{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T09:06:23Z","timestamp":1789203983567,"version":"build-2803163510"},"reference-count":26,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100020777","name":"Zhejiang Pharmaceutical Association","doi-asserted-by":"crossref","award":["2023ZYY06"],"award-info":[{"award-number":["2023ZYY06"]}],"id":[{"id":"10.13039\/501100020777","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clin Appl Thromb Hemost"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Patients with solid tumors are at increased risk of venous thromboembolism (VTE), and COVID-19 infection may further enhance thrombotic risk. Although prophylactic-dose thromboprophylaxis is recommended for hospitalized patients with COVID-19 when bleeding risk is acceptable, its clinical impact among patients with solid tumors remains uncertain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a multicenter retrospective cohort study across three tertiary hospitals in China from December 2022 to January 2023. Adult patients with solid tumors hospitalized for laboratory-confirmed COVID-19 were included. Patients receiving prophylactic-dose thromboprophylaxis within 24 hours of admission were classified as the early cohort, whereas those initiating prophylaxis after 24 hours or receiving no prophylaxis were classified as the non-early cohort. The primary outcome was 30-day mortality. Secondary outcomes included thrombotic events, bleeding events, and 60-day mortality. Multivariable Cox regression, inverse probability of treatment weighting (IPTW) analyses, multiple imputation, and sensitivity analyses were performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 431 patients, 86 were classified into the early cohort and 345 into the non-early cohort. Early prophylactic-dose thromboprophylaxis was not significantly associated with 30-day mortality (adjusted HR=1.468, 95% CI 0.840\u20132.567, P=0.173) or 60-day mortality (adjusted HR=1.386, 95% CI 0.798\u20132.408, P=0.241). IPTW-adjusted analyses and sensitivity analyses yielded consistent results. No significant associations were observed between early thromboprophylaxis and thrombotic or bleeding events.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In this multicenter cohort of patients with solid tumors hospitalized for COVID-19, early prophylactic-dose thromboprophylaxis was not clearly associated with improved 30-day or 60-day mortality. Further prospective studies are needed to identify patients who may benefit from optimized thromboprophylaxis strategies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10760296261488613","type":"journal-article","created":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T05:54:03Z","timestamp":1789019643000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Early Prophylactic-Dose Thromboprophylaxis and 30-Day Mortality in Solid Tumor Patients Hospitalized for COVID-19: A Multicenter Retrospective Cohort Study"],"prefix":"10.1177","volume":"32","author":[{"given":"Linlin","family":"Yang","sequence":"first","affiliation":[{"name":"The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Chen","sequence":"additional","affiliation":[{"name":"The Second Affiliated 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