two groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Outcome<\/jats:title>\n                    <jats:p>\n                      After PSM, 108 patients who received Argatroban were matched with 108 patients who did not receive Argatroban. In terms of outcomes, Argatroban admission to ICU was associated with a higher risk of death 30 days after ICU admission for SIC patients (HR\u2009=\u20091.800; 95%CI: 1.064\u223c3.043;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u2009.043) correlation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Argatroban is not recommended for anticoagulant therapy in SIC patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10760296251326095","type":"journal-article","created":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T07:13:12Z","timestamp":1766733192000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Evaluation of Argatroban in Sepsis-Induced Coagulopathy: A Retrospective Study Based on MIMIC-IV Database"],"prefix":"10.1177","volume":"31","author":[{"given":"Jiaqi","family":"Tang","sequence":"first","affiliation":[{"name":"Guangdong Cardiovascular Institute"},{"name":"Guangdong Academy of Medical Sciences"},{"name":"Department of Critical Care Medicine, Guangdong Provincial People's Hospital Affiliated to Southern Medical University (Guangdong Province Academy of Medical Sciences), Guangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongguang","family":"Ding","sequence":"additional","affiliation":[{"name":"Emergency Department, Guangdong Provincial People's Hospital Affiliated to Southern Medical University (Guangdong Province Academy of Medical Sciences), Guangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiwei","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, Guangdong Provincial People's Hospital Affiliated to Southern Medical University (Guangdong Province Academy of Medical Sciences), Guangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3243-4199","authenticated-orcid":false,"given":"Hongke","family":"Zeng","sequence":"additional","affiliation":[{"name":"Guangdong Cardiovascular Institute"},{"name":"Guangdong Academy of Medical Sciences"},{"name":"Department of Critical Care Medicine, Guangdong Provincial People's Hospital Affiliated to Southern Medical University (Guangdong Province Academy of Medical Sciences), Guangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,12,25]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-024-07507-3"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13613-022-01093-7"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12185-021-03152-4"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13613-022-01093-7"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40560-023-00672-5"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.12-2112"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13063-023-07853-5"},{"issue":"6","key":"e_1_3_4_9_2","first-page":"5515","article-title":"Unfractionated heparin protects the protein C system against lipopolysaccharide-induced damage in vivo and in vitro","volume":"14","author":"Zhao D","year":"2017","unstructured":"Zhao D, Ding R, Liu Y, Yin X, Zhang Z, Ma X. Unfractionated heparin protects the protein C system against lipopolysaccharide-induced damage in vivo and in vitro. Exp Ther Med. 2017;14(6):5515\u20135522.","journal-title":"Exp Ther Med"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/jth.14578"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000005357"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-016-1415-1"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arcmed.2021.07.003"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-019-2587-2"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1177\/10760296231157766"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.14789\/jmj.JMJ24-0010-P"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1097\/MBC.0000000000001133"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000004787"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1177\/1460458218810760"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2018-028101"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41597-022-01899-x"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1080\/13543784.2022.2030312"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1111\/jth.14578"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1676610"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1177\/10760296231219249"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-024-09154-x"},{"key":"e_1_3_4_27_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13613-020-00704-5"},{"key":"e_1_3_4_28_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2023.1230854"},{"key":"e_1_3_4_29_2","doi-asserted-by":"publisher","DOI":"10.1097\/BSD.0000000000000932"},{"key":"e_1_3_4_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtho.2020.11.030"},{"key":"e_1_3_4_31_2","doi-asserted-by":"publisher","DOI":"10.3348\/kjr.2015.16.2.286"},{"key":"e_1_3_4_32_2","doi-asserted-by":"publisher","DOI":"10.20344\/amp.21080"},{"key":"e_1_3_4_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arcmed.2021.07.003"},{"key":"e_1_3_4_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtha.2022.10.022"},{"key":"e_1_3_4_35_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40635-015-0072-z"},{"key":"e_1_3_4_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/0049-3848(90)90110-X"},{"key":"e_1_3_4_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2014.08.010"},{"issue":"6","key":"e_1_3_4_38_2","first-page":"1076","article-title":"Antithrombin-independent thrombin inhibitors, but not direct factor Xa inhibitors, enhance thrombin generation in plasma through inhibition of thrombin-thrombomodulin-protein C system","volume":"106","author":"Furugohri T","year":"2011","unstructured":"Furugohri T, Sugiyama N, Morishima Y, Shibano T. Antithrombin-independent thrombin inhibitors, but not direct factor Xa inhibitors, enhance thrombin generation in plasma through inhibition of thrombin-thrombomodulin-protein C system. Thromb Haemost. 2011;106(6):1076\u20131083.","journal-title":"Thromb Haemost"},{"key":"e_1_3_4_39_2","doi-asserted-by":"publisher","DOI":"10.1177\/10760296231195089"},{"key":"e_1_3_4_40_2","doi-asserted-by":"publisher","DOI":"10.1097\/SHK.0000000000000727"},{"key":"e_1_3_4_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtha.2023.05.028"},{"key":"e_1_3_4_42_2","doi-asserted-by":"publisher","DOI":"10.3390\/jcm8050728"}],"container-title":["Clinical and Applied Thrombosis\/Hemostasis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10760296251326095","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/10760296251326095","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10760296251326095","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T14:05:06Z","timestamp":1777385106000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/10760296251326095"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":41,"alternative-id":["10.1177\/10760296251326095"],"URL":"https:\/\/doi.org\/10.1177\/10760296251326095","relation":{},"ISSN":["1076-0296","1938-2723"],"issn-type":[{"value":"1076-0296","type":"print"},{"value":"1938-2723","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10]]},"article-number":"10760296251326095"}}