{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T04:48:28Z","timestamp":1791953308793,"version":"4.3.4"},"reference-count":45,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clin Appl Thromb Hemost"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Evidence surrounding the optimal antithrombotic regimen for patients with chronic coronary syndrome (CCS) requiring oral anticoagulation remains scarce. This meta-analysis evaluates the efficacy and safety of oral anticoagulant (OAC) monotherapy compared to OAC plus single antiplatelet therapy (SAPT) in this population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We systematically searched for randomized controlled trials (RCTs) till February 2026 comparing OAC monotherapy versus OAC plus SAPT in patients with CCS. Primary outcomes included major or clinically relevant non-major bleeding, net adverse clinical events (NACE), all-cause mortality, and cardiovascular (CV) deaths. Pooled risk ratios (RR) with 95% confidence intervals (CIs) were calculated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      OAC monotherapy was associated with a significantly lower risk of major or clinically relevant non-major bleeding compared with dual antithrombotic therapy (DAT) (RR: 0.50; 95% CI: 0.38\u20130.65; p &lt; 0.001; I\n                      <jats:sup>2<\/jats:sup>\n                      = 42%). Similarly, OAC monotherapy significantly reduced the incidence of NACE (RR: 0.64; 95% CI: 0.50\u20130.81; p &lt; 0.001; I\n                      <jats:sup>2<\/jats:sup>\n                      = 64%). There was no significant difference between the two strategies in all-cause mortality (RR: 0.79; 95% CI: 0.55\u20131.13; p = 0.20; I\n                      <jats:sup>2<\/jats:sup>\n                      = 52%). However, OAC monotherapy was associated with a significantly lower risk of CV mortality (RR: 0.71; 95% CI: 0.53\u20130.97; p = 0.03; I\n                      <jats:sup>2<\/jats:sup>\n                      = 3%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In patients with CCS requiring long-term oral anticoagulation, OAC monotherapy significantly reduced major or clinically relevant non-major bleeding, CV mortality, and NACE compared with dual antithrombotic therapy (DAT). Rates of major ischemic events, Myocardial Infarction, stroke, and all-cause mortality were comparable between the two strategies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10760296261496972","type":"journal-article","created":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T11:00:35Z","timestamp":1791802835000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Oral Anticoagulant Monotherapy vs. Combination Therapy in Chronic Coronary Syndrome Requiring Long-Term Anticoagulation: An Updated Meta-Analysis of Randomized Controlled Trials"],"prefix":"10.1177","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-0518-4900","authenticated-orcid":false,"given":"Mahwish","family":"Sarwar","sequence":"first","affiliation":[{"name":"Dow University of Health Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaikh 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