{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T11:07:24Z","timestamp":1779188844090,"version":"3.51.4"},"reference-count":29,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Changzhou Sci & Tech Program.","award":["No. CJ20245022."],"award-info":[{"award-number":["No. CJ20245022."]}]},{"name":"Technology Project of Changzhou Municipal Health Commission","award":["QN202222"],"award-info":[{"award-number":["QN202222"]}]},{"name":"Technology Project of Changzhou Municipal Health Commission","award":["QN202228"],"award-info":[{"award-number":["QN202228"]}]},{"name":"Science and Technology Projects of Changzhou City","award":["CJ20220249"],"award-info":[{"award-number":["CJ20220249"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clin Appl Thromb Hemost"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Thrombocytopenia is the most frequent hemostatic abnormality in sepsis and is closely linked to excess mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We undertook a retrospective cohort study of 82 septic patients admitted to Changzhou Second People's Hospital between 1 January 2023 and 30 June 2024. Participants were stratified by 28-day survival status. The clinical differences, platelet trends, prognostic value, and risk-factor analysis were analyzed between the two groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Survivors and non-survivors differed significantly in age, oxygenation index, white-blood-cell count, serum albumin, cholinesterase and in the prevalence of diabetes and hypertension (all comparisons\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u2009.05). Platelet counts measured on intensive care unit (ICU) days 1, 3, 7 and 14 were assessed for their prognostic value. By day 14, platelet counts were markedly higher in survivors than in non-survivors (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u2009.05). The day-14 platelet count yielded an area under the receiver-operating-characteristic (ROC) curve (AUC) of 0.640, outperforming the day-1 platelet count (AUC 0.514), APACHE II score (AUC 0.488) and Sequential Organ Failure Assessment (SOFA) score (AUC 0.394; all comparisons\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u2009.05). Kaplan\u2013Meier analysis showed that patients whose day-14 platelet count was \u2265 224\u2009\u00d7\u200910\n                      <jats:sup>9<\/jats:sup>\n                      L\n                      <jats:sup>\u22121<\/jats:sup>\n                      had significantly better 28-day survival than those below this threshold (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u2009.05). Platelet count\u2009&lt;\u2009224\u2009\u00d7\u200910\n                      <jats:sup>9<\/jats:sup>\n                      L\n                      <jats:sup>\u2212<\/jats:sup>\n                      <jats:sup>1<\/jats:sup>\n                      in day 14 was an independent predictor of 28-day mortality (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u2009.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The survival group shares high platelet count and maintaining platelet count at a higher level is associated with improving the 28-day prognosis of sepsis patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10760296261422759","type":"journal-article","created":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T19:18:41Z","timestamp":1773256721000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Dynamic 14-day Platelet Count Predicts 28-day Mortality in Sepsis: A Single-Center Retrospective Cohort Study"],"prefix":"10.1177","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-2783-6645","authenticated-orcid":false,"given":"Rui","family":"Zhang","sequence":"first","affiliation":[{"name":"Affiliated Changzhou Second Hospital of Nanjing Medical University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fanfeng","family":"Kong","sequence":"additional","affiliation":[{"name":"Affiliated Changzhou Second Hospital of Nanjing Medical 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Nanjing Medical 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