{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T13:35:49Z","timestamp":1786541749364,"version":"build-2736575974"},"reference-count":32,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100005762","name":"National Taiwan University Hospital","doi-asserted-by":"publisher","award":["NTUH (113-N0030)"],"award-info":[{"award-number":["NTUH (113-N0030)"]}],"id":[{"id":"10.13039\/501100005762","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clin Appl Thromb Hemost"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Influenza is a major respiratory pathogen worldwide, and bacterial co-infection substantially contributes to adverse outcomes. However, early recognition of co-infection in the emergency department remains challenging. The immature platelet fraction (IPF) has demonstrated diagnostic value in sepsis, whereas its role in viral infections and bacterial co-infection is unclear. This study aimed to evaluate whether IPF can serve as a marker for identifying influenza patients with co-infection.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively identified adult patients presenting to the emergency department of National Taiwan University Hospital between May 2023 and December 2024 who underwent influenza testing and complete blood count with IPF measurement. Patients were categorized as influenza mono-infection, influenza with co-infection, or non-influenza. Laboratory parameters, including IPF and white blood cell (WBC) counts, were compared, and risk factors associated with co-infection among influenza patients were evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 365 patients were included, of whom 134 (36.7%) tested positive for influenza. IPF tended to be lower in influenza-positive than influenza-negative patients (5.7% vs. 6.1%, p = 0.054). Among influenza-positive patients, 41 (30.6%) had co-infection. IPF was higher in patients with co-infection than in those with influenza mono-infection (6.5% vs. 5.1%, p &lt; 0.05). The combined criterion of WBC \u2265 10\u00d710\n                      <jats:sup>9<\/jats:sup>\n                      \/L and IPF \u2265 6% was independently associated with co-infection (adjusted OR, 9.91; 95% confidence interval: 2.80\u201335.10; p &lt; 0.01).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Higher IPF is associated with co-infection among patients with influenza. When combined with WBC, IPF may serve as a useful marker for identifying co-infection at emergency department presentation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10760296261473008","type":"journal-article","created":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T11:35:01Z","timestamp":1786361701000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Immature Platelet Fraction as a Marker of Influenza-Associated Co-Infection in Emergency Department Patients"],"prefix":"10.1177","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1315-807X","authenticated-orcid":false,"given":"Jia-Arng","family":"Lee","sequence":"first","affiliation":[{"name":"National Taiwan University Hospital"},{"name":"National Taiwan University College of Medicine"},{"name":"National Taiwan University College of Medicine"},{"name":"Department of Family Medicine"},{"name":"National Taiwan University Hospital Hsin-Chu Branch"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-4677-8797","authenticated-orcid":false,"given":"Yi-Hua","family":"Wang","sequence":"additional","affiliation":[{"name":"National Taiwan University Hospital"},{"name":"National Taiwan University College of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Tseng","sequence":"additional","affiliation":[{"name":"National Taiwan University Hospital"},{"name":"National Taiwan University College of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming-Yan","family":"Yang","sequence":"additional","affiliation":[{"name":"National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan"},{"name":"Department of Neurology, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi-Han","family":"Wu","sequence":"additional","affiliation":[{"name":"National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao-Chieh","family":"Chiu","sequence":"additional","affiliation":[{"name":"National Taiwan University Hospital"},{"name":"National Taiwan University College of Medicine"},{"name":"National Taiwan University College of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,8,10]]},"reference":[{"key":"e_1_3_8_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwaa196"},{"key":"e_1_3_8_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)33293-2"},{"key":"e_1_3_8_4_2","doi-asserted-by":"publisher","DOI":"10.1017\/ice.2021.96"},{"key":"e_1_3_8_5_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid1408.071313"},{"key":"e_1_3_8_6_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-018-3548-0"},{"key":"e_1_3_8_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00298-15"},{"key":"e_1_3_8_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajem.2011.02.012"},{"key":"e_1_3_8_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.120.314645"},{"key":"e_1_3_8_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-012-2725-7"},{"key":"e_1_3_8_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep08019"},{"key":"e_1_3_8_12_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.11-2860"},{"key":"e_1_3_8_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2022.111447"},{"key":"e_1_3_8_14_2","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10040877"},{"key":"e_1_3_8_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11239-021-02560-x"},{"key":"e_1_3_8_16_2","doi-asserted-by":"publisher","DOI":"10.4103\/ijpm.ijpm_365_24"},{"key":"e_1_3_8_17_2","doi-asserted-by":"publisher","DOI":"10.1080\/20469047.2019.1697574"},{"key":"e_1_3_8_18_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0258936"},{"key":"e_1_3_8_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2021.07.048"},{"key":"e_1_3_8_20_2","volume-title":"Performance standards for antimicrobial susceptibility testing, 30th ed Approved standard, CLSI publication M100-S30","author":"CLSI","year":"2020","unstructured":"CLSI. 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