{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T13:30:53Z","timestamp":1787146253817,"version":"build-2736575974"},"reference-count":19,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Zhejiang Provincial Natural Science Foundation of China","award":["LQ22H010001"],"award-info":[{"award-number":["LQ22H010001"]}]},{"name":"Yangtze River Delta Health Research Fund of Zhejiang Province","award":["2023CSJ-3-A008"],"award-info":[{"award-number":["2023CSJ-3-A008"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clin Appl Thromb Hemost"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The relationship between onset timing of hospital-associated pulmonary embolism (HAPE) and mortality remains unclear. This study assessed the independent prognostic role of onset timing for 6-month all-cause mortality among HAPE patients, with adjustment for the pulmonary embolism severity index (PESI) and treatment regimens.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this retrospective cohort study, 140 HAPE patients were enrolled. According to onset time, patients were stratified into two groups: in-hospital onset (n = 94) and post-discharge onset (n = 46). Survival curves were plotted via the Kaplan-Meier (KM) methods, and intergroup differences were assessed using the log-rank test. Univariate and multivariate Cox regression were performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Overall, 6-month mortality was 27.1% (38\/140). Patients with post-discharge onset demonstrated a substantially higher mortality rate than those with in-hospital onset (39.1% vs. 21.3%,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.026; log-rank\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.03). In the univariate Cox model, age, post-discharge onset of HAPE, admitting departments, general anesthesia, pulse rate (PR) \u2265 110 beats per minute (bpm), systolic blood pressure (SBP) &lt; 100 mmHg, oxygen saturation (SpO\n                      <jats:sub>2<\/jats:sub>\n                      ) &lt; 90%, altered mental status, intermediate- or high-risk PE risk stratification and higher PESI score were identified as potential predictors of 6-month mortality (all\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.1). Multivariate Cox regression revealed post-discharge onset as an independent correlate of 6-month mortality (HR = 1.95, 95% CI: 1.01\u20133.76,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.046). Subgroup analyses confirmed the robustness of findings.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Post-discharge onset was identified as an independent risk factor for 6-month all-cause mortality in patients with HAPE. Venous thromboembolism (VTE) assessment before discharge should be emphasized.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10760296261479848","type":"journal-article","created":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:12:07Z","timestamp":1786975927000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["The Impact of Onset Timing on 6-Month All-Cause Mortality in Hospital-Associated Pulmonary Embolism: A Retrospective Cohort Study"],"prefix":"10.1177","volume":"32","author":[{"given":"Jie","family":"Yao","sequence":"first","affiliation":[{"name":"Affiliated Haining Hospital of Jiaxing University"},{"name":"Haining People\u2019s Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing xing","family":"Zhu","sequence":"additional","affiliation":[{"name":"Affiliated Haining Hospital of Jiaxing University"},{"name":"Haining People\u2019s Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi hao","family":"Liu","sequence":"additional","affiliation":[{"name":"Affiliated Haining Hospital of Jiaxing University"},{"name":"Haining People\u2019s Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya hong","family":"Sun","sequence":"additional","affiliation":[{"name":"Affiliated Haining Hospital of Jiaxing University"},{"name":"Haining People\u2019s Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li fei","family":"Huang","sequence":"additional","affiliation":[{"name":"Affiliated Haining Hospital of Jiaxing University"},{"name":"Haining People\u2019s Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-0122-3507","authenticated-orcid":false,"given":"Huan","family":"Xu","sequence":"additional","affiliation":[{"name":"Affiliated Haining Hospital of Jiaxing University"},{"name":"Haining People\u2019s Hospital"},{"name":"Zhouwangmiao Town Health Center"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,8,17]]},"reference":[{"key":"e_1_3_8_2_2","doi-asserted-by":"publisher","DOI":"10.1177\/02683555241231615"},{"key":"e_1_3_8_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.rpth.2023.100030"},{"key":"e_1_3_8_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2022.40373"},{"key":"e_1_3_8_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/jth.15736"},{"key":"e_1_3_8_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000769"},{"key":"e_1_3_8_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11239-024-03017-7"},{"key":"e_1_3_8_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2022.09.028"},{"key":"e_1_3_8_9_2","doi-asserted-by":"publisher","DOI":"10.3760\/cma.j.cn112147-20241218-00315"},{"key":"e_1_3_8_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehz405"},{"key":"e_1_3_8_11_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200506-8620C"},{"key":"e_1_3_8_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2005.01204.x"},{"key":"e_1_3_8_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2009.03678.x"},{"key":"e_1_3_8_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/0895-43569500510-2"},{"key":"e_1_3_8_15_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2023.1024567"},{"key":"e_1_3_8_16_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000001415"},{"key":"e_1_3_8_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lanwpc.2024.101258"},{"key":"e_1_3_8_18_2","doi-asserted-by":"crossref","first-page":"107602962412384","DOI":"10.1177\/10760296241253844","article-title":"Charlson and Elixhauser Comorbidity Indices for Prediction of Mortality and Hospital Readmission in Patients With Acute Pulmonary Embolism","volume":"30","author":"O\u2019Hara A","year":"2024","unstructured":"O\u2019Hara A, Pozin J, Abourahma M, et al. Charlson and Elixhauser Comorbidity Indices for Prediction of Mortality and Hospital Readmission in Patients With Acute Pulmonary Embolism. Clin Appl Thromb Hemost. 2024;30:10760296241238444.","journal-title":"Clin Appl Thromb Hemost"},{"key":"e_1_3_8_19_2","doi-asserted-by":"publisher","DOI":"10.12659\/MSM.943450"},{"key":"e_1_3_8_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2021.07.055"}],"container-title":["Clinical and Applied Thrombosis\/Hemostasis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10760296261479848","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/10760296261479848","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10760296261479848","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T13:16:44Z","timestamp":1787145404000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/10760296261479848"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":19,"alternative-id":["10.1177\/10760296261479848"],"URL":"https:\/\/doi.org\/10.1177\/10760296261479848","relation":{},"ISSN":["1076-0296","1938-2723"],"issn-type":[{"value":"1076-0296","type":"print"},{"value":"1938-2723","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"article-number":"10760296261479848"}}