{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T19:58:35Z","timestamp":1793735915425,"version":"4.6.1"},"reference-count":45,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clin Appl Thromb Hemost"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Sepsis and its complications pose a major global health burden. Mendelian randomization (MR) provides a genetic approach to assess causality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a two-sample Mendelian randomization (MR) study using data from large-scale genome-wide association studies (GWAS). This study aimed to assess the causal effects of six key biomarkers (D-dimer, Galectin-3, activated protein C, tumor necrosis factor receptor 2, interleukin-6 receptor subunit alpha, and thrombomodulin) on six sepsis-related complications, including acute respiratory distress syndrome (ARDS) and acute renal failure. The primary analysis utilized the inverse-variance weighted (IVW) method, with comprehensive sensitivity analyses to assess for heterogeneity and pleiotropy. A False Discovery Rate (FDR) was applied to correct for multiple testing.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The primary IVW analysis suggested several potential causal associations. Genetically predicted D-dimer was associated with a lower risk of ARDS (OR\u2009=\u20090.63,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.025), IL-6R\u03b1 with a reduced risk of acute renal failure (OR\u2009=\u20090.85,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.035), and Galectin-3 with a lower risk of streptococcal septicaemia (OR\u2009=\u20090.95,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.039). Reverse MR analysis suggested that genetic liability to sepsis (critical care) was associated with lower D-dimer levels. However, after FDR correction, none of these associations remained statistically significant. Sensitivity analyses did not indicate the presence of significant horizontal pleiotropy.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study did not find robust genetic evidence to support a causal relationship between the six selected biomarkers and the risk of sepsis-related complications after correction for multiple testing. The suggestive associations observed prior to correction warrant further investigation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10760296261438237","type":"journal-article","created":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T14:14:36Z","timestamp":1778249676000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["The Causal Effects of Inflammation and Coagulation-Related Biomarkers on Sepsis-Related Complications: A Mendelian Randomization Study"],"prefix":"10.1177","volume":"32","author":[{"given":"Qi","family":"Yao","sequence":"first","affiliation":[{"name":"Critical Care Department, The Fourth People's Hospital, Guiyang, Guizhou Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-5828-7825","authenticated-orcid":false,"given":"Yiran","family":"Yao","sequence":"additional","affiliation":[{"name":"Affiliated Hospital of Guizhou Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhe","family":"Liao","sequence":"additional","affiliation":[{"name":"Critical Care Department, The Fourth People's Hospital, Guiyang, Guizhou Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Wang","sequence":"additional","affiliation":[{"name":"Critical Care Department, The Fourth People's Hospital, Guiyang, Guizhou Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengmeng","family":"Yu","sequence":"additional","affiliation":[{"name":"Critical Care Department, The Fourth People's Hospital, Guiyang, Guizhou Province, 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