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Understanding its pathophysiology may help identify plasma biomarkers that reflect disease severity and treatment response. This study compared plasma tissue factor (TF) concentrations between end-stage renal disease (ESRD) patients and healthy controls using combined 2022 and 2023 retrospective cohorts (142 ESRD, 22 controls). Mean TF levels were calculated, and percent change for each ESRD patient was determined relative to the healthy control mean. In 2022, normal human plasma (NHP) TF averaged 96.37 \u00b1 12.72 pg\/mL versus 305.19 \u00b1 11.57 pg\/mL in ESRD patients, a 216.68% increase. In 2023, NHP TF was 60.19 \u00b1 12.12 pg\/mL compared with 341.93 \u00b1 20.40 pg\/mL in ESRD patients, a 468.11% increase. Across both cohorts, ESRD patients showed markedly elevated TF levels, supporting a pronounced pro-thrombotic state driven by inflammation and endothelial dysfunction from chronic uremic metabolite accumulation.<\/jats:p>","DOI":"10.1177\/10760296261496960","type":"journal-article","created":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T18:27:16Z","timestamp":1791397636000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Interrelationship of Tissue Factor With Thromboinflammatory Biomarkers in ESRD and CKD 5 Patients"],"prefix":"10.1177","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-8657-0401","authenticated-orcid":false,"given":"Luke","family":"Rohde","sequence":"first","affiliation":[{"name":"Saint Louis University School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2219-7049","authenticated-orcid":false,"given":"Fakiha","family":"Siddiqui","sequence":"additional","affiliation":[{"name":"Department of Thrombosis and Hemostasis, Loyola Stritch School of Medicine, Maywood, IL, United States of America"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine","family":"Konczak","sequence":"additional","affiliation":[{"name":"Department of Thrombosis and Hemostasis, Loyola Stritch School of Medicine, Maywood, IL, United States of America"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ella","family":"Kaufmann","sequence":"additional","affiliation":[{"name":"Department of Thrombosis and Hemostasis, Loyola Stritch School of Medicine, Maywood, IL, United States of America"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9342-4213","authenticated-orcid":false,"given":"Debra","family":"Hoppensteadt","sequence":"additional","affiliation":[{"name":"Department of Thrombosis and Hemostasis, Loyola Stritch School of Medicine, Maywood, IL, United States of America"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1418-7369","authenticated-orcid":false,"given":"Jeanine","family":"Walenga","sequence":"additional","affiliation":[{"name":"Department of Thrombosis and Hemostasis, Loyola Stritch School of Medicine, Maywood, IL, United States of America"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinod","family":"Bansal","sequence":"additional","affiliation":[{"name":"Department of Thrombosis and Hemostasis, Loyola Stritch School of Medicine, Maywood, IL, United States of America"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamzah","family":"Hussain","sequence":"additional","affiliation":[{"name":"Department of Thrombosis and Hemostasis, Loyola Stritch School of Medicine, Maywood, IL, United States of America"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3465-2499","authenticated-orcid":false,"given":"Jawed","family":"Fareed","sequence":"additional","affiliation":[{"name":"Department of Thrombosis and Hemostasis, Loyola Stritch School of Medicine, Maywood, IL, United States of America"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kavitha","family":"Vellanki","sequence":"additional","affiliation":[{"name":"Department of Thrombosis and Hemostasis, Loyola Stritch School of Medicine, Maywood, IL, United States of America"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,10,7]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2214-109X(23)00570-3"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30045-3"},{"issue":"3","key":"e_1_3_4_4_2","first-page":"237","article-title":"Systemic inflammation in dialysis patients with end-stage renal disease: causes and consequences","volume":"56","author":"Yao Q","year":"2004","unstructured":"Yao Q, Axelsson J, Heimburger O, Stenvinkel P, Lindholm B. 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