{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T22:07:53Z","timestamp":1777932473749,"version":"3.51.4"},"reference-count":29,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T00:00:00Z","timestamp":1767916800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["No.81700548"],"award-info":[{"award-number":["No.81700548"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Microbial Drug Resistance"],"published-print":{"date-parts":[[2026,3,1]]},"abstract":"<jats:p>\n                    Organ preservation solutions (PS) contaminated with multidrug-resistant bacteria (MDRB) risk donor-derived infections in transplantation. Eravacycline (ERV), a novel tetracycline antibiotic, shows potent activity against MDRB, but its efficacy in hypothermic PS (0\u00b0C\u20134\u00b0C) is unverified. In this study, six multidrug-resistant bacterial strains\u2014including carbapenem-resistant\n                    <jats:italic toggle=\"yes\">Klebsiella pneumoniae, Acinetobacter baumannii, Escherichia coli<\/jats:italic>\n                    , VIM-positive\n                    <jats:italic toggle=\"yes\">Pseudomonas aeruginosa<\/jats:italic>\n                    , carbapenemase-negative\n                    <jats:italic toggle=\"yes\">P. aeruginosa<\/jats:italic>\n                    , and methicillin-resistant\n                    <jats:italic toggle=\"yes\">Staphylococcus aureus<\/jats:italic>\n                    \u2014were exposed to eravacycline diluted in preservation solution at concentrations of 25, 50, 100, and 200 mg\/L for three hours at 0\u20134\u00b0C. Bacterial viability was assessed by colony-forming unit counts after incubation. Results showed that eravacycline at 25 mg\/L inhibited methicillin-resistant\n                    <jats:italic toggle=\"yes\">S. aureus<\/jats:italic>\n                    and carbapenem-resistant A. baumannii, while 50 mg\/L suppressed carbapenem-resistant\n                    <jats:italic toggle=\"yes\">K. pneumoniae, E. coli<\/jats:italic>\n                    , and VIM-positive\n                    <jats:italic toggle=\"yes\">P. aeruginosa<\/jats:italic>\n                    . Carbapenemase-negative\n                    <jats:italic toggle=\"yes\">P. aeruginosa<\/jats:italic>\n                    required 200 mg\/L for inhibition. These findings indicate that eravacycline exhibits strain-dependent antibacterial activity in hypothermic preservation solution, with 50 mg\/L being effective against most tested multidrug-resistant organisms except carbapenemase-negative\n                    <jats:italic toggle=\"yes\">P. aeruginosa<\/jats:italic>\n                    . Further clinical studies are warranted to evaluate its potential application in transplantation settings.\n                  <\/jats:p>","DOI":"10.1177\/10766294251411016","type":"journal-article","created":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T14:25:47Z","timestamp":1767968747000},"page":"75-81","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Study on the Decontamination Effect of Eravacycline on Multidrug-Resistant Bacteria in Hypothermic Organ Preservation Solution"],"prefix":"10.1177","volume":"32","author":[{"given":"Daqian","family":"Tang","sequence":"first","affiliation":[{"name":"Department of Organ Transplantation, Shanghai Changhai Hospital, The First Affiliated Hospital of Naval Medical University, Shanghai, China."},{"name":"Department of Urology, No 908th hospital of Chinese PLA Joint Logistic Support Force, Nanchang, Jiangxi, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanhua","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Organ Transplantation, Shanghai Changhai Hospital, The First Affiliated Hospital of Naval Medical University, Shanghai, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yazhe","family":"Duan","sequence":"additional","affiliation":[{"name":"Department of Organ Transplantation, Shanghai Changhai Hospital, The First Affiliated Hospital of Naval Medical University, Shanghai, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuhong","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Organ Transplantation, Shanghai Changhai Hospital, The First Affiliated Hospital of Naval Medical University, Shanghai, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Organ Transplantation, Shanghai Changhai Hospital, The First Affiliated Hospital of Naval Medical University, Shanghai, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuxiang","family":"Wan","sequence":"additional","affiliation":[{"name":"Clinical Laboratory, Shanghai Changhai Hospital, The First Affiliated Hospital of Naval Medical University, Shanghai, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kang","family":"Wu","sequence":"additional","affiliation":[{"name":"Clinical Laboratory, Shanghai Changhai Hospital, The First Affiliated Hospital of Naval Medical University, Shanghai, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanfeng","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Organ Transplantation, Shanghai Changhai Hospital, The First Affiliated Hospital of Naval Medical University, Shanghai, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenyu","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Organ Transplantation, Shanghai Changhai Hospital, The First Affiliated Hospital of Naval Medical University, Shanghai, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junhao","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Organ Transplantation, Shanghai Changhai Hospital, The First Affiliated Hospital of Naval Medical University, Shanghai, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Organ Transplantation, Shanghai Changhai Hospital, The First Affiliated Hospital of Naval Medical University, Shanghai, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingxing","family":"Sui","sequence":"additional","affiliation":[{"name":"Department of Organ 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