{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T18:16:54Z","timestamp":1792001814620,"version":"4.4.0"},"reference-count":59,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clin Appl Thromb Hemost"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>A large national database was conducted to examine in-hospital pressure ulcer(PU) development in patients who underwent peripheral thrombolysis and identify potential risk factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Source<\/jats:title>\n                    <jats:p>A cohort of 120\u2005744 adult patients from 2010 to 2019 was included in this study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective analysis employed univariate and multivariate logistic regression analyses to examine the relationship between patient\/hospital characteristics and the occurrence of PU in individuals who underwent peripheral thrombolysis. Patient factors considered included age, sex, race, comorbidities and complications, while hospital-level factors encompassed length of stay, cost, insurance type, bed size, admission type, hospital type, geographic location, and in-hospital mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Overall, 2.30% of patients developed PU. The rate of PU development varied annually between 2010 and 2019. Patients with PU were more likely to be non-elective admissions, hospitalized in northeastern regions, and insured by government programs rather than private insurance. PU development following peripheral vascular thrombolysis was linked to increased complications, higher healthcare costs, prolonged hospital stays, and elevated mortality rates. Patients with multiple comorbidities (three or more), chronic kidney disease, heart failure, anemia, weight loss, electrolyte imbalances, peripheral vascular disease, neurological disorders, and paraplegia were found to raise the risk of PU development. In addition, PU were associated with wound infection, wound dehiscence, pneumonia, urinary tract infection,bacteremia,cellulitis complications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our study unveiled the risk factors associated with the formation of in-hospital PU in patients receiving peripheral vascular thrombolysis therapy, in order to provide targeted prevention and improve management effectiveness.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10760296261427168","type":"journal-article","created":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T12:02:13Z","timestamp":1773230533000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["The Incidence and Risk Factors Associated with In-Hospital Pressure Ulcer Development After Peripheral Vascular Thrombolysis 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