{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T16:16:06Z","timestamp":1777479366936,"version":"3.51.4"},"reference-count":19,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100003710","name":"Korea Health Industry Development Institute","doi-asserted-by":"crossref","award":["Not applicable"],"award-info":[{"award-number":["Not applicable"]}],"id":[{"id":"10.13039\/501100003710","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Ministry of Health and Welfare","award":["Not applicable"],"award-info":[{"award-number":["Not applicable"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clin Appl Thromb Hemost"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Hemogram is a novel biodegradable powdered hemostatic agent developed by binding calcium ions (Ca\u00b2\n                      <jats:sup>+<\/jats:sup>\n                      ) to carboxymethyl starch (CM-starch) and applying granulation technology to enhance blood absorption and hemostatic efficacy. This study aimed to evaluate the clinical efficacy and safety of Hemogram compared with the commercially available agent Arista\u2122 AH in patients undergoing gastrectomy.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This randomized controlled trial was conducted at Samsung Medical Center and included patients who experienced intraoperative oozing-type bleeding during gastrectomy. A total of 64 patients were enrolled and evenly randomized to receive either Hemogram (n\u2009=\u200932) or Arista\u2122 AH (n\u2009=\u200932) for local hemostasis. The primary efficacy endpoint was the hemostatic success rate within 5\u2005min. Secondary endpoints included hemostasis time, re-bleeding rate, number of hemostatic agent units used, transfusion volume, length of hospital stay, and incidence of adverse events.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Hemostatic success within 5\u2005min was achieved in 100% (32\/32) of the Hemogram group and 96.9% (31\/32) of the Arista\u2122 AH group, with no statistically significant difference between the two (P\u2009&gt;\u20090.05). The mean time to hemostasis was 1.25\u2009\u00b1\u20090.80\u2005min in the Hemogram group and 1.52\u2009\u00b1\u20090.85\u2005min in the Arista\u2122 AH group. No re-bleeding events were observed in the Hemogram group, while one case of re-bleeding (3.3%) was reported in the Arista\u2122 AH group. There were no significant differences between groups in terms of transfusion volume, length of hospitalization, or adverse event rates.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Hemogram demonstrated non-inferior hemostatic efficacy and safety compared to Arista\u2122 AH in patients undergoing gastrectomy. These findings suggest that Hemogram is a promising and clinically applicable hemostatic agent for surgical use.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10760296251405423","type":"journal-article","created":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T18:30:18Z","timestamp":1768588218000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical Evaluation of the Hemostatic Efficacy and Safety of a Biodegradable Hemostatic Agent, Hemogram: A Comparative Study with Arista\u2122 AH"],"prefix":"10.1177","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8830-4903","authenticated-orcid":false,"given":"Seung Ki","family":"Min","sequence":"first","affiliation":[{"name":"Sungkyunkwan University School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sung Eun","family":"Oh","sequence":"additional","affiliation":[{"name":"Sungkyunkwan University School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji Yeong","family":"An","sequence":"additional","affiliation":[{"name":"Sungkyunkwan University School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyun Kyoon","family":"Kim","sequence":"additional","affiliation":[{"name":"Theracion Biomedical Co., Ltd, Seongnam, Gyeonggi 13207, South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eun Jin","family":"Kim","sequence":"additional","affiliation":[{"name":"Theracion Biomedical Co., Ltd, Seongnam, Gyeonggi 13207, South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min-Gew","family":"Choi","sequence":"additional","affiliation":[{"name":"Sungkyunkwan University School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2026,1,16]]},"reference":[{"issue":"6","key":"e_1_3_2_2_2","article-title":"Impact of hemorrhage on trauma outcome: An overview of epidemiology, clinical presentations, and therapeutic considerations","volume":"60","author":"Kauvar DS","year":"2006","unstructured":"Kauvar DS, Lefering R, Wade CE. Impact of hemorrhage on trauma outcome: An overview of epidemiology, clinical presentations, and therapeutic considerations. J Trauma. 2006;60(6 Suppl):S3\u201311.","journal-title":"J Trauma"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.3109\/08941939.2014.941444"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsbiomaterials.9b01120"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtla.2019.100373"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1080\/08941939.2017.1423421"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jor.2018.11.006"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1039\/C5TB00250H"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2017.03.094"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2017.08.024"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2008.01.039"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1039\/C8BM00628H"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1089\/end.2008.0008"},{"key":"e_1_3_2_14_2","first-page":"273","article-title":"An in vivo comparison of the efficacy of hemostatic powders, using two porcine bleeding models","volume":"10","author":"MacDonald MH","year":"2017","unstructured":"MacDonald MH, Wang AY, Clymer JW, et al. An in vivo comparison of the efficacy of hemostatic powders, using two porcine bleeding models. Med Devices (Auckl). 2017;10:273\u2013279.","journal-title":"Med Devices (Auckl)"},{"issue":"3","key":"e_1_3_2_15_2","first-page":"302","article-title":"Evaluation of microporous polysaccharide hemospheres for parenchymal hemostasis during laparoscopic partial nephrectomy in the porcine model","volume":"10","author":"Murat FJ","year":"2006","unstructured":"Murat FJ, Le CQ, Ereth MH, et al. Evaluation of microporous polysaccharide hemospheres for parenchymal hemostasis during laparoscopic partial nephrectomy in the porcine model. JSLS. 2006;10(3):302\u2013306.","journal-title":"JSLS"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1080\/08941939.2020.1792007"},{"issue":"4","key":"e_1_3_2_17_2","first-page":"369","article-title":"Comparative safety and efficacy of topical hemostatic agents in a rat neurosurgical model","volume":"63","author":"Ereth MH","year":"2008","unstructured":"Ereth MH, Schaff M, Ericson EJ, et al. Comparative safety and efficacy of topical hemostatic agents in a rat neurosurgical model. Neurosurgery. 2008;63(4 Suppl 2):369\u201372; discussion 372.","journal-title":"Neurosurgery"},{"issue":"2","key":"e_1_3_2_18_2","article-title":"A prospective analysis of the effects of a powder-type hemostatic agent on the short-term outcomes after liver resection","volume":"60","author":"Kang MY, Cho JY, Han HS","year":"2024","unstructured":"Kang MY, Cho JY, Han HS, et al. A prospective analysis of the effects of a powder-type hemostatic agent on the short-term outcomes after liver resection. Medicina (Kaunas). 2024;60(2).","journal-title":"Medicina (Kaunas)"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.3390\/polym14183909"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1021\/acssuschemeng.8b05701"}],"container-title":["Clinical and Applied Thrombosis\/Hemostasis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10760296251405423","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/10760296251405423","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10760296251405423","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T14:05:33Z","timestamp":1777385133000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/10760296251405423"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":19,"alternative-id":["10.1177\/10760296251405423"],"URL":"https:\/\/doi.org\/10.1177\/10760296251405423","relation":{},"ISSN":["1076-0296","1938-2723"],"issn-type":[{"value":"1076-0296","type":"print"},{"value":"1938-2723","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"article-number":"10760296251405423"}}