{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T16:20:33Z","timestamp":1777479633035,"version":"3.51.4"},"reference-count":20,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[1999,4,1]],"date-time":"1999-04-01T00:00:00Z","timestamp":922924800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Appl Thromb Hemost"],"published-print":{"date-parts":[[1999,4]]},"abstract":"<jats:p>\n                    Acquired resistance to activated protein C has been reported during oral contraception and pregnancy. Its thrombogenic potential was studied in 41 neurosurgical pa tients who were enrolled in the placebo group of a thrombo prophylaxis trial. Normalized activated protein C sensitivity ratio (nAPC-SR), clotting activity of factors V and VIII, and levels of protein C antigen were measured prior to and at days 3 and 7 after surgery. Bilateral venography was done in all patients at days 8-10 to demonstrate deep vein thrombosis. A lowered nAPC-SR was found in 76% (baseline), 80% (day 3), and 88% (day 7) of patients. It was inversely related to factor VIII clotting activity (p = .0003) and protein C antigen, ( p = .02). Deep vein thrombosis was demonstrated in 30% of pa tients with a normal nAPC-SR and in 23% of patients with a lowered nAPC-SR. Pulmonary embolism was not observed. Multivariate analysis did not identify a lowered nAPC-SR as a thrombotic risk factor, in contrast with gender (women, p = .02) and Quetelet index (\u226525 kg\/m\n                    <jats:sup>2<\/jats:sup>\n                    , p = .006). Our data provide no evidence that acquired activated protein C resis tance, frequently found in neurosurgical patients, contributes to their high risk of postoperative deep vein thrombosis.\n                  <\/jats:p>","DOI":"10.1177\/107602969900500205","type":"journal-article","created":{"date-parts":[[2007,11,26]],"date-time":"2007-11-26T17:47:05Z","timestamp":1196099225000},"page":"105-109","source":"Crossref","is-referenced-by-count":0,"title":["State-of-the-Art Review : Acquired APC Resistance in Neurosurgical Patients May Not Be a Risk Factor for Postoperative Deep Vein Thrombosis"],"prefix":"10.1177","volume":"5","author":[{"given":"Johan R.","family":"Meinardi","sequence":"first","affiliation":[{"name":"Division of Hemostasis, Thrombosis and Rheology, University Hospital, Groningen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cilia M. A.","family":"Henkens","sequence":"additional","affiliation":[{"name":"Division of Hemostasis, Thrombosis and Rheology, University Hospital, Groningen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pieter-Jan","family":"de Kam","sequence":"additional","affiliation":[{"name":"Trial Coordination Centre, University Hospital, Groningen, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Van der Meer","sequence":"additional","affiliation":[{"name":"Division of Hemostasis, Thrombosis and Rheology, University Hospital, Groningen"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1999,4,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.3.1004"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199402243300801"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1038\/369064a0"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1648978"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1653788"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.1995.00271.x"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1097\/00001721-199703000-00011"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.1997.192707.x"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)63015-2"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1650250"},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.2307\/2529876"},{"key":"atypb12","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1649904"},{"key":"atypb13","doi-asserted-by":"publisher","DOI":"10.1159\/000206946"},{"key":"atypb14","doi-asserted-by":"publisher","DOI":"10.1159\/000188254"},{"key":"atypb15","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1647446"},{"key":"atypb16","doi-asserted-by":"publisher","DOI":"10.1016\/1053-0770(92)90051-8"},{"key":"atypb17","doi-asserted-by":"publisher","DOI":"10.1177\/0310057X9602400102"},{"key":"atypb18","doi-asserted-by":"publisher","DOI":"10.1227\/00006123-199403000-00001"},{"key":"atypb19","first-page":"9","volume":"56","author":"Hemker HC","year":"1995","journal-title":"Thromb Haemost"},{"key":"atypb20","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(94)90673-4"}],"container-title":["Clinical and Applied Thrombosis\/Hemostasis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/107602969900500205","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/107602969900500205","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T14:06:25Z","timestamp":1777385185000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/107602969900500205"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,4]]},"references-count":20,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1999,4]]}},"alternative-id":["10.1177\/107602969900500205"],"URL":"https:\/\/doi.org\/10.1177\/107602969900500205","relation":{},"ISSN":["1076-0296","1938-2723"],"issn-type":[{"value":"1076-0296","type":"print"},{"value":"1938-2723","type":"electronic"}],"subject":[],"published":{"date-parts":[[1999,4]]}}}