{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T13:47:59Z","timestamp":1785937679984,"version":"3.56.0"},"reference-count":77,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T00:00:00Z","timestamp":1780876800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100009694","name":"Bu-Ali Sina University","doi-asserted-by":"crossref","award":["402169"],"award-info":[{"award-number":["402169"]}],"id":[{"id":"10.13039\/501100009694","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Microbial Drug Resistance"],"published-print":{"date-parts":[[2026,8,1]]},"abstract":"<jats:p>\n                    The current study was conducted to determine the antibiotic resistance profile and prevalence of extended-spectrum \u03b2-lactamases (ESBLs)-producing\n                    <jats:italic toggle=\"yes\">Escherichia coli<\/jats:italic>\n                    among the uropathogenic\n                    <jats:italic toggle=\"yes\">E. coli<\/jats:italic>\n                    (UPEC) strains (\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    = 100), isolated from patients with urinary tract infection (UTI) in Hamedan, western Iran. In addition, the molecular prevalence of antibiotic resistance genes (ARGs) and ESBL genes among these strains was investigated using polymerase chain reaction. Out of 100 UPEC isolates, 46 (46%) and 40 (40%) isolates were phenotypically identified as multidrug-resistance (MDR) strains and ESBLs producer strains, respectively. UPEC isolates showed the highest resistance to trimethoprim\/sulfamethoxazole (55%), followed by amoxicillin (51%) and ampicillin (45%). The most prevalent ARG in UPEC strains was\n                    <jats:italic toggle=\"yes\">tetA<\/jats:italic>\n                    (10%), followed by\n                    <jats:italic toggle=\"yes\">aadA1<\/jats:italic>\n                    (9%),\n                    <jats:italic toggle=\"yes\">sul1<\/jats:italic>\n                    (9%),\n                    <jats:italic toggle=\"yes\">qnrs<\/jats:italic>\n                    (7%), and\n                    <jats:italic toggle=\"yes\">dfrA1-like<\/jats:italic>\n                    (3%). Among the 40 UPEC isolates that phenotypically confirmed as ESBL producers, 19 (475%) isolates harbored\n                    <jats:italic toggle=\"yes\">bla<\/jats:italic>\n                    <jats:sub>CTX-<\/jats:sub>\n                    <jats:italic toggle=\"yes\">\n                      <jats:sub>M<\/jats:sub>\n                    <\/jats:italic>\n                    gene, 9 (22.5%) harbored\n                    <jats:italic toggle=\"yes\">bla<\/jats:italic>\n                    <jats:sub>TEM<\/jats:sub>\n                    gene, 8 (20%) harbored\n                    <jats:italic toggle=\"yes\">bla<\/jats:italic>\n                    <jats:sub>OXA<\/jats:sub>\n                    gene, and 4 (10%) harbored\n                    <jats:italic toggle=\"yes\">bla<\/jats:italic>\n                    <jats:sub>CIT-<\/jats:sub>\n                    <jats:italic toggle=\"yes\">\n                      <jats:sub>M<\/jats:sub>\n                    <\/jats:italic>\n                    . The ESBL gene\n                    <jats:italic toggle=\"yes\">bla<\/jats:italic>\n                    <jats:sub>CTX-<\/jats:sub>\n                    <jats:italic toggle=\"yes\">\n                      <jats:sub>M<\/jats:sub>\n                    <\/jats:italic>\n                    displayed a significant association with ESBL phenotypic isolates at\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    value &lt;0.05. Due to the relatively high prevalence of MDR-UPEC strains and ESBLs producer UPEC isolates among patients with UTI reported herein and also regarding incidence of ARGs and \u03b2-lactamase gene among these isolates, applying precise antibiotic stewardship, continuous surveillance to use appropriate antibiotics, and the control of UTI infections seem necessary to decrease ESBLs producer UPEC and MDR-UPEC strains.\n                  <\/jats:p>","DOI":"10.1177\/10766294261426668","type":"journal-article","created":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T12:00:23Z","timestamp":1780920023000},"page":"285-294","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["High Prevalence of Multidrug-Resistance and Extended-Spectrum-\u03b2-Lactamases-Producing\n                    <i>Escherichia coli<\/i>\n                    Isolated from Patients with Urinary Tract Infection in Hamedan, Iran"],"prefix":"10.1177","volume":"32","author":[{"given":"Ali","family":"Goudarztalejerdi","sequence":"first","affiliation":[{"name":"Department of Pathobiology, Faculty of Veterinary Medicine, Bu-Ali Sina University, Hamedan, Iran."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mozhdeh","family":"Zolfaghari","sequence":"additional","affiliation":[{"name":"Department of Pathobiology, Faculty of Veterinary Medicine, Bu-Ali Sina University, Hamedan, Iran."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zahra","family":"Rahimifar","sequence":"additional","affiliation":[{"name":"Department of Pathobiology, Faculty of Veterinary Medicine, Bu-Ali Sina University, Hamedan, Iran."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pezhman","family":"Mahmoodi","sequence":"additional","affiliation":[{"name":"Department of Pathobiology, Faculty of Veterinary Medicine, Bu-Ali Sina University, Hamedan, Iran."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatemeh","family":"Sarvestani","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Iranian Social Security Organization, Atiyeh Hospital, Hamedan, Iran."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,6,8]]},"reference":[{"key":"e_1_3_5_2_1","doi-asserted-by":"publisher","DOI":"10.1089\/mdr.2020.0432"},{"key":"e_1_3_5_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro3432"},{"key":"e_1_3_5_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000441-199710000-00007"},{"key":"e_1_3_5_5_1","doi-asserted-by":"publisher","DOI":"10.3855\/jidc.14217"},{"key":"e_1_3_5_6_1","unstructured":"5.Griffin PR. 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