{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T16:17:55Z","timestamp":1791908275818,"version":"4.3.4"},"reference-count":43,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clin Appl Thromb Hemost"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The incidence of thromboembolism (TE) is lower in prostate cancer than in other malignancies, but its sequelae are associated with increased mortality. This study investigated the incidence, risk factors, and survival impact of TE in Asian population with localized prostate cancer undergoing surgical management.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was a single-center retrospective cohort study of 4,880 localized prostate cancer patients who underwent surgical resection between March 1, 2002, and December 31, 2019. TE, venous thromboembolism (VTE), survival outcome, and related clinical variables were analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The 3-month TE cumulative incidence was 0.33% and the 3-month VTE incidence was 0.16%. The 2-year TE and VTE incidence were 0.81% and 0.29%, respectively. Older age (\u226575) (Subdistribution Hazard Ratio (SHR) 2.16, P = 0.0155) and an elevated C-reactive protein levels (\u22650.35 mg\/dL) (SHR 2.91, P = 0.0001) were significant risk factors for an increased incidence of TE. Older age (SHR 3.67, P = 0.0113) and pathological venous invasion (SHR 5.13, P = 0.0195) were significant risk factors for an increased incidence of VTE. The occurrence of VTE, older age, a history of diabetes, and high Gleason scores (\u22658) were independently associated with poor survival.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The incidence of TE was low in this East Asian cohort of surgically treated patients with localized prostate cancer, however, VTE was an independent predictor of worse overall survival. These findings suggest that pharmacological thromboprophylaxis should be reserved for patients identified as being at high-risk for TE, whereas mechanical measures appear sufficient for the general low-risk cohort.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10760296261452901","type":"journal-article","created":{"date-parts":[[2026,5,23]],"date-time":"2026-05-23T13:36:46Z","timestamp":1779543406000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Thromboembolic Events after Surgery for Localized Prostate Cancer: Incidence, Risk Factors, and Survival Outcomes"],"prefix":"10.1177","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6186-8095","authenticated-orcid":false,"given":"Yongho","family":"Noh","sequence":"first","affiliation":[{"name":"Chung-Ang University Hospital"},{"name":"Seoul National University College of Medicine"},{"name":"Seoul National University Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyunkyung","family":"Park","sequence":"additional","affiliation":[{"name":"Asan Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong-Yeop","family":"Shin","sequence":"additional","affiliation":[{"name":"Seoul National University College of Medicine"},{"name":"Seoul National University Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junshik","family":"Hong","sequence":"additional","affiliation":[{"name":"Seoul National University College of Medicine"},{"name":"Seoul National University Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyunsoo","family":"Cho","sequence":"additional","affiliation":[{"name":"Seoul National University College of Medicine"},{"name":"Seoul National University Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ja Min","family":"Byun","sequence":"additional","affiliation":[{"name":"Seoul National University College of Medicine"},{"name":"Seoul National University Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youngil","family":"Koh","sequence":"additional","affiliation":[{"name":"Seoul National University College of Medicine"},{"name":"Seoul National University Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung-Hwan","family":"Jeong","sequence":"additional","affiliation":[{"name":"Seoul National University College of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyeongdong","family":"Yuk","sequence":"additional","affiliation":[{"name":"Seoul National University College of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung\u2010Yong","family":"Cho","sequence":"additional","affiliation":[{"name":"Seoul National University College of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang Wook","family":"Jeong","sequence":"additional","affiliation":[{"name":"Seoul National University College of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ja Hyeon","family":"Ku","sequence":"additional","affiliation":[{"name":"Seoul National University College of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheol","family":"Kwak","sequence":"additional","affiliation":[{"name":"Seoul National University College of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inho","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Seoul National University Hospital, Biomedical Research Institute, Cancer Research Institute, Seoul National University College of Medicine, Seoul, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,5,23]]},"reference":[{"key":"e_1_3_7_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.160.6.809"},{"key":"e_1_3_7_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/nejm200012213432504"},{"key":"e_1_3_7_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2018.01.028"},{"key":"e_1_3_7_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa012385"},{"key":"e_1_3_7_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.3437"},{"key":"e_1_3_7_7_2","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2020003442"},{"key":"e_1_3_7_8_2","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13122905"},{"key":"e_1_3_7_9_2","article-title":"NCCN