{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T16:16:29Z","timestamp":1777479389282,"version":"3.51.4"},"reference-count":33,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Suzhou Industrial Park Medical and Health Innovation Research Project","award":["CXYJ2024A08"],"award-info":[{"award-number":["CXYJ2024A08"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clin Appl Thromb Hemost"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate the association between alactic base excess (ABE) and mortality outcomes in patients with sepsis-associated disseminated intravascular coagulation (DIC) within intensive care unit (ICU).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients with sepsis-associated DIC were identified using Sepsis-3 criteria and the Japanese Association for Acute Medicine 2 DIC criteria. Multivariable Cox models and restricted cubic splines (RCS) were used to assess the relationship between ABE and 30-day and 90-day ICU mortality, with inflection points derived from a recursive algorithm. The predictive value of adding ABE to the Sequential Organ Failure Assessment (SOFA) score was further compared with SOFA alone.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 4839 patients with sepsis-associated DIC were included (median age 67.2 years; 59.8% male). Compared with Q3, multivariable Cox models showed higher 30-day mortality in Q1 (HR\u2009=\u20091.44, 95% CI 1.16-1.79), Q2 (HR\u2009=\u20091.26, 95% CI 1.01-1.57), and Q4 (HR\u2009=\u20091.45, 95% CI 1.15-1.81), with similar patterns for 90-day mortality (Q1: HR\u2009=\u20091.38, 95% CI 1.13-1.68; Q2: HR\u2009=\u20091.28, 95% CI 1.04-1.56; Q4: HR\u2009=\u20091.45, 95% CI 1.18-1.77). RCS analysis demonstrated a U-shaped association between ABE and mortality, with risk increasing at both low and high ABE levels. Adding ABE to SOFA significantly improved prediction for 30-day and 90-day mortality, with notable reclassification gains.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>A clear U-shaped association was observed between ABE and 30-day\/90-day ICU mortality in the patients with sepsis-associated DIC, suggesting that deviations from mid-range values may reflect early metabolic deterioration. However, the clinical implications require cautious interpretation and further validation in larger or prospective cohorts.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10760296251415379","type":"journal-article","created":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T18:33:57Z","timestamp":1768329237000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Prognostic Impact of Alactic Base Excess in Critically Ill Patients with Sepsis-Associated Disseminated Intravascular Coagulation: A Retrospective Observational Study"],"prefix":"10.1177","volume":"32","author":[{"given":"Shu","family":"Zhang","sequence":"first","affiliation":[{"name":"Fourth Affiliated Hospital of Soochow University, Suzhou Dushu Lake 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