{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T15:12:56Z","timestamp":1793459576348,"version":"4.5.0"},"reference-count":42,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Key R&D Program of the China Ministry of Science and Technology","award":["2024YFC2510600"],"award-info":[{"award-number":["2024YFC2510600"]}]},{"DOI":"10.13039\/501100014882","name":"Department of Finance of Hebei","doi-asserted-by":"publisher","award":["ZF2024086"],"award-info":[{"award-number":["ZF2024086"]}],"id":[{"id":"10.13039\/501100014882","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003787","name":"Natural Science Foundation of Hebei Province","doi-asserted-by":"publisher","award":["H2023206159"],"award-info":[{"award-number":["H2023206159"]}],"id":[{"id":"10.13039\/501100003787","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clin Appl Thromb Hemost"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Chronic hepatitis B virus (HBV) infection remains highly prevalent worldwide, particularly in China. However, its influence on the risk of venous thromboembolism (VTE) following orthopedic trauma has not been well characterized. This study aimed to investigate the incidence and risk factors of deep vein thrombosis (DVT) in HBV-infected patients after lower extremity fractures.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively reviewed the medical records of adult patients with chronic HBV infection who were hospitalized for lower extremity fractures at a tertiary trauma center between December 2013 and January 2024. Demographic, clinical, and laboratory data were collected. DVT was diagnosed using bilateral lower extremity Doppler ultrasonography. Univariate and multivariate logistic regression analyses were performed to identify independent risk factors. Receiver operating characteristic (ROC) curve analysis was used to determine optimal cutoff values for continuous predictors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 579 eligible patients, the overall incidence of post-fracture DVT was 30.4%. Independent risk factors identified in multivariate analysis included multiple fractures (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u2009.001, OR\u2009=\u20094.009, 95% CI:2.080 \u223c 7.725), a history of cerebral infarction (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u2009.009, OR\u2009=\u2009.753, 95% CI:1.287 \u223c 5.886), a history of cirrhosis (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u2009.001, OR\u2009=\u20095.211, 95% CI:3.273 \u223c 8.297),and elevated HBsAg levels (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u2009.001, OR\u2009=\u20091.002, 95% CI: 1.001 \u223c1.003). Higher hemoglobin levels (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u2009.001, OR\u2009=\u20090.979, 95% CI:0.970 \u223c 0.988) were independently associated with reduced DVT risk. In contrast, commonly used biomarkers such as D-dimer, fibrin degradation products (FDP), and liver function scores, including the Child\u2013Pugh score and the Model for End-Stage Liver Disease (MELD) score, were not significant predictors in multivariate analysis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>DVT is a common complication after lower extremity fractures in patients with chronic HBV infection. Multiple fractures, elevated HBsAg levels, prior stroke, and cirrhosis were independently associated with a higher risk of DVT, whereas higher hemoglobin levels were associated with a lower risk. These findings suggest that individualized thromboprophylaxis strategies may be considered in HBV-infected trauma patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10760296251415188","type":"journal-article","created":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T19:23:11Z","timestamp":1769023391000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Study on Deep Vein Thrombosis Incidence and Risk Factors in Orthopedic Trauma Patients with Chronic Hepatitis B: 579 Cases Analyzed"],"prefix":"10.1177","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-1443-2483","authenticated-orcid":false,"given":"Erdong","family":"Zhang","sequence":"first","affiliation":[{"name":"Hebei Medical University Third Affiliated Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-1511-299X","authenticated-orcid":false,"given":"Qianye","family":"Li","sequence":"additional","affiliation":[{"name":"Hebei Medical University Third Affiliated Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaqi","family":"Zhang","sequence":"additional","affiliation":[{"name":"The Third Hospital of Hebei Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haopei","family":"Li","sequence":"additional","affiliation":[{"name":"the Second Hospital of Hebei Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haofei","family":"Wang","sequence":"additional","affiliation":[{"name":"Hebei Medical University Third Affiliated Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenxiao","family":"Li","sequence":"additional","affiliation":[{"name":"Hebei Medical University Third Affiliated Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Jin","sequence":"additional","affiliation":[{"name":"Hebei Medical University Third Affiliated Hospital"},{"name":"Department of Orthopaedic Surgery, The Third Hospital of Hebei Medical University, Shijiazhuang, Hebei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5838-4025","authenticated-orcid":false,"given":"Zhiyong","family":"Hou","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, The Third Hospital of Hebei Medical University, Shijiazhuang, Hebei, China"},{"name":"Engineering Research Center of Orthopedic Minimally Invasive Intelligent Equipment, China Ministry of Education, Shijiazhuang, Hebei, China"},{"name":"Key Laboratory of Biomechanics of Hebei Province, Third Hospital of Hebei Medical University, Shijiazhuang, Hebei, China"},{"name":"NHC Key Laboratory of Intelligent Orthopaedic Equipment, Hebei Medical University Third Affiliated Hospital, Shijiazhuang, Hebei, China"},{"name":"Key Laboratory of Precise Assessment, Diagnosis, and Treatment of Soft Tissue Injury of Hebei Province, The Third Hospital of Hebei Medical University, Shijiazhuang, Hebei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,1,21]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1177\/10760296231165053"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1186\/s10195-023-00699-2"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005131-199605000-00002"},{"issue":"4","key":"e_1_3_4_5_2","doi-asserted-by":"crossref","DOI":"10.1016\/j.amepre.2010.01.010","article-title":"Surveillance for deep vein thrombosis and pulmonary embolism: Recommendations from a national workshop","volume":"38","author":"Raskob GE","year":"2010","unstructured":"Raskob GE, Silverstein R, Bratzler DW, Heit JA, White RH. Surveillance for deep vein thrombosis and pulmonary embolism: Recommendations from a national workshop. Am J Prev Med. 2010;38(4 Suppl):S502\u2013S509.","journal-title":"Am J Prev Med"},{"issue":"23","key":"e_1_3_4_6_2","article-title":"The epidemiology of venous thromboembolism","volume":"107","author":"White RH","year":"2003","unstructured":"White RH. The epidemiology of venous thromboembolism. Circulation. 2003;107(23 Suppl 1):I4\u2013I8.","journal-title":"Circulation"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-10-0992"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000038439"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.2147\/CIA.S161191"},{"issue":"4","key":"e_1_3_4_10_2","first-page":"234","article-title":"Thrombosis associated with viral hepatitis","volume":"2","author":"Galli L","year":"2014","unstructured":"Galli L, Gerdes VE, Guasti L, Squizzato A. Thrombosis associated with viral hepatitis. 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