{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T16:05:05Z","timestamp":1791475505978,"version":"4.3.4"},"reference-count":29,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T00:00:00Z","timestamp":1772668800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Microbial Drug Resistance"],"published-print":{"date-parts":[[2026,4,1]]},"abstract":"<jats:p>\n                    Cefiderocol (FDC) shows promise against carbapenem resistance, with differing carbapenemase epidemiology across Southeast and East Asia, including India. This study evaluated the susceptibility of carbapenem-resistant\n                    <jats:italic toggle=\"yes\">Klebsiella pneumoniae<\/jats:italic>\n                    (CRKP) and carbapenem-resistant\n                    <jats:italic toggle=\"yes\">Acinetobacter baumannii<\/jats:italic>\n                    (CRAB) against FDC and assessed carbapenemase genetic influences on susceptibility. A total of 100 clinical isolates of CRAB and 100 clinical isolates of CRKP were studied. The minimum inhibitory concentration for FDC, ceftazidime\u2013avibactam (CZA), aztreonam, polymyxins in CRKP, and polymyxins and minocycline in CRAB was determined by the broth microdilution method. Carbapenemases were detected using the ethylenediaminetetraacetic acid-modified carbapenem inactivation method in CRKP and the modified Hodge test for CRAB. The confirmation of carbapenemases (\n                    <jats:italic toggle=\"yes\">bla<\/jats:italic>\n                    <jats:sub>SME<\/jats:sub>\n                    ,\n                    <jats:italic toggle=\"yes\">bla<\/jats:italic>\n                    <jats:sub>NMC<\/jats:sub>\n                    ,\n                    <jats:italic toggle=\"yes\">bla<\/jats:italic>\n                    <jats:sub>GES<\/jats:sub>\n                    ,\n                    <jats:italic toggle=\"yes\">bla<\/jats:italic>\n                    <jats:sub>KPC<\/jats:sub>\n                    ,\n                    <jats:italic toggle=\"yes\">bla<\/jats:italic>\n                    <jats:sub>IMP<\/jats:sub>\n                    ,\n                    <jats:italic toggle=\"yes\">bla<\/jats:italic>\n                    <jats:sub>VIM<\/jats:sub>\n                    , and\n                    <jats:italic toggle=\"yes\">bla<\/jats:italic>\n                    <jats:sub>NDM<\/jats:sub>\n                    for all;\n                    <jats:italic toggle=\"yes\">bla<\/jats:italic>\n                    <jats:sub>OXA-48<\/jats:sub>\n                    in CRKP; and\n                    <jats:italic toggle=\"yes\">bla<\/jats:italic>\n                    <jats:sub>OXA-23 like<\/jats:sub>\n                    <jats:italic toggle=\"yes\">bla<\/jats:italic>\n                    <jats:sub>OXA-24\/40<\/jats:sub>\n                    and\n                    <jats:italic toggle=\"yes\">bla<\/jats:italic>\n                    <jats:sub>OXA-58<\/jats:sub>\n                    in CRAB) was performed by multiplex PCR. FDC resistance in CRKP and CRAB was 1% and 6%, respectively. CRKP isolates showed significant resistance to polymyxin B (31%), colistin (21%), aztreonam (34%), and CZA (41%;\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    &lt; 0.05) as compared to FDC, while CRAB isolates exhibited higher FDC resistance (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    &lt; 0.05). Moreover, 96% of CRKP and 100% of CRAB were carbapenemase producers. For CRKP,\n                    <jats:italic toggle=\"yes\">bla<\/jats:italic>\n                    <jats:sub>OXA-48<\/jats:sub>\n                    +\n                    <jats:italic toggle=\"yes\">bla<\/jats:italic>\n                    <jats:sub>NDM<\/jats:sub>\n                    combination and for CRAB,\n                    <jats:italic toggle=\"yes\">bla<\/jats:italic>\n                    <jats:sub>NDM<\/jats:sub>\n                    was significantly associated with FDC resistance. The study revealed the presence of\n                    <jats:italic toggle=\"yes\">bla<\/jats:italic>\n                    <jats:sub>NDM<\/jats:sub>\n                    as one of the causes for reduced susceptibility to FDC in these isolates.