{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T22:07:57Z","timestamp":1777932477326,"version":"3.51.4"},"reference-count":20,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T00:00:00Z","timestamp":1768348800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Young and middle-aged talent research project of Fuzhou city","award":["2022-S-rc5"],"award-info":[{"award-number":["2022-S-rc5"]}]},{"name":"Fuzhou Health science and technology plan soft science research project","award":["2022-S-wr4"],"award-info":[{"award-number":["2022-S-wr4"]}]},{"name":"Natural fund project of Fujian Province","award":["2024J011223"],"award-info":[{"award-number":["2024J011223"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Microbial Drug Resistance"],"published-print":{"date-parts":[[2026,2,1]]},"abstract":"<jats:p>\n                    This study presents a case of\n                    <jats:italic toggle=\"yes\">Ralstonia mannitolilytica<\/jats:italic>\n                    isolated from a blood culture of a 50-year-old male patient with hepatocellular carcinoma. The patient underwent ultrasound-guided radiofrequency ablation for liver lesions associated with hepatocellular carcinoma and subsequently experienced recurrent fever, chills, and rigors.\n                    <jats:italic toggle=\"yes\">R. mannitolilytica<\/jats:italic>\n                    was identified from blood culture. This bacterium, known to be an opportunistic pathogen, has not been extensively studied for its whole-genome characteristics and resistance profiles. Through whole-genome sequencing and bioinformatics analysis, we identified 32 distinct drug resistance genes associated with various antibiotic classes, including\n                    <jats:italic toggle=\"yes\">beta-lactams<\/jats:italic>\n                    ,\n                    <jats:italic toggle=\"yes\">aminoglycosides<\/jats:italic>\n                    , and\n                    <jats:italic toggle=\"yes\">fluoroquinolones<\/jats:italic>\n                    . Our findings reveal the potential for multidrug resistance in\n                    <jats:italic toggle=\"yes\">R. mannitolilytica<\/jats:italic>\n                    , which exhibited numerous resistance genes. This underscores the clinical challenge of treating infections caused by this bacterium and highlights the importance of whole-genome analysis in understanding emerging pathogens. The identification of these resistance genes is crucial for devising effective clinical strategies to combat infections, particularly in immunocompromised patients, in whom the bacterium may pose a significant risk.\n                  <\/jats:p>","DOI":"10.1177\/10766294251411008","type":"journal-article","created":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T12:09:22Z","timestamp":1768392562000},"page":"64-70","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Whole-Genome Analysis of\n                    <i>Ralstonia mannitolilytica<\/i>\n                    in a Patient with Hepatocellular Carcinoma"],"prefix":"10.1177","volume":"32","author":[{"given":"Xiaoling","family":"Yu","sequence":"first","affiliation":[{"name":"Department of Pharmacy, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tianzhu","family":"Zhu","sequence":"additional","affiliation":[{"name":"Institute of Applied Genomics, Fuzhou University, Fuzhou, China."},{"name":"College of Biological Science and Engineering, Fuzhou University, Fuzhou, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenqian","family":"Jiang","sequence":"additional","affiliation":[{"name":"Institute of Applied Genomics, Fuzhou University, Fuzhou, China."},{"name":"College of Biological Science and Engineering, Fuzhou University, Fuzhou, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiawang","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Applied Genomics, Fuzhou University, Fuzhou, China."},{"name":"College of Biological Science and Engineering, Fuzhou University, Fuzhou, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Lin","sequence":"additional","affiliation":[{"name":"Institute of Applied Genomics, Fuzhou University, Fuzhou, China."},{"name":"College of Biological Science and Engineering, Fuzhou University, Fuzhou, China."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2026,1,14]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.20517\/2394-5079.2024.141"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-013-1975-9"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.2174\/1871526520666200330163504"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13256-019-2235-0"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.24151"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12890-023-02316-8"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.5414\/CNCS111202"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2010.03369.x"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13756-017-0178-z"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btw354"},{"key":"e_1_3_5_12_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0163962"},{"key":"e_1_3_5_13_2","doi-asserted-by":"publisher","DOI":"10.48550\/arXiv.1303.3997"},{"key":"e_1_3_5_14_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00483-19"},{"key":"e_1_3_5_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01310-13"},{"key":"e_1_3_5_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkw1004"},{"key":"e_1_3_5_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dks261"},{"key":"e_1_3_5_18_2","doi-asserted-by":"publisher","DOI":"10.1099\/mgen.0.000064"},{"key":"e_1_3_5_19_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkz1010"},{"key":"e_1_3_5_20_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02412-14"},{"key":"e_1_3_5_21_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bty266"}],"container-title":["Microbial 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