{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T20:52:46Z","timestamp":1793825566264,"version":"4.6.1"},"reference-count":21,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"the Zhejiang Traditional Chinese Medicine Science and Technology Project, Hangzhou, Zhejiang, China","award":["2022Z136"],"award-info":[{"award-number":["2022Z136"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clin Appl Thromb Hemost"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>This study aims to investigate the role of the total cholesterol to high-density lipoprotein cholesterol ratio (THR) in predicting carotid stenosis in patients with acute ischemic stroke (AIS), aiming to establish its clinical utility in risk assessment and therapeutic decision-making.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>180 patients with AIS and concomitant carotid stenosis were classified into three groups (classified as mild [&lt;50%], moderate [50-70%], or severe [\u226570%]) based on stenosis severity. These groups were compared to 180 healthy controls. Carotid stenosis was diagnosed in all participants using digital subtraction angiography, with the severity graded accordingly. THR and lipid profiles were analyzed within 24\u2005h of admission. Statistical analyses included ANOVA, ROC curve evaluation, and multivariate regression to determine THR's predictive performance for stenosis severity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>THR levels were significantly elevated in AIS patients versus controls (3.80\u2009\u00b1\u20091.07 vs 3.02\u2009\u00b1\u20090.67; p\u2009&lt;\u20090.05) and correlated with stenosis severity (mild: 3.22\u2009\u00b1\u20090.85; moderate:3.86\u2009\u00b1\u20090.91; severe: 4.33\u2009\u00b1\u20091.16; p\u2009&lt;\u20090.05). ROC analysis demonstrated robust diagnostic accuracy (AUC: 0.807; 95% CI: 0.744-0.870), with a cutoff of 4.15 yielding 81.1% sensitivity and 95.6% specificity for severe stenosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>THR is a cost-effective, independent biomarker for carotid stenosis severity in AIS; its clinical use improves risk stratification and guides personalized care.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10760296251367724","type":"journal-article","created":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T17:11:17Z","timestamp":1759165877000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["THR as a Novel Biomarker for Carotid Stenosis Severity in Acute Ischemic Stroke: Implications for Risk Stratification and Personalized Management"],"prefix":"10.1177","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-0959-3389","authenticated-orcid":false,"given":"Cong","family":"Wu","sequence":"first","affiliation":[{"name":"The Fourth School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-5046-9631","authenticated-orcid":false,"given":"Yi","family":"Lv","sequence":"additional","affiliation":[{"name":"Department of Emergency, Hangzhou Third People\u2019s Hospital, Hangzhou, Zhejiang, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Conghuan","family":"Wang","sequence":"additional","affiliation":[{"name":"Cerebrovascular Disease Department, Hangzhou Third People's Hospital, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changyang","family":"Zhong","sequence":"additional","affiliation":[{"name":"Cerebrovascular Disease Department, Hangzhou Third People's Hospital, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,9,29]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1177\/17474930211065917"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.30.12.2513"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1212\/CON.0000000000000840"},{"issue":"1","key":"e_1_3_3_5_2","first-page":"2478324","article-title":"Perfusion angiography in acute ischemic stroke","volume":"2016","author":"Scalzo F","year":"2016","unstructured":"Scalzo F, Liebeskind DS, Medicine MMI. Perfusion angiography in acute ischemic stroke. Comput Math Methods Med. 2016;2016(1):2478324.","journal-title":"Comput Math Methods Med."},{"key":"e_1_3_3_6_2","doi-asserted-by":"crossref","unstructured":"Mill\u00e1n J Pint\u00f3 X Mu\u00f1oz A et al. Lipoprotein ratios: physiological significance and clinical usefulness in cardiovascular prevention. Vasc Health Risk Manag. 2009;5:757-765.","DOI":"10.2147\/VHRM.S6269"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.4254\/wjh.v14.i4.791"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.6065\/apem.2019.24.1.41"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40001-024-01769-9"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2008.05.036"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.117.019653"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-023-01762-2"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/jdi.13118"},{"issue":"1","key":"e_1_3_3_14_2","first-page":"138","article-title":"Dyslipidemia and atherosclerosis","volume":"69","author":"Koba S","year":"2011","unstructured":"Koba S, Hirano T. Dyslipidemia and atherosclerosis. Nippon Rinsho. 2011;69(1):138-143.","journal-title":"Nippon Rinsho."},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(90)91257-7"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1089\/met.2017.0135"},{"issue":"6","key":"e_1_3_3_17_2","article-title":"Update on lipids, inflammation and atherothrombosis","volume":"105","author":"Badimon L","year":"2011","unstructured":"Badimon L, Storey RF, Vilahur G, et al. Update on lipids, inflammation and atherothrombosis. Thromb Haemostasis. 2011;105(S6):S34-S42.","journal-title":"Thromb Haemostasis."},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.2174\/0929867328666210921161711"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.115.306301"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1160\/TH05-08-0552"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.2147\/JIR.S425663"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.115.011164"}],"container-title":["Clinical and Applied Thrombosis\/Hemostasis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10760296251367724","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/10760296251367724","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10760296251367724","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T14:05:20Z","timestamp":1777385120000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/10760296251367724"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":21,"alternative-id":["10.1177\/10760296251367724"],"URL":"https:\/\/doi.org\/10.1177\/10760296251367724","relation":{},"ISSN":["1076-0296","1938-2723"],"issn-type":[{"value":"1076-0296","type":"print"},{"value":"1938-2723","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8]]},"article-number":"10760296251367724"}}