{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T16:13:18Z","timestamp":1777479198568,"version":"3.51.4"},"reference-count":25,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,3,17]],"date-time":"2025-03-17T00:00:00Z","timestamp":1742169600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,3,17]],"date-time":"2025-03-17T00:00:00Z","timestamp":1742169600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82172190"],"award-info":[{"award-number":["82172190"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"The Young and Middle-aged Research Foundation of Wannan Medical College","award":["WK2023ZQN48"],"award-info":[{"award-number":["WK2023ZQN48"]}]},{"name":"Research Foundation of Science and Technology Bureau of Anhui Province","award":["201904a07020026"],"award-info":[{"award-number":["201904a07020026"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clin Appl Thromb Hemost"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:p>\n                    Clopidogrel is usually discontinued 5\u20137 days before elective surgery to reduce the risk of bleeding. However, the perioperative safety of patients receiving low-molecular-weight heparin (LMWH) bridging therapy or continuing clopidogrel therapy remains unknown. We identified patients who received clopidogrel for cardiovascular diseases and underwent elective surgery at a large central hospital in China between June 2022 and January 2024. The primary endpoints were perioperative blood transfusion events and bleeding-related reoperations. A total of 62 patients who received clopidogrel and underwent abdominal surgery were included in this study. Based on the preoperative clopidogrel therapy strategy, patients were categorised into three groups: the LMWH bridging group (clopidogrel withdrawal followed by LMWH bridging therapy for 5-7 days; n\u2009=\u200922), the no-bridging group (clopidogrel withdrawal for 5-7 days; n\u2009=\u200926), and the continued group (clopidogrel therapy maintained; n\u2009=\u200924). Perioperative blood transfusion rates were higher in the LMWH bridging and continued groups. However, there was not a significant distinction (\n                    <jats:italic toggle=\"yes\">P\u2009<\/jats:italic>\n                    =\u2009.197). Additionally, hospital stay length, bleeding-related reoperation, and 3-month mortality were similar across the groups\n                    <jats:italic toggle=\"yes\">(P\u2009<\/jats:italic>\n                    &gt;\u2009.05). No patients experienced myocardial infarction or stroke within 3 months post-procedure. Patients who received preoperative LMWH bridging therapy or continued clopidogrel therapy had a slightly higher risk of perioperative bleeding. These findings need to be confirmed by further randomised controlled trials.\n                  <\/jats:p>","DOI":"10.1177\/10760296251327594","type":"journal-article","created":{"date-parts":[[2025,3,17]],"date-time":"2025-03-17T12:37:16Z","timestamp":1742215036000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Clopidogrel Management in Abdominal Surgery: A Comparison of Perioperative Bleeding Risks with Low-Molecular-Weight Heparin Bridging, No-Bridging and Clopidogrel Continuation Strategies"],"prefix":"10.1177","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2183-9051","authenticated-orcid":false,"given":"Bangsheng","family":"Hu","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou, Jiangsu, China"},{"name":"Department of Anesthesiology, The First Affiliated Hospital of Wannan Medical College, Wuhu, Anhui, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junsheng","family":"Chen","sequence":"additional","affiliation":[{"name":", Hefei"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuai","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou, Jiangsu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3292-2897","authenticated-orcid":false,"given":"Zeping","family":"Dai","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, The First Affiliated Hospital of Wannan Medical College, Wuhu, Anhui, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ju","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou, Jiangsu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,3,17]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2024.12708"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2023.10.013"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2021.5244"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.acvd.2017.12.004"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehu285"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.11-2298"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.injury.2015.03.024"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arth.2023.11.012"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamasurg.2019.3136"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.119.007811"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.blre.2020.100733"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/8703627"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2015.05.036"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.2011.23"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1590\/S0004-282X2010000500019"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00380-022-02044-9"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1501035"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.55.5495"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.050316"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehx419"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-19-1109"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2021.0716"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1080\/17425255.2020.1814254"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/cpt.2526"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0042-1757898"}],"container-title":["Clinical 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