{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T14:23:16Z","timestamp":1785853396475,"version":"3.56.0"},"reference-count":43,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T00:00:00Z","timestamp":1753833600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Microbial Drug Resistance"],"published-print":{"date-parts":[[2025,8,1]]},"abstract":"<jats:p>\n                    <jats:italic toggle=\"yes\">Stenotrophomonas maltophilia<\/jats:italic>\n                    is an opportunistic, multidrug-resistant pathogen emerging in pediatric infections. Its intrinsic resistance to multiple antibiotics and genetic diversity complicates both the identification of this species and treatment strategies. We conducted genomic and phenotypic analyses of isolates of\n                    <jats:italic toggle=\"yes\">Stenotrophomonas<\/jats:italic>\n                    spp. from pediatric patients to assess species diversity through multilocus sequence typing and average nucleotide identity analyses. Antimicrobial susceptibility and resistance mechanisms, particularly the\n                    <jats:italic toggle=\"yes\">sul1<\/jats:italic>\n                    gene linked to sulfonamide resistance, were investigated. Our findings revealed multiple genomospecies. Of the isolates initially identified as\n                    <jats:italic toggle=\"yes\">S. maltophilia<\/jats:italic>\n                    using matrix-assisted laser desorption ionization\u2014time-of-flight mass spectrometry, only 58.5% were identified as such through molecular analyses. These other\n                    <jats:italic toggle=\"yes\">Stenotrophomonas<\/jats:italic>\n                    species may not be standardized for antimicrobial susceptibility testing by the Clinical and Laboratory Standards Institute and the European Committee on Antimicrobial Susceptibility and Testing. The\n                    <jats:italic toggle=\"yes\">sul1<\/jats:italic>\n                    gene, carried on a mobilized class 1 integron, emerged as the primary driver of trimethoprim-sulfamethoxazole resistance, raising concerns about the rapid dissemination of resistance traits. Our findings underscore the diagnostic and therapeutic challenges posed by\n                    <jats:italic toggle=\"yes\">Stenotrophomonas<\/jats:italic>\n                    spp. infections, highlighting the urgent need for enhanced molecular diagnostics for accurate species identification and resistance profiling. Continuous surveillance and updates to clinical guidelines are essential for improving infection management in pediatric patients.\n                  <\/jats:p>","DOI":"10.1177\/10766294251359795","type":"journal-article","created":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T17:11:13Z","timestamp":1759943473000},"page":"241-249","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Genetic Diversity of\n                    <i>Stenotrophomonas<\/i>\n                    spp. and Its Impact on Diagnosis and Treatment of Pediatric Infections"],"prefix":"10.1177","volume":"31","author":[{"given":"Luiza Souza","family":"Rodrigues","sequence":"first","affiliation":[{"name":"Instituto de Pesquisa Pel\u00e9 Pequeno Pr\u00edncipe (IPPPP), Curitiba, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hemanoel","family":"Passarelli-Araujo","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Center for Communicable Disease Dynamics, Harvard TH Chan School of Public Health, Boston, Massachusetts, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danieli","family":"Conte","sequence":"additional","affiliation":[{"name":"Instituto de Pesquisa Pel\u00e9 Pequeno Pr\u00edncipe (IPPPP), Curitiba, Brazil."},{"name":"Faculdades Pequeno Pr\u00edncipe (FPP), Curitiba, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tha\u00eds Muniz","family":"Vasconscelos","sequence":"additional","affiliation":[{"name":"Instituto de Pesquisa Pel\u00e9 Pequeno Pr\u00edncipe (IPPPP), Curitiba, Brazil."