{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T22:08:11Z","timestamp":1777932491227,"version":"3.51.4"},"reference-count":16,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T00:00:00Z","timestamp":1773619200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Microbial Drug Resistance"],"published-print":{"date-parts":[[2026,5,1]]},"abstract":"<jats:p>\n                    Antimicrobial resistance remains a major threat to global public health, with increasing reports of the spread of \u03b2-lactamase genes posing significant risks. The number of\n                    <jats:italic toggle=\"yes\">Enterobacteriaceae<\/jats:italic>\n                    harboring plasmid-mediated AmpC enzymes has been rising worldwide, with prevalence rates varying across regions. These \u03b2-lactamases are of particular epidemiological concern because they confer resistance to several \u03b2-lactam antibiotics, including penicillins, second and third-generation cephalosporins, and monobactams, while isolates typically remain susceptible to cefepime and carbapenems. This study reports, for the first time in Brazil, the detection of the\n                    <jats:italic toggle=\"yes\">\n                      bla\n                      <jats:sub>ACT-5<\/jats:sub>\n                    <\/jats:italic>\n                    gene in a\n                    <jats:italic toggle=\"yes\">Klebsiella pneumoniae<\/jats:italic>\n                    isolate recovered from a community-acquired infection clinical sample in Rio de Janeiro, which notably exhibited resistance to both cefepime and carbapenems.\n                  <\/jats:p>","DOI":"10.1177\/10766294261426732","type":"journal-article","created":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T10:08:00Z","timestamp":1773655680000},"page":"172-176","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["First Report of\n                    <i>Klebsiella pneumoniae<\/i>\n                    Clinical Isolates Carrying\n                    <i>pAmpc<\/i>\n                    Gene ACT-5 with Reduced Sensitivity to Cefepime from Brazil"],"prefix":"10.1177","volume":"32","author":[{"given":"Bianca Azeredo","family":"Mello","sequence":"first","affiliation":[{"name":"Funda\u00e7\u00e3o Oswaldo Cruz, Instituto Nacional de Controle de Qualidade em Sa\u00fade, Rio de Janeiro, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Carolina Carvalho","family":"de Oliveira Macedo","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Oswaldo Cruz, Instituto Nacional de Controle de Qualidade em Sa\u00fade, Rio de Janeiro, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicolle Felix Lima","family":"Nunes","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Oswaldo Cruz, Instituto Nacional de Controle de Qualidade em Sa\u00fade, Rio de Janeiro, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angelica Nogueira","family":"Miranda","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Oswaldo Cruz, Instituto Nacional de Controle de Qualidade em Sa\u00fade, Rio de Janeiro, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah Ribeiro Fernandes","family":"de Sousa","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Oswaldo Cruz, Instituto Nacional de Controle de Qualidade em Sa\u00fade, Rio de Janeiro, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wellington Luiz Pontes","family":"da Silva","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Oswaldo Cruz, Instituto Nacional de Controle de Qualidade em Sa\u00fade, Rio de Janeiro, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Debora Ribeiro","family":"de Souza Santos","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Oswaldo Cruz, Instituto Nacional de Controle de Qualidade em Sa\u00fade, Rio de Janeiro, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivano","family":"de Filippis","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Oswaldo Cruz, Instituto Nacional de Controle de Qualidade em Sa\u00fade, Rio de Janeiro, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2026,3,16]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms10030611"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13756-020-00856-w"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetmic.2018.05.017"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.3168\/jds.2017-13878"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-024-04820-7"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciz173"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00036-08"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-15666-2"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0218589"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.48.10.3720-3728.2004"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00079-17"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2025.1529157"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/femsre\/fux013"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2006.08.023"},{"key":"e_1_3_3_16_2","volume-title":"EUCAST guidelines for detection of resistance mechanisms and specific resistances of clinical and\/or epidemiological importance","author":"EUCAST","year":"2017","unstructured":"EUCAST. EUCAST guidelines for detection of resistance mechanisms and specific resistances of clinical and\/or epidemiological importance. EUCAST; 2017."},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.40.6.2153-2162.2002"}],"container-title":["Microbial Drug Resistance"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10766294261426732","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/10766294261426732","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10766294261426732","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T01:20:43Z","timestamp":1777684843000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/10766294261426732"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,16]]},"references-count":16,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5,1]]}},"alternative-id":["10.1177\/10766294261426732"],"URL":"https:\/\/doi.org\/10.1177\/10766294261426732","relation":{},"ISSN":["1076-6294","1931-8448"],"issn-type":[{"value":"1076-6294","type":"print"},{"value":"1931-8448","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,16]]}}}