Clinical Practice Guidelines in Oncology: Cancer-Associated Venous Thromboembolic Disease, Version 3.2025","author":"Network NCC","unstructured":"Network NCC. NCCN Clinical Practice Guidelines in Oncology: Cancer-Associated Venous Thromboembolic Disease, Version 3.2025. National Comprehensive Cancer Network. https:\/\/www.nccn.org\/guidelines\/category_3. Accessed 8 January 2026.","journal-title":"National Comprehensive Cancer Network"},{"key":"e_1_3_7_10_2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21834"},{"key":"e_1_3_7_11_2","doi-asserted-by":"publisher","DOI":"10.7326\/m16-2586"},{"key":"e_1_3_7_12_2","volume-title":"Thromboembolic incidents in prostate cancer patients: A nationwide propensity-matched study","author":"Devarkonda V","year":"2024","unstructured":"Devarkonda V, Ali S, Kumar M, et al. Thromboembolic incidents in prostate cancer patients: A nationwide propensity-matched study. American Society of Clinical Oncology; 2024."},{"key":"e_1_3_7_13_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-04-460121"},{"key":"e_1_3_7_14_2","doi-asserted-by":"publisher","DOI":"10.1160\/TH04-08-0506"},{"key":"e_1_3_7_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0049-3848(09)70136-7"},{"key":"e_1_3_7_16_2","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2021005590"},{"key":"e_1_3_7_17_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-10-116327"},{"key":"e_1_3_7_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-9473(02)00225-6"},{"key":"e_1_3_7_19_2","doi-asserted-by":"publisher","DOI":"10.2307\/2670170"},{"key":"e_1_3_7_20_2","doi-asserted-by":"publisher","DOI":"10.22364\/bjmc.2022.10.2.06"},{"key":"e_1_3_7_21_2","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12123979"},{"key":"e_1_3_7_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2017.03.008"},{"key":"e_1_3_7_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.gim.2025.101466"},{"key":"e_1_3_7_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2022.12.014"},{"key":"e_1_3_7_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lanepe.2023.100739"},{"key":"e_1_3_7_26_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0094048"},{"key":"e_1_3_7_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2014.08.091"},{"key":"e_1_3_7_28_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12959-023-00526-y"},{"key":"e_1_3_7_29_2","article-title":"C-Reactive Protein, Genetic Susceptibility, and the Long-Term Risk of Venous Thromboembolism in Patients with Past Cancer","author":"Guan Y","year":"2024","unstructured":"Guan Y, Gan Z, Li S, et al. C-Reactive Protein, Genetic Susceptibility, and the Long-Term Risk of Venous Thromboembolism in Patients with Past Cancer. Thrombosis and Haemostasis. 2024.","journal-title":"Thrombosis and Haemostasis"},{"issue":"6","key":"e_1_3_7_30_2","first-page":"965","article-title":"Early change in C-reactive protein and venous thromboembolism in patients treated with immune checkpoint inhibitors","volume":"6","author":"Moik F","year":"2024","unstructured":"Moik F, Riedl JM, Barth D, et al. Early change in C-reactive protein and venous thromboembolism in patients treated with immune checkpoint inhibitors. Cardio Oncology. 2024;6(6):965-975.","journal-title":"Cardio Oncology"},{"key":"e_1_3_7_31_2","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdj068"},{"key":"e_1_3_7_32_2","doi-asserted-by":"publisher","DOI":"10.4330\/wjc.v2.i11.365"},{"key":"e_1_3_7_33_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.83.12.4533"},{"key":"e_1_3_7_34_2","doi-asserted-by":"publisher","DOI":"10.1177\/1076029620954282"},{"key":"e_1_3_7_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2005.04.011"},{"key":"e_1_3_7_36_2","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2022.11679"},{"key":"e_1_3_7_37_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.29535"},{"key":"e_1_3_7_38_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12185-024-03735-x"},{"key":"e_1_3_7_39_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.002702"},{"key":"e_1_3_7_40_2","doi-asserted-by":"publisher","DOI":"10.3390\/biom12020259"},{"key":"e_1_3_7_41_2","doi-asserted-by":"publisher","DOI":"10.1111\/jth.13002"},{"key":"e_1_3_7_42_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-019-02705-x"},{"key":"e_1_3_7_43_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11845-021-02730-z"},{"key":"e_1_3_7_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijmedinf.2022.104733"}],"container-title":["Clinical and Applied Thrombosis\/Hemostasis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10760296261452901","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/10760296261452901","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10760296261452901","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T07:20:26Z","timestamp":1779780026000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/10760296261452901"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":43,"alternative-id":["10.1177\/10760296261452901"],"URL":"https:\/\/doi.org\/10.1177\/10760296261452901","relation":{},"ISSN":["1076-0296","1938-2723"],"issn-type":[{"value":"1076-0296","type":"print"},{"value":"1938-2723","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"article-number":"10760296261452901"}}