},{"name":"Faculdades Pequeno Pr\u00edncipe (FPP), Curitiba, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Damaris","family":"Krul","sequence":"additional","affiliation":[{"name":"Instituto de Pesquisa Pel\u00e9 Pequeno Pr\u00edncipe (IPPPP), Curitiba, Brazil."},{"name":"Faculdades Pequeno Pr\u00edncipe (FPP), Curitiba, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela","family":"Uessugui","sequence":"additional","affiliation":[{"name":"Instituto de Pesquisa Pel\u00e9 Pequeno Pr\u00edncipe (IPPPP), Curitiba, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatriz Nayra Dias de","family":"Andrade","sequence":"additional","affiliation":[{"name":"Faculdades Pequeno Pr\u00edncipe (FPP), Curitiba, Brazil."},{"name":"Hospital Pequeno Pr\u00edncipe (HPP), Curitiba, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriele Celine","family":"Siqueira","sequence":"additional","affiliation":[{"name":"Instituto de Pesquisa Pel\u00e9 Pequeno Pr\u00edncipe (IPPPP), Curitiba, Brazil."},{"name":"Faculdades Pequeno Pr\u00edncipe (FPP), Curitiba, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c9rika","family":"Medeiros dos Santos","sequence":"additional","affiliation":[{"name":"Hospital Pequeno Pr\u00edncipe (HPP), Curitiba, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marinei Campos","family":"Ricieri","sequence":"additional","affiliation":[{"name":"Hospital Pequeno Pr\u00edncipe (HPP), Curitiba, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F\u00e1bio de Ara\u00fajo","family":"Motta","sequence":"additional","affiliation":[{"name":"Hospital Pequeno Pr\u00edncipe (HPP), Curitiba, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Libera Maria","family":"Dalla-Costa","sequence":"additional","affiliation":[{"name":"Instituto de Pesquisa Pel\u00e9 Pequeno Pr\u00edncipe (IPPPP), Curitiba, Brazil."},{"name":"Faculdades Pequeno Pr\u00edncipe (FPP), Curitiba, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,7,30]]},"reference":[{"key":"e_1_3_8_2_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2017.02276"},{"key":"e_1_3_8_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/jacamr\/dlac040"},{"key":"e_1_3_8_4_2","doi-asserted-by":"crossref","first-page":"1325379","DOI":"10.3389\/fcimb.2023.1325379","article-title":"Stenotrophomonas maltophilia complex: Insights into evolutionary relationships, global distribution and pathogenicity","volume":"13","author":"Li K","year":"2023","unstructured":"Li K, , Yu K, , Huang Z, et al. Stenotrophomonas maltophilia complex: Insights into evolutionary relationships, global distribution and pathogenicity. Front Cell Infect Microbiol, 2023; 13(January):1325379.","journal-title":"Front Cell Infect Microbiol"},{"key":"e_1_3_8_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro2163"},{"issue":"8","key":"e_1_3_8_6_2","first-page":"e000207","article-title":"Taxonogenomics reveal multiple novel genomospecies associated with clinical isolates of Stenotrophomonas maltophilia","volume":"4","author":"Patil PP","year":"2018","unstructured":"Patil PP, , Kumar S, , Midha S, et al. Taxonogenomics reveal multiple novel genomospecies associated with clinical isolates of Stenotrophomonas maltophilia. 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Infectious Diseases Society of America 2023 Guidance on the treatment of antimicrobial resistant gram-negative infections. 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The igraph software package for complex network research. 2014;(May)."},{"key":"e_1_3_8_29_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-019-1832-y"},{"key":"e_1_3_8_30_2","doi-asserted-by":"publisher","DOI":"10.1093\/molbev\/mst010"},{"key":"e_1_3_8_31_2","doi-asserted-by":"publisher","DOI":"10.1080\/10635150701472164"},{"key":"e_1_3_8_32_2","doi-asserted-by":"publisher","DOI":"10.1002\/cpbi.96"},{"key":"e_1_3_8_33_2","volume-title":"Tabela de pontos de corte","author":"The Brazilian Committee on Antimicrobial Susceptibility Testing (BrCAST)","year":"2023","unstructured":"The Brazilian Committee on Antimicrobial Susceptibility Testing (BrCAST). Tabela de pontos de corte. 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