{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T16:17:07Z","timestamp":1777479427210,"version":"3.51.4"},"reference-count":18,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clin Appl Thromb Hemost"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Lupus anticoagulant (LA) prolongs phospholipid-dependent coagulation tests and can falsely reduce intrinsic coagulation factor activities in one-stage assays. The quantitative relationship between LA intensity and the degree of assay interference remains insufficiently defined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>One hundred patients with LA-positive antiphospholipid syndrome or systemic lupus erythematosus were studied. FVIII:C, FIX:C, and FXI:C were measured using one-stage assays, and a modified assay incorporating SCT-confirm reagent was applied to reduce LA interference. The pseudo-lowering degree (PLD) was calculated to quantify correction efficacy. Associations between LA characteristics and reduced factor activities were analyzed, and activity levels or PLD values across LA-intensity subgroups were compared.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Using one-stage assays, reduced FVIII:C, FIX:C, and FXI:C were noted in 27%, 23%, and 26% of patients, respectively. LA intensity was unrelated to reduced FVIII:C but significantly associated with decreased FIX:C (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u2009.006) and FXI:C (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u2009.001). Moderate LA positivity showed higher FIX:C levels than weak positivity, whereas markedly lower FXI:C was seen only in strongly LA-positive patients. The SCT correction assay restored FVIII:C, FIX:C, and FXI:C to normal levels in approximately 66.7%, 82.6%, and 92.3% of affected cases, respectively. In strongly LA-positive patients, PLD values of FVIII:C, FIX:C, and FXI:C were significantly higher than in weak or moderate subgroups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>FVIII:C, FIX:C, and FXI:C exhibit differential susceptibility to LA interference. The SCT-based correction approach effectively mitigates this effect, especially for FXI and offers a practical improvement over conventional one-stage assays to avoid misclassification of intrinsic factor deficiencies in LA-positive patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10760296261427177","type":"journal-article","created":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T16:27:22Z","timestamp":1771950442000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Quantifying Lupus Anticoagulant Interference in Intrinsic Coagulation Factor Activity Assays and Evaluating the Corrective Performance of the SCT-Based Method"],"prefix":"10.1177","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-8337-5079","authenticated-orcid":false,"given":"Yu","family":"Yang","sequence":"first","affiliation":[{"name":"Peking University First Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuanyuan","family":"Li","sequence":"additional","affiliation":[{"name":"Peking University First Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Jiang","sequence":"additional","affiliation":[{"name":"Peking University First Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yao","family":"Lu","sequence":"additional","affiliation":[{"name":"Peking University First Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ran","family":"You","sequence":"additional","affiliation":[{"name":"Peking University First Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2935-3902","authenticated-orcid":false,"given":"Linzi","family":"Miao","sequence":"additional","affiliation":[{"name":"Peking University First Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Run","family":"Qin","sequence":"additional","affiliation":[{"name":"Peking University First Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zijing","family":"Zhu","sequence":"additional","affiliation":[{"name":"Peking University First Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Xing","sequence":"additional","affiliation":[{"name":"Peking University First Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chenxue","family":"Qu","sequence":"additional","affiliation":[{"name":"Peking University First 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