{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T16:15:08Z","timestamp":1777479308567,"version":"3.51.4"},"reference-count":22,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Bayer SA"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clin Appl Thromb Hemost"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>A prospective, randomized, multicenter study compared rivaroxaban 2.5\u2005mg twice daily plus aspirin 100\u2005mg once daily against aspirin 100\u2005mg once daily alone in patients with peripheral artery disease and intermittent claudication. The study demonstrated that rivaroxaban plus aspirin improved total walking distance. A better comprehension of coagulation and inflammatory biomarkers could serve as a prognostic indicator and inform clinical decision-making.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This is a subsequent biomarker analysis, including 36 patients from both arms and plasma from healthy controls. We used human plasma for comparison purposes of the baseline biomarkers for normality testing. Plasma levels of biomarkers relating to coagulation activation (DD, vWF, thrombin generation potential (TGP), fibrinolysis (PAI-1, TAFI) and inflammation (CRP) were assessed at baseline (day 0) and measured after 24 weeks.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Samples from 16 patients allocated to the aspirin plus rivaroxaban group and 20 from the aspirin alone group were collected. No significant differences were observed in biomarkers between patients receiving rivaroxaban plus aspirin and those receiving aspirin alone.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>There were no differences in coagulation or inflammatory biomarkers in patients with intermittent claudication treated with either rivaroxaban plus aspirin or aspirin alone.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10760296251372934","type":"journal-article","created":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T18:53:33Z","timestamp":1761245613000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Biomarker Analysis from the Compass Claudication Study \u2013 Rivaroxaban for Intermittent Claudication"],"prefix":"10.1177","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6072-4439","authenticated-orcid":false,"given":"Karen Falc\u00e3o","family":"Britto","sequence":"first","affiliation":[{"name":"Santa Casa de S\u00e3o Paulo School of Medical Sciences, S\u00e3o Paulo, \rSP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto Augusto","family":"Caffaro","sequence":"additional","affiliation":[{"name":"Santa Casa de S\u00e3o Paulo School of Medical Sciences, S\u00e3o Paulo, \rSP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuliano Giova","family":"Volpiani","sequence":"additional","affiliation":[{"name":"Santa Casa de S\u00e3o Paulo School of Medical Sciences, S\u00e3o Paulo, \rSP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2487-3052","authenticated-orcid":false,"given":"Maria Fernanda","family":"Portugal","sequence":"additional","affiliation":[{"name":"Hospital Israelita Albert Einstein"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samantha","family":"Neves","sequence":"additional","affiliation":[{"name":"Santa Casa de S\u00e3o Paulo School of Medical Sciences, S\u00e3o Paulo, \rSP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2627-1821","authenticated-orcid":false,"given":"Alexia","family":"Paganotti","sequence":"additional","affiliation":[{"name":"Santa Casa de S\u00e3o Paulo School of Medical Sciences, S\u00e3o Paulo, \rSP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6978-2798","authenticated-orcid":false,"given":"Felipe Menegueti","family":"Pereira","sequence":"additional","affiliation":[{"name":"Santa Casa de S\u00e3o Paulo School of Medical Sciences, S\u00e3o Paulo, \rSP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leandro Barile","family":"Agati","sequence":"additional","affiliation":[{"name":"Science Valley Research Institute"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6972-5830","authenticated-orcid":false,"given":"Camilla M.","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"Science Valley Research Institute"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Viviane Santana","family":"da Silva","sequence":"additional","affiliation":[{"name":"Science Valley Research Institute"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-7854-4814","authenticated-orcid":false,"given":"Emily","family":"Krupa","sequence":"additional","affiliation":[{"name":"Hemostasis & Thrombosis Research Laboratories at Loyola University Medical Centre"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabela Rodrigues","family":"Tavares","sequence":"additional","affiliation":[{"name":"Santa Casa de S\u00e3o Paulo School of Medical Sciences, S\u00e3o Paulo, \rSP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2219-7049","authenticated-orcid":false,"given":"Fakiha","family":"Siddiqui","sequence":"additional","affiliation":[{"name":"Program in Health Sciences, UCAM \u2013 Universidad Cat\u00f3lica San Antonio de Murcia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3465-2499","authenticated-orcid":false,"given":"Jawed","family":"Fareed","sequence":"additional","affiliation":[{"name":"Hemostasis & Thrombosis Research Laboratories at Loyola University Medical Centre"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valeria Cristina Resende","family":"Aguiar","sequence":"additional","affiliation":[{"name":"Hospital e Maternidade Christ\u00f3v\u00e3o da Gama, Grupo 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Laboratory markers quantifying prothrombin activation and actions of thrombin in venous and arterial thrombosis do not accurately assess disease severity or the effectiveness of treatment","volume":"96","author":"Ofosu FA","year":"2006","unstructured":"Ofosu FA. Review: Laboratory markers quantifying prothrombin activation and actions of thrombin in venous and arterial thrombosis do not accurately assess disease severity or the effectiveness of treatment. Thromb Haemost. 2006;96(5):568\u2013577. https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17080212","journal-title":"Thromb Haemost"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2018.03.008"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2018.08.002"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2016.263798"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.87.6.1915"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1160\/TH15-08-0620"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.16648"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1177\/009127002762491271"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/clc.23833"}],"container-title":["Clinical and Applied Thrombosis\/Hemostasis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10760296251372934","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/10760296251372934","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10760296251372934","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T14:05:21Z","timestamp":1777385121000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/10760296251372934"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":22,"alternative-id":["10.1177\/10760296251372934"],"URL":"https:\/\/doi.org\/10.1177\/10760296251372934","relation":{},"ISSN":["1076-0296","1938-2723"],"issn-type":[{"value":"1076-0296","type":"print"},{"value":"1938-2723","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8]]},"article-number":"10760296251372934"}}