{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T11:21:53Z","timestamp":1787311313830,"version":"build-2736575974"},"reference-count":44,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Microbial Drug Resistance"],"published-print":{"date-parts":[[2025,10]]},"abstract":"\n Purpose:<\/jats:title>\n \n The Gram-negative bacterium\n Aeromonas caviae<\/jats:italic>\n is an important opportunistic facultative anaerobic pathogen. In the present study, we aimed to elucidate the whole-genome sequence of the multidrug-resistant (MDR)\n A. caviae<\/jats:italic>\n strain AC1520, detailing its acquired antibiotic resistance genes (ARGs) and their genetic elements.\n <\/jats:p>\n <\/jats:sec>\n \n Patients and Methods:<\/jats:title>\n \n The\n A. caviae<\/jats:italic>\n strain AC1520 was isolated from a urine sample taken from a patient with urinary tract infection. Whole-genome sequencing was performed following strain identification and antimicrobial susceptibility testing. Overall, we identified ARGs, integrons, insertion sequences (IS), and transposons acquired by strain AC1520, systematically analyzing the genetic elements associated with these ARGs.\n <\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n The\n A. caviae<\/jats:italic>\n strain AC1520 contained a circular chromosome and a plasmid. Multilocus sequence typing revealed that this strain belonged to ST-1056. All ARGs within this strain were distributed on the circular chromosome. We identified two MDR regions: (1) IS common region 1 (IS\n CR1<\/jats:italic>\n ) and class 1 integron (Int\n I1<\/jats:italic>\n ) elements associated with\n aadA16<\/jats:italic>\n ,\n aac(6\u2019)-Ib-cr<\/jats:italic>\n ,\n catB3<\/jats:italic>\n ,\n qacE<\/jats:italic>\n (two copies),\n sul1<\/jats:italic>\n (two copies), and\n \n bla\n PER-3<\/jats:sub>\n <\/jats:italic>\n ; one gene cluster structure (IS\n 6100<\/jats:italic>\n -\n mphR(A)<\/jats:italic>\n -\n mph(A)<\/jats:italic>\n -\n mrx(A)<\/jats:italic>\n -IS\n 26<\/jats:italic>\n ); (2) Two Int\n I1<\/jats:italic>\n elements, linked to\n ant(2\u2019\u2019)-Ia<\/jats:italic>\n ,\n \n bla\n OXA-10<\/jats:sub>\n <\/jats:italic>\n ,\n aadA2b<\/jats:italic>\n ,\n aph(3\u2032\u2019)-Ib<\/jats:italic>\n ,\n aph(6)-Id<\/jats:italic>\n ,\n ARR-2, aac(6\u2019)-Ib3, dfrA1, qacE,<\/jats:italic>\n and\n sul1<\/jats:italic>\n . Notably, these two MDR regions were not only present in\n A. caviae<\/jats:italic>\n but also in other bacteria, such as\n Aeromonas hydrophila<\/jats:italic>\n ,\n Aeromonas media<\/jats:italic>\n , and\n Edwardsiella tarda<\/jats:italic>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n \n The\n A. caviae<\/jats:italic>\n strain AC1520 with two separate MDR regions and 20 ARGs, conferring resistance to aminoglycoside, fluoroquinolone, phenicol, sulfonamide, beta-lactam, macrolide, rifampicin, and trimethoprim, was identified in a hospital in China. Mobile genetic elements including Tn\n As1<\/jats:italic>\n , IS\n CR1<\/jats:italic>\n , IS\n As25<\/jats:italic>\n , IS\n 6100<\/jats:italic>\n , IS\n 26<\/jats:italic>\n , Tn\n As3<\/jats:italic>\n , IS\n As1<\/jats:italic>\n , and Tn\n 3<\/jats:italic>\n , were found within the MDR region, which could play important roles in the global dissemination of these resistance genes.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1177\/10766294251374533","type":"journal-article","created":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T13:10:28Z","timestamp":1759842628000},"page":"309-316","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Whole-Genome Sequencing Analysis of the Multidrug-Resistant\n Aeromonas caviae<\/i>\n Strain AC1520 Isolated from a Patient with Urinary Tract Infection"],"prefix":"10.1177","volume":"31","author":[{"given":"Tao","family":"Xie","sequence":"first","affiliation":[{"name":"Department of Urology, Zhuhai People\u2019s Hospital (Zhuhai Clinical Medical College of Jinan University), Zhuhai, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junyong","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Urology, Zhuhai People\u2019s Hospital (Zhuhai Clinical Medical College of Jinan University), Zhuhai, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuangshuang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Outpatient, the Second People's Hospital of Xiangzhou District, Zhuhai, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinghuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Zhuhai People\u2019s Hospital (Zhuhai Clinical Medical College of Jinan University), Zhuhai, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiling","family":"Xia","sequence":"additional","affiliation":[{"name":"Department of Urology, Zhuhai People\u2019s Hospital (Zhuhai Clinical Medical College of Jinan University), Zhuhai, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiya","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Zhuhai People\u2019s Hospital (Zhuhai Clinical Medical College of Jinan University), Zhuhai, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuehua","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Urology, Zhuhai People\u2019s Hospital (Zhuhai Clinical Medical College of Jinan University), Zhuhai, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengqiu","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Urology, Zhuhai People\u2019s Hospital (Zhuhai Clinical Medical College of Jinan University), Zhuhai, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Urology, Zhuhai People\u2019s Hospital (Zhuhai Clinical Medical College of Jinan University), Zhuhai, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaobin","family":"Li","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Tumor Interventional Diagnosis and Treatment, Zhuhai People\u2019s Hospital (Zhuhai Clinical Medical College of Jinan University), Zhuhai, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Su","sequence":"additional","affiliation":[{"name":"Zhuhai Precision Medical Center, Zhuhai People\u2019s Hospital (Zhuhai Clinical Medical College of Jinan University), Zhuhai, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjun","family":"Ni","sequence":"additional","affiliation":[{"name":"Department of Urology, Zhuhai People\u2019s Hospital (Zhuhai Clinical Medical College of Jinan University), Zhuhai, China."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,10,6]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2010.12.003"},{"key":"e_1_3_3_3_2","volume-title":"Bergey\u2019s manual of systematic bacteriology","author":"Martin-Carnahan A","year":"2005","unstructured":"Martin-Carnahan A, , Joseph SW. 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Plasmid-mediated antimicrobial resistance in Salmonella enterica. 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