{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T17:59:23Z","timestamp":1783533563564,"version":"3.55.0"},"reference-count":57,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T00:00:00Z","timestamp":1772668800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Microbial Drug Resistance"],"published-print":{"date-parts":[[2026,6,1]]},"abstract":"<jats:p>\n                    Methicillin-resistant\n                    <jats:italic toggle=\"yes\">Staphylococcus aureus<\/jats:italic>\n                    (MRSA), a critical pathogen according to the World Health Organization, requires new treatments and resistance surveillance. This study compared the antibiotic susceptibility of clinical methicillin-susceptible\n                    <jats:italic toggle=\"yes\">S. aureus<\/jats:italic>\n                    (MSSA) and MRSA isolates to last-line agents, including teicoplanin, linezolid, and daptomycin. A total of 134\n                    <jats:italic toggle=\"yes\">S. aureus<\/jats:italic>\n                    strains isolated from skin and soft tissue infections (SSTIs) were confirmed by detecting the\n                    <jats:italic toggle=\"yes\">nuc<\/jats:italic>\n                    gene via PCR. MRSA and MSSA were identified by cefoxitin disk diffusion and confirmed by\n                    <jats:italic toggle=\"yes\">mecA<\/jats:italic>\n                    gene amplification. Antibiotic susceptibility was initially screened by the Kirby\u2013Bauer disk diffusion method, with minimum inhibitory concentrations (MICs) of last-resort antibiotics (teicoplanin, linezolid, and daptomycin) precisely determined by broth microdilution. Multidrug-resistant (MDR) phenotypes were defined as resistance to \u22652 non-\u03b2-lactam antimicrobial classes for MRSA and \u22653 for MSSA. Statistical analyses were conducted with chi-square and Fisher\u2019s exact tests. MRSA isolates exhibited significantly greater resistance than MSSA to cefazolin, gentamicin, amikacin, azithromycin, tetracycline, clindamycin, ciprofloxacin, and teicoplanin (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    &lt; 0.05). While daptomycin remained highly effective (96.3% susceptibility), concerning rates of non-susceptibility were observed for linezolid (41%) and teicoplanin (15.7%), primarily among MRSA isolates. Overall, MDR was prevalent in 41.7% of the\n                    <jats:italic toggle=\"yes\">S. aureus<\/jats:italic>\n                    isolates. Daptomycin and cefazolin remain effective against MRSA and MSSA SSTIs, respectively. However, emerging resistance to last-line agents such as teicoplanin and linezolid is alarming and necessitates enhanced surveillance, prudent antibiotic use, and increased antimicrobial research to counter the growing threat of antibiotic resistance.\n                  <\/jats:p>","DOI":"10.1177\/10766294261426677","type":"journal-article","created":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T13:06:09Z","timestamp":1773234369000},"page":"193-201","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Emergence of Teicoplanin and Linezolid Resistance in Clinical Isolates of Methicillin-Resistant and -Susceptible\n                    <i>Staphylococcus aureus<\/i>"],"prefix":"10.1177","volume":"32","author":[{"given":"Zeinab","family":"Fagheei Aghmiyuni","sequence":"first","affiliation":[{"name":"Department of Microbiology, Faculty of Medicine, Shahed University, Tehran, Iran."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Hossein","family":"Ahmadi","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Faculty of Medicine, Shahed University, Tehran, Iran."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Horieh","family":"Saderi","sequence":"additional","affiliation":[{"name":"Molecular Microbiology Research Center, Faculty of Medicine, Shahed University, Tehran, Iran."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,3,5]]},"reference":[{"key":"e_1_3_6_2_1","doi-asserted-by":"publisher","DOI":"10.2147\/IDR.S428103"},{"key":"e_1_3_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgar.2017.05.019"},{"key":"e_1_3_6_4_1","doi-asserted-by":"publisher","DOI":"10.1128\/aac.01542-18"},{"key":"e_1_3_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)02724-0"},{"key":"e_1_3_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/iub.1289"},{"key":"e_1_3_6_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2020.00107"},{"key":"e_1_3_6_8_1","first-page":"12","volume-title":"Bacterial priority pathogens list","author":"WHO","year":"2024","unstructured":"7.WHO. Bacterial priority pathogens list. Geneva: World Health Organization (WHO) 2024;12\u201313."},{"key":"e_1_3_6_9_1","doi-asserted-by":"publisher","DOI":"10.1128\/aac.02397-17"},{"key":"e_1_3_6_10_1","doi-asserted-by":"publisher","DOI":"10.5812\/iji.104447"},{"key":"e_1_3_6_11_1","first-page":"2163","article-title":"Novel mutation sites in the development of vancomycin-intermediate resistance in Staphylococcus aureus","volume":"7","author":"Wang Y","year":"2016","unstructured":"10.Wang Y, , Li X, , Jiang L, et al. Novel mutation sites in the development of vancomycin-intermediate resistance in Staphylococcus aureus. 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