{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T16:15:08Z","timestamp":1777479308436,"version":"3.51.4"},"reference-count":23,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clin Appl Thromb Hemost"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Atrial fibrillation (AF) poses a substantial worldwide health concern, significantly increasing the risk of stroke and morbidity. Direct oral anticoagulants (DOACs) such as apixaban are recommended over vitamin K antagonists for the management of AF. However, the impact of thyroid abnormalities on DOACs, specifically apixaban in AF patients remains underexplored. Given the limited data, this study aims to evaluate the effectiveness and safety of apixaban in AF patients with uncontrolled hypothyroidism.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study was a retrospective cohort analysis that categorized patients into two sub-cohorts according to their hypothyroidism status at the time they began apixaban treatment: a control group (without hypothyroidism) and an active group (with uncontrolled hypothyroidism). The primary outcome assessed was the rate of thrombosis events following the initiation of apixaban, while bleeding, stroke, and venous thromboembolism (VTE) events were considered as secondary outcomes. Logistic regression analysis was performed, with a p-value of less than .05 deemed statistically significant.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 292 patients included, 51 had uncontrolled hypothyroidism, and 241 were in the control group. Both groups had a median age of 70 years, with predominantly female patients. Any thrombosis events were higher in the uncontrolled hypothyroidism at crude analysis (17.6% vs 8.4%; p-value\u2009=\u2009.04); as well as higher odds at regression analysis [aOR: 2.40, 95%CI 0.99-5.83; p-value\u2009=\u2009.05]. In addition, stroke and major bleeding events were significantly higher in the uncontrolled hypothyroidism group (aOR: 4.26, 95%CI 1.51-12.00; p-value\u2009=\u2009.006 and aOR: 6.21, 95%CI 1.73-22.19; p-value\u2009=\u2009.005, respectively). The rate of VTE events and minor bleeding did not differ significantly between the two groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The use of apixaban in patients with AF and uncontrolled hypothyroidism was linked to higher rates of thrombosis and major bleeding compared to those without known hypothyroidism. These findings highlight the need for further research through larger prospective studies in this often-overlooked population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10760296251371043","type":"journal-article","created":{"date-parts":[[2025,9,2]],"date-time":"2025-09-02T05:28:52Z","timestamp":1756790932000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Evaluation of the Clinical Outcomes of Apixaban Use in Patients with Atrial Fibrillation and Uncontrolled Hypothyroidism: A Real-world Evidence"],"prefix":"10.1177","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5547-2043","authenticated-orcid":false,"given":"Khalid","family":"Al Sulaiman","sequence":"first","affiliation":[{"name":"Pharmaceutical Care Department, King Abdulaziz Medical City, Riyadh, Saudi Arabia"},{"name":"College of Pharmacy, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia"},{"name":"Clinical Trial Management, King Abdullah International Medical Research Center, Riyadh, Saudi Arabia"},{"name":"Saudi Critical Care Pharmacy Research (SCAPE) Platform, Riyadh, \rSaudi Arabia"},{"name":"Saudi Society for Multidisciplinary Research Development and Education (SCAPE Society), Riyadh, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manal A","family":"Aljohani","sequence":"additional","affiliation":[{"name":"Pharmaceutical Care Department, King Abdulaziz Medical City, Riyadh, Saudi Arabia"},{"name":"College of Pharmacy, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia"},{"name":"Clinical Trial Management, King Abdullah International Medical Research Center, Riyadh, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdullah F","family":"Alharthi","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy, College of Pharmacy, Shaqra University, Al-Dawadmi, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hisham A","family":"Badreldin","sequence":"additional","affiliation":[{"name":"Pharmaceutical Care Department, King Abdulaziz Medical City, Riyadh, Saudi Arabia"},{"name":"College of Pharmacy, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia"},{"name":"Clinical Trial Management, King Abdullah International Medical Research Center, Riyadh, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammed Y","family":"Alzahrani","sequence":"additional","affiliation":[{"name":"Pharmaceutical Care Department, King Abdulaziz Medical City, Riyadh, Saudi Arabia"},{"name":"College of Pharmacy, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia"},{"name":"Clinical Trial Management, King Abdullah International Medical Research Center, Riyadh, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rahaf A","family":"Alqahtani","sequence":"additional","affiliation":[{"name":"Pharmaceutical Care Department, King Abdulaziz Medical City, Riyadh, Saudi Arabia"},{"name":"Clinical Trial Management, King Abdullah International Medical Research Center, Riyadh, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Walaa A","family":"Alshahrani","sequence":"additional","affiliation":[{"name":"College of Pharmacy, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia"},{"name":"Saudi Critical Care Pharmacy Research (SCAPE) Platform, Riyadh, \rSaudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatimah M","family":"Abudayah","sequence":"additional","affiliation":[{"name":"Faculty of Nursing, King Abdulaziz University, Jeddah, \rSaudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad S","family":"Shawaqfeh","sequence":"additional","affiliation":[{"name":"College of Pharmacy, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia"},{"name":"Clinical Trial Management, King Abdullah International Medical Research Center, Riyadh, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed A","family":"Alrashed","sequence":"additional","affiliation":[{"name":"Administration of Pharmaceutical Services, Main Hospital, King Fahad Medical City, Riyadh, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alaa M","family":"Alenazi","sequence":"additional","affiliation":[{"name":"Pharmaceutical Care Department, King Abdulaziz Medical City, Riyadh, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nouf S","family":"Alsagri","sequence":"additional","affiliation":[{"name":"Pharmaceutical Care Department, King Abdulaziz Medical City, Riyadh, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammed Yahya","family":"Asiri","sequence":"additional","affiliation":[{"name":"Pharmaceutical Care Department, King Abdulaziz Medical City, Riyadh, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zayed","family":"Asiri","sequence":"additional","affiliation":[{"name":"Pharmaceutical Care Department, King Abdulaziz Medical City, Riyadh, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sulaiman","family":"Aljarallah","sequence":"additional","affiliation":[{"name":"Pharmaceutical Care Department, King Abdulaziz Medical City, Riyadh, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yusuf M.","family":"Garwan","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice, College of Clinical Pharmacy, Imam Abdulrahman Bin Faisal University, Dammam, Saudi 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