{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T16:17:36Z","timestamp":1777479456871,"version":"3.51.4"},"reference-count":17,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100018916","name":"Suzhou Municipal Health Commission","doi-asserted-by":"crossref","award":["KJXW2022042"],"award-info":[{"award-number":["KJXW2022042"]}],"id":[{"id":"10.13039\/100018916","id-type":"DOI","asserted-by":"crossref"}]},{"name":"National Administration of Traditional Chinese Medicine","award":["XH40202-20250472-2"],"award-info":[{"award-number":["XH40202-20250472-2"]}]},{"name":"Youth Science and Technology Project","award":["KJXW2023046"],"award-info":[{"award-number":["KJXW2023046"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clin Appl Thromb Hemost"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Lower limb fractures with peripheral deep venous thrombosis (DVT) are common, yet unified stratified treatment standards are lacking. Quantifying thrombus burden guides decisions like inferior vena cava (IVC) filter implantation or anticoagulation. Existing scoring systems rarely integrate peripheral vein anatomy and imaging features, limiting clinical utility.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To develop a dual-dimensional scoring scale for thrombus burden quantification and validate its value in guiding stratified treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective study of 68 fracture-related DVT patients (Suzhou TCM Hospital, Nov 2022-Nov 2023) was conducted. A 0-25 point scale integrating 7 peripheral veins and muscular venous plexus features was designed. Receiver operating characteristic (ROC) analysis identified the optimal IVC filter cutoff; patients were split into filter group (\u22654 points, n\u2009=\u200921, filter\u2009+\u2009anticoagulation) and anticoagulation group (&lt;4 points, n\u2009=\u200947, single anticoagulation). 1:2 PSM eliminated baseline confounding; adverse events, scores and coagulation indices were compared.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      No adverse events or filter-related complications occurred. Both groups had significant post-treatment score and D-dimer reductions (all\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u2009.05). ROC confirmed 4 points as optimal cutoff (AUC\u2009=\u20090.923). The filter group had lower hemoglobin and higher D-dimer (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u2009.05), with no PT\/APTT differences. All filter group patients had residual thrombi, cord-like residuals in those with pre-treatment scores &gt;5 points.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This scale effectively quantifies thrombus burden, aids stratified DVT treatment, and provides a reliable basis for preoperative IVC filter implantation in orthopedic patients, with key clinical value.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10760296261442050","type":"journal-article","created":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T13:44:38Z","timestamp":1775655878000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Application of Novel Thrombosis Scale in Fracture Related Lower Extremity Deep Venous Thrombosis"],"prefix":"10.1177","volume":"32","author":[{"given":"Zhi-Chang","family":"Pan","sequence":"first","affiliation":[{"name":"Department of Vascular Surgery, Suzhou TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Suzhou, Jiangsu Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tian-Yi","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, Suzhou TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Suzhou, Jiangsu Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, Suzhou TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Suzhou, Jiangsu Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guang-Feng","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, Suzhou TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Suzhou, Jiangsu Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, Suzhou TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Suzhou, Jiangsu Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shu-Ming","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, Suzhou TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Suzhou, Jiangsu Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hua-Fa","family":"Que","sequence":"additional","affiliation":[{"name":"Department of Traditional Chinese Surgery, Longhua Hospital Shanghai University of Traditional Chinese Medicine, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1201-8916","authenticated-orcid":false,"given":"Jian-Jie","family":"Rong","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, Suzhou TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Suzhou, Jiangsu Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2026,4,8]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.7326\/AITC202209200"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.avsg.2014.11.025"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)30514-1"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1186\/s10195-023-00699-2"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2022.944506"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11239-009-0309-3"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.2147\/PPA.S353128"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvsv.2023.08.007"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvn.2022.05.001"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.avsg.2019.10.082"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa023153"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(76)91709-8"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.3310\/hta19980"},{"issue":"2","key":"e_1_3_3_15_2","first-page":"145","article-title":"Endovascular intervention in acute deep vein thrombosis","volume":"61","author":"Virk JS","year":"2013","unstructured":"Virk JS, Lookstein RA. Endovascular intervention in acute deep vein thrombosis. Minerva Cardioangiol. 2013;61(2):145\u2010154.","journal-title":"Minerva Cardioangiol"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcla.70019"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1055\/a-2505-8711"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1177\/00368504251364934"}],"container-title":["Clinical and Applied Thrombosis\/Hemostasis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10760296261442050","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/10760296261442050","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10760296261442050","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T14:05:45Z","timestamp":1777385145000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/10760296261442050"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":17,"alternative-id":["10.1177\/10760296261442050"],"URL":"https:\/\/doi.org\/10.1177\/10760296261442050","relation":{},"ISSN":["1076-0296","1938-2723"],"issn-type":[{"value":"1076-0296","type":"print"},{"value":"1938-2723","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"article-number":"10760296261442050"}}