{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T04:12:44Z","timestamp":1788667964858,"version":"build-2803163510"},"reference-count":34,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clin Appl Thromb Hemost"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study used two-sample Mendelian Randomization to investigate the causal link between multiple biological aging indicators and vascular disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Summary genetic data was obtained from genome-wide association studies (GWAS) focusing on aging-related exposures and various vascular disease outcomes. The exposures included granulocyte proportions, PAI-1 (plasminogen activator inhibitor-1), telomere lengths, and the Frailty Index. The primary analysis employed the Inverse Variance Weighted (IVW) method to estimate causal relationships, supported by MR-Egger, weighted median, and weighted mode methods. Sensitivity analyses, including Cochran\u2019s Q test, MR-Egger regression, leave-one-out test, and the MR Pleiotropy Residual Sum and Outlier (MR-PRESSO) test, were conducted to evaluate heterogeneity and pleiotropy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The analysis revealed distinct pathways after sensitivity adjustments. A higher genetically predicted Frailty Index was associated with an increased risk of abdominal aortic aneurysm (OR=2.5935, 95% CI: 1.3936\u20134.8268,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.0026, false discovery rate (FDR)=0.0475), atherosclerosis excluding cerebral and coronary sclerosis (OR=2.0262, 95% CI:1.5179\u20132.705,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =1.66\u00d710\n                      <jats:sup>-6<\/jats:sup>\n                      , FDR=1\u00d710\n                      <jats:sup>-4<\/jats:sup>\n                      ), and arterial thromboembolic events (OR = 4.0306, 95% CI: 1.7133\u20139.4818,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.0014, FDR = 0.0337). Conversely, longer telomere length demonstrated a strong, specific protective effect against abdominal aortic aneurysm (OR=0.5008, 95% CI:0.4111\u20130.6100,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =6.42\u00d710\n                      <jats:sup>-12<\/jats:sup>\n                      , FDR=9.25\u00d710\n                      <jats:sup>-10<\/jats:sup>\n                      ), indicating that shorter telomere length is associated with an increased risk of AAA. Furthermore, a lower granulocyte proportion was causally linked to an increased risk of thoracic aortic aneurysm (OR=0.0181, 95% CI: 0.0014\u20130.2376,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.0023, FDR=0.0465).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study identifies three genetic pathways linking biological aging to vascular disease, offering new molecular targets for its prevention and treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10760296261486120","type":"journal-article","created":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T10:32:46Z","timestamp":1788431566000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Investigation of the Causal Association Between Biological Aging Indicators and Vascular Disease Through Two-Sample Mendelian Randomization Analysis"],"prefix":"10.1177","volume":"32","author":[{"given":"Hao","family":"Yan","sequence":"first","affiliation":[{"name":"General Hospital of Northern Theater Command"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Shan","sequence":"additional","affiliation":[{"name":"General Hospital of Northern Theater Command"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Hui","sequence":"additional","affiliation":[{"name":"General Hospital of Northern Theater Command"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-8168-8428","authenticated-orcid":false,"given":"Qian","family":"Xia","sequence":"additional","affiliation":[{"name":"General Hospital of Northern Theater Command"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,9,3]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/CM9.0000000000002839"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-025-97481-7"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10522-021-09910-5"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2015.12.023"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2020.630186"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2025.102835"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacasi.2024.02.002"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.117.306458"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12175512"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms241411538"},{"key":"e_1_3_5_12_2","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a040501"},{"key":"e_1_3_5_13_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-021-02398-9"},{"key":"e_1_3_5_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-021-00944-6"},{"key":"e_1_3_5_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-022-03521-7"},{"key":"e_1_3_5_16_2","doi-asserted-by":"publisher","DOI":"10.3390\/biom14030343"},{"key":"e_1_3_5_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/lifemedi\/lnad033"},{"key":"e_1_3_5_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/eci.14056"},{"key":"e_1_3_5_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2024.e31198"},{"key":"e_1_3_5_20_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0304300"},{"key":"e_1_3_5_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2023.09.011"},{"key":"e_1_3_5_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.avsg.2023.09.097"},{"key":"e_1_3_5_23_2","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2024.1353908"},{"key":"e_1_3_5_24_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-025-02880-9"},{"key":"e_1_3_5_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jare.2024.06.012"},{"key":"e_1_3_5_26_2","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afaf075"},{"key":"e_1_3_5_27_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1438838"},{"key":"e_1_3_5_28_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41514-024-00154-4"},{"key":"e_1_3_5_29_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard-2024-225630"},{"key":"e_1_3_5_30_2","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-021-02123-z"},{"key":"e_1_3_5_31_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.123.319244"},{"key":"e_1_3_5_32_2","article-title":"Anatomy, Abdomen and Pelvis, Renal Veins. 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