{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T14:43:06Z","timestamp":1792248186138,"version":"4.4.0"},"reference-count":27,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"The Wuhan Municipal Health and Family Planning Commission Foundation","award":["WE15A03"],"award-info":[{"award-number":["WE15A03"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clin Appl Thromb Hemost"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The neutrophil-to-lymphocyte ratio (NLR) and atherogenic index of plasma (AIP) have been associated with coronary artery disease (CAD). We investigated their associations with angiographically confirmed CAD and lesion severity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective study included 2,933 patients undergoing coronary angiography for suspected CAD at Wuhan Third Hospital. CAD was defined as \u226550% luminal stenosis in at least one major coronary artery or branch. Lesion severity was assessed using the Gensini score. Multivariable logistic regression and receiver operating characteristic analyses were performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 2,933 patients, 1,615 had CAD and 1,318 had no significant stenosis. NLR and AIP were higher in patients with CAD and increased across Gensini score categories (all P&lt;0.05). After adjustment, AIP remained independently associated with CAD (OR=1.557, P=0.042), whereas NLR did not (OR=1.019, P=0.581). AIP alone showed limited discrimination (AUC=0.537). A multivariable model including age, blood pressure, fasting blood glucose, and AIP showed an AUC of 0.779. Adding AIP did not significantly improve AUC (DeLong P=0.153) or NRI (0.071, P=0.106), although IDI improvement was significant (0.002, P&lt;0.05).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In patients undergoing coronary angiography for suspected CAD, NLR and AIP were associated with CAD and angiographic disease burden. AIP remained independently associated with CAD, whereas NLR did not. However, AIP showed limited discrimination and no clear incremental improvement beyond conventional variables. These findings do not support population screening or routine clinical implementation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10760296261497036","type":"journal-article","created":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T20:41:17Z","timestamp":1792010477000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Association of Neutrophil-To-Lymphocyte Ratio and Atherogenic Index of Plasma With Angiographically Confirmed Coronary Artery Disease"],"prefix":"10.1177","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-8533-236X","authenticated-orcid":false,"given":"Xuexue","family":"Yang","sequence":"first","affiliation":[{"name":"Wuhan Third Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofang","family":"Xiong","sequence":"additional","affiliation":[{"name":"Wuhan Third Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongsheng","family":"Li","sequence":"additional","affiliation":[{"name":"Wuhan Third Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,10,14]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2014.04.015"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.3390\/jcm14051583"},{"key":"e_1_3_5_4_2","first-page":"ehag028","article-title":"The year in cardiovascular medicine 2025: the top 10 papers in ischaemic heart disease","author":"Gorog DA","year":"2026","unstructured":"Gorog DA, de Silva R, Boden WE. The year in cardiovascular medicine 2025: the top 10 papers in ischaemic heart disease. European Heart Journal. 2026:ehag028.","journal-title":"European Heart Journal"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2025.1514585"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature10146"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2025.1517507"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23073636"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.1586\/erc.12.159"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.1586\/14779072.2016.1154788"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0108183"},{"key":"e_1_3_5_12_2","doi-asserted-by":"publisher","DOI":"10.1177\/0003319715577529"},{"key":"e_1_3_5_13_2","first-page":"240","article-title":"Atherogenic Index of Plasma (AIP): A marker of cardiovascular disease","volume":"29","author":"Niroumand S","year":"2015","unstructured":"Niroumand S, Khajedaluee M, Khadem-Rezaiyan M, et al. Atherogenic Index of Plasma (AIP): A marker of cardiovascular disease. Medical journal of the Islamic Republic of Iran. 2015;29:240.","journal-title":"Medical journal of the Islamic Republic of Iran"},{"issue":"3","key":"e_1_3_5_14_2","first-page":"e00361","article-title":"Effectiveness of plasma atherogenic index as a predictor of cardiovascular risk in patients with metabolic syndrome and related cardiometabolic conditions: a systematic review","volume":"15","author":"Shaybah ME","year":"2026","unstructured":"Shaybah ME, Alenezi GT, Alqahtani MM, et al. Effectiveness of plasma atherogenic index as a predictor of cardiovascular risk in patients with metabolic syndrome and related cardiometabolic conditions: a systematic review. Cardiovascular Endocrinology & Metabolism. 2026;15(3):e00361.","journal-title":"Cardiovascular Endocrinology & Metabolism"},{"key":"e_1_3_5_15_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-025-02593-z"},{"key":"e_1_3_5_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-89307-z"},{"issue":"2","key":"e_1_3_5_17_2","first-page":"55","article-title":"Analyzing Gensini score as a semi-continuous outcome","volume":"11","author":"Kashani H","year":"2016","unstructured":"Kashani H, Zeraati H, Mohammad K, et al. Analyzing Gensini score as a semi-continuous outcome. The Journal of Tehran University Heart Center. 2016;11(2):55-61.","journal-title":"The Journal of Tehran University Heart Center"},{"key":"e_1_3_5_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(83)80105-2"},{"key":"e_1_3_5_19_2","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2004.033175"},{"key":"e_1_3_5_20_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehaa1034"},{"key":"e_1_3_5_21_2","doi-asserted-by":"publisher","DOI":"10.1536\/ihj.14-175"},{"key":"e_1_3_5_22_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehz425"},{"key":"e_1_3_5_23_2","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.P011668"},{"key":"e_1_3_5_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-9120(01)00263-6"},{"key":"e_1_3_5_25_2","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2009.137489"},{"key":"e_1_3_5_26_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2021.804214"},{"key":"e_1_3_5_27_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2018.00396"},{"issue":"1","key":"e_1_3_5_28_2","first-page":"1765835","article-title":"Atherogenic index in type 2 diabetes and its relationship with chronic microvascular complications","volume":"2018","author":"Li Z","year":"2018","unstructured":"Li Z, Huang Q, Sun L, Bao T, Dai Z. Atherogenic index in type 2 diabetes and its relationship with chronic microvascular complications. 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