\n                  <\/jats:p>","DOI":"10.1177\/10766294261426703","type":"journal-article","created":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T13:07:41Z","timestamp":1773234461000},"page":"111-118","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Susceptibility of Carbapenem-Resistant\n                    <i>Acinetobacter baumannii<\/i>\n                    and Carbapenem-Resistant\n                    <i>Klebsiella pneumoniae<\/i>\n                    Against Cefiderocol with Reference to Their Genetic Profile in India"],"prefix":"10.1177","volume":"32","author":[{"given":"Tuhina","family":"Banerjee","sequence":"first","affiliation":[{"name":"Department of Microbiology, Institute of Medical Sciences, BHU, Varanasi, India."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kajal","family":"Mishra","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Institute of Medical Sciences, BHU, Varanasi, India."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pue","family":"Rakshit","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Institute of Medical Sciences, BHU, Varanasi, India."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Swati","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Institute of Medical Sciences, BHU, Varanasi, India."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rahul","family":"Garg","sequence":"additional","affiliation":[{"name":"Department of Microbiology, All India Institute of Medical Sciences, Raipur, India."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Padma","family":"Das","sequence":"additional","affiliation":[{"name":"Department of Microbiology, All India Institute of Medical Sciences, Raipur, India."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amitabha","family":"Bhattacharjee","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Assam University, Silchar, India."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simit","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Rampurhat Government Medical College &amp; Hospital, Rampurhat, India."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajesh","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Institute of Medical Sciences, BHU, Varanasi, India."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shampa","family":"Anupurba","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Institute of Medical Sciences, BHU, Varanasi, India."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,3,5]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2020.05.126"},{"key":"e_1_3_5_3_2","unstructured":"World Health Organization Press. Global priority list of antibiotic-resistant bacteria to guide research discovery and development of new antibiotics. 2017. Available from: https:\/\/www.who.int\/news\/item\/27-02-2017-who-publishes-list-of-bacteria-for-which-new-antibiotics-are-urgently-needed [Last accessed: July13 2023]."},{"key":"e_1_3_5_4_2","unstructured":"WHO Country Office for India. Department of Biotechnology Government of India. Indian Priority pathogen list: To guide research discovery and development of new antibiotics in India. World Health Organization: Geneva Switzerland; 2021. 1\u201322. 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Clinical and Laboratory Standards Institute: Wayne, PA; 2015; p. 24. [May 7, 2024]."},{"key":"e_1_3_5_17_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00951-20"},{"key":"e_1_3_5_18_2","first-page":"174","volume-title":"CLSI supplement M100, 33rd edition. Table 3D: Tests for colistin resistance in Enterobactarales","author":"Clinical L","year":"2023","unstructured":"Clinical L, , Standards I. \u201cPerformance standard for antimicrobial susceptibility\u201d. In CLSI supplement M100, 33rd edition. Table 3D: Tests for colistin resistance in Enterobactarales. Clinical and Laboratory Standards Institute: Wayne, PA; 2023; p. 174. [September 6, 2024]."},{"key":"e_1_3_5_19_2","first-page":"162","volume-title":"Table 3C: Modified Carbapenem Inactivation Methods for Suspected Carbapenemase Production in Enterobactarales","author":"Clinical Laboratory and Standards Institute","year":"2023","unstructured":"Clinical Laboratory and Standards Institute. \u201cPerformance standard for antimicrobial susceptibility\u201d in CLSI supplement M100, 33rd edition. Table 3C: Modified Carbapenem Inactivation Methods for Suspected Carbapenemase Production in Enterobactarales. Clinical and Laboratory Standards Institute, Wayne, PA; 2023; p. 162. 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