{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T16:15:49Z","timestamp":1777479349003,"version":"3.51.4"},"reference-count":54,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clin Appl Thromb Hemost"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Portal venous thrombosis (PVT) is a serious complication in cirrhosis, with management debated due to differing anticoagulant guidelines. This network meta-analysis assessed various anticoagulants for PVT in cirrhotic patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>PubMed, Cochrane Central, and ScienceDirect were searched till May 2025. A frequentist network meta-analysis was conducted in RStudio version 4.3.3. The ranking was based on P-scores.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Nineteen studies were included in the analysis. Direct oral anticoagulants (DOACs) (RR\u2009=\u20092.38; 95%CI:[1.17, 4.85]; p\u2009=\u20090.02), fondaparinux (RR\u2009=\u200918.16; 95%CI:[2.09, 158.13]; p\u2009=\u20090.009), low-molecular-weight heparin (LMWH) (RR\u2009=\u200911.96; 95%CI:[1.58, 90.79]; p\u2009=\u20090.01), LMWH-Warfarin sequential therapy (RR\u2009=\u20092.32; 95%CI:[1.01, 5.31]; p\u2009=\u20090.04), and Vitamin K antagonists (VKA) (RR\u2009=\u20091.71; 95%CI:[1.03, 2.83]; p\u2009=\u20090.04) showed a significant increase in complete recanalization, with fondaparinux ranked highest (P-score\u2009=\u20090.94). DOACs (RR\u2009=\u20090.23;95%CI:[0.07, 0.71]; p\u2009=\u20090.01), LMWH (RR\u2009=\u20090.24;95%CI:[0.11, 0.52]; p\u2009=\u20090.0003), LMWH-Warfarin sequential therapy (RR\u2009=\u20090.40;95%CI:[0.21, 0.77]; p\u2009=\u20090.006) demonstrated a significant reduction in PVT progression, with Antithrombin-III ranked highest (P-score\u2009=\u20090.87). Fondaparinux was ranked highest (P-score\u2009=\u20090.90) for reducing esophageal variceal bleeding, while LMWH was ranked highest (P-score\u2009=\u20090.72) for decreasing overall bleeding. DOACs significantly decreased mortality (RR\u2009=\u20090.74; 95% CI: [0.67, 0.81]; p\u2009&lt;\u20090.0001), with LMWH ranked highest (P-score\u2009=\u20090.80) for mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>DOACs, LMWH, and LMWH-Warfarin sequential therapy significantly improved recanalization and reduced PVT progression. LMWH was ranked highest in reducing bleeding and mortality, while fondaparinux ranked highest regarding esophageal bleeding and complete recanalization.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10760296251405419","type":"journal-article","created":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T17:24:35Z","timestamp":1764955475000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Comparative Effectiveness and Safety of Various Anticoagulation Regimens for Portal Venous Thrombosis in Cirrhosis: A Systematic Review and Network Meta-Analysis"],"prefix":"10.1177","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-8990-7738","authenticated-orcid":false,"given":"Zain ul","family":"Abideen","sequence":"first","affiliation":[{"name":"Department of Medicine, King Edward Medical University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-4521-3256","authenticated-orcid":false,"given":"Muhammad Hassan","family":"Waseem","sequence":"additional","affiliation":[{"name":"Department of Medicine, Allama Iqbal Medical College"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noor Ul Huda","family":"Ramzan","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, UT Southwestern Medical Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hamna","family":"Raheel","sequence":"additional","affiliation":[{"name":"Department of Medicine, Dow University of Health Sciences"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fariha","family":"Hasan","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Cooper University Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2085-8739","authenticated-orcid":false,"given":"Pawan Kumar","family":"Thada","sequence":"additional","affiliation":[{"name":"Department of Medicine, Sotang Primary Hospital, Solukhumbu, Nepal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prasun K.","family":"Jalal","sequence":"additional","affiliation":[{"name":"Division of Abdominal Transplantation of the Michael E. 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