{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T16:11:58Z","timestamp":1779120718296,"version":"3.51.4"},"reference-count":17,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T00:00:00Z","timestamp":1773100800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Microbial Drug Resistance"],"published-print":{"date-parts":[[2026,6,1]]},"abstract":"<jats:p>\n                    This study analyzed factors associated with mortality in\n                    <jats:italic toggle=\"yes\">Klebsiella pneumoniae<\/jats:italic>\n                    bacteremia, particularly the role of combination therapy. Medical records of 109 patients (2012\u20132018) were reviewed to assess risk factors for carbapenem-resistant\n                    <jats:italic toggle=\"yes\">K. pneumoniae<\/jats:italic>\n                    (CRKP) bacteremia. The total 30-day mortality was 41.3%. Excess mortality was calculated for the following groups: multidrug-resistant (MDR)\n                    <jats:italic toggle=\"yes\">K. pneumoniae<\/jats:italic>\n                    , CRKP, and carbapenem-susceptible\n                    <jats:italic toggle=\"yes\">K. pneumoniae<\/jats:italic>\n                    . Of 109 isolates, 64.2% were CRKP. All patients received empirical therapy; 20.2% received monotherapy, while the remainder received combination therapy, which was linked to longer intensive care unit stays and higher primary bacteremia rates. Overall, inappropriate empirical treatment occurred in 62.4% of patients. Both monotherapy (40.9%) and combination therapy (36.8%) groups showed similarly high rates of inappropriate treatment. Hemodialysis catheter use was a risk factor (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    = 0.0238). Third- and fourth-generation cephalosporins had the highest mortality (45.9%), whereas MDR strains showed the lowest (4.51%). Although combination therapy alone did not significantly reduce mortality, Kaplan\u2013Meier analysis revealed no survival benefit. However, monotherapy increased mortality, suggesting that combination therapy may still play a role in mitigating outcomes. Carbapenem resistance in\n                    <jats:italic toggle=\"yes\">K. pneumoniae<\/jats:italic>\n                    bacteremia remains alarmingly high and correlates with excess mortality and inappropriate empirical treatment.\n                  <\/jats:p>","DOI":"10.1177\/10766294261426670","type":"journal-article","created":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T12:56:32Z","timestamp":1773233792000},"page":"202-208","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Mortality Associated with Bacteremia Caused by Carbapenem-Resistant\n                    <i>Klebsiella pneumoniae<\/i>\n                    : The Crucial Role of Therapy in Clinical Outcome"],"prefix":"10.1177","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-6876-6474","authenticated-orcid":false,"given":"Camila","family":"Peredo Ramirez","sequence":"first","affiliation":[{"name":"Laboratory of Molecular Microbiology, Institute of Biomedical Sciences, Federal University of Uberl\u00e2ndia, Uberl\u00e2ndia, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elias","family":"Rodrigues de Almeida-Junior","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Microbiology, Institute of Biomedical Sciences, Federal University of Uberl\u00e2ndia, Uberl\u00e2ndia, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vin\u00edcius Lopes","family":"Dias","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Microbiology, Institute of Biomedical Sciences, Federal University of Uberl\u00e2ndia, Uberl\u00e2ndia, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosineide Marques","family":"Ribas","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Microbiology, Institute of Biomedical Sciences, Federal University of Uberl\u00e2ndia, Uberl\u00e2ndia, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2026,3,10]]},"reference":[{"key":"e_1_3_5_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciad100"},{"key":"e_1_3_5_3_1","doi-asserted-by":"publisher","DOI":"10.1017\/ice.2024.21"},{"key":"e_1_3_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgar.2024.06.007"},{"key":"e_1_3_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2666-5247(24)00018-1"},{"key":"e_1_3_5_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s42770-024-01299-w"},{"key":"e_1_3_5_7_1","doi-asserted-by":"publisher","DOI":"10.1590\/0037-8682-0471-2016"},{"key":"e_1_3_5_8_1","doi-asserted-by":"publisher","DOI":"10.1590\/0037-8682-0064-2020"},{"key":"e_1_3_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2018.02.007"},{"key":"e_1_3_5_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics11070874"},{"key":"e_1_3_5_11_1","doi-asserted-by":"publisher","DOI":"10.2147\/IDR.S48810"},{"key":"e_1_3_5_12_1","doi-asserted-by":"publisher","DOI":"10.1086\/668770"},{"key":"e_1_3_5_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciz414"},{"key":"e_1_3_5_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00284-023-03403-z"},{"key":"e_1_3_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(13)70190-7"},{"key":"e_1_3_5_16_1","doi-asserted-by":"publisher","DOI":"10.1128\/spectrum.00374-23"},{"key":"e_1_3_5_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-71660-4"},{"key":"e_1_3_5_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jointm.2022.10.001"}],"container-title":["Microbial Drug Resistance"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10766294261426670","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/10766294261426670","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10766294261426670","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T15:45:14Z","timestamp":1779119114000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/10766294261426670"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,10]]},"references-count":17,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6,1]]}},"alternative-id":["10.1177\/10766294261426670"],"URL":"https:\/\/doi.org\/10.1177\/10766294261426670","relation":{},"ISSN":["1076-6294","1931-8448"],"issn-type":[{"value":"1076-6294","type":"print"},{"value":"1931-8448","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,10]]}}}