{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T20:20:45Z","timestamp":1792095645601,"version":"4.4.0"},"reference-count":29,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T00:00:00Z","timestamp":1772755200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Microbial Drug Resistance"],"published-print":{"date-parts":[[2026,5,1]]},"abstract":"\n Background and Objectives:<\/jats:title>\n \n Staphylococcus aureus<\/jats:italic>\n infection and its antibiotic resistance (ABR) situation are topical concerns. To formulate an effective response strategy tailored to our hospital and provide clinicians with a reliable basis for empirical antimicrobial use in the early phases of treatment.\n <\/jats:p>\n <\/jats:sec>\n \n Method:<\/jats:title>\n \n Between 2014 and 2023, a total of 11,886\n S. aureus<\/jats:italic>\n isolates and 3,417 methicillin-resistant\n S. aureus<\/jats:italic>\n (MRSA) isolates were enrolled. The distribution of these isolates over the 10-year period was analyzed, along with trends in ABR among all\n S. aureus<\/jats:italic>\n isolates, those from respiratory tract specimens, those from pediatric patients, and MRSA isolates.\n <\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n The detection number of\n S. aureus<\/jats:italic>\n and MRSA strains showed an increasing trend over the 10-year period. However, while the proportion of\n S. aureus<\/jats:italic>\n among Gram-positive strains (G+) remained stable, its proportion among all bacterial pathogens (BPS) decreased.\n S. aureus<\/jats:italic>\n and MRSA strains were primarily isolated from respiratory tract specimens, wound pus, and blood specimens. The top three departments with the highest detection rates of\n S. aureus<\/jats:italic>\n were Pediatrics, Pediatric Surgery, and Orthopedics, in order. Resistance rates to oxacillin and penicillin G were nearly universal, approaching 100%. In contrast, resistance to gentamicin, rifampicin, ciprofloxacin, levofloxacin, moxifloxacin, cotrimoxazole, clindamycin, erythromycin, and tetracycline showed different downward trends across the four study groups.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n \n In conclusion, the prevalence of\n S. aureus<\/jats:italic>\n infections within our hospital remains a significant concern. It is imperative to closely monitor the epidemiological distribution and ABR patterns of this pathogen to facilitate early intervention and guide appropriate therapeutic strategies.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1177\/10766294261426734","type":"journal-article","created":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T15:15:29Z","timestamp":1773242129000},"page":"141-150","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Distribution and Antibiotic Resistance Trends of\n Staphylococcus aureus<\/i>\n : A 10-Year Retrospective Study"],"prefix":"10.1177","volume":"32","author":[{"given":"Yan","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Clinical Laboratory, Mianyang Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Mianyang, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengjun","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Medical Insurance, Mianyang Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Mianyang, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yisheng","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Mianyang Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Mianyang, China."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,3,6]]},"reference":[{"key":"e_1_3_5_2_2","volume-title":"Bacterial Priority Pathogens List, 2024: Bacterial Pathogens of Public Health Importance to Guide Research, Development and Strategies to Prevent and Control Antimicrobial Resistance","author":"WHO","year":"2024","unstructured":"WHO. Bacterial Priority Pathogens List, 2024: Bacterial Pathogens of Public Health Importance to Guide Research, Development and Strategies to Prevent and Control Antimicrobial Resistance. World Health Organization: Geneva; 2024."},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(24)01867-1"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)02724-0"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.idc.2021.07.001"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmjgh-2018-001315"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid2505.181773"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1004301"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2020.00127"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.000635"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2023.06.009"},{"issue":"06","key":"e_1_3_5_12_2","first-page":"627","article-title":"CHINET surveillance of antimicrobial resistance among the bacterial isolates in 2023","volume":"24","author":"Guo Y","year":"2024","unstructured":"Guo Y, , Hu FP, , Zhu DM, et al. CHINET surveillance of antimicrobial resistance among the bacterial isolates in 2023. Chin. J. Infect. Chemother, 2024; 24(06):627\u2013637; doi: 10.16718\/j.1009-7708.2024.06.001","journal-title":"Chin. J. Infect. Chemother"},{"key":"e_1_3_5_13_2","doi-asserted-by":"publisher","DOI":"10.2147\/IDR.S421357"},{"key":"e_1_3_5_14_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2023.1220363"},{"key":"e_1_3_5_15_2","doi-asserted-by":"publisher","DOI":"10.2147\/IDR.S423580"},{"issue":"6","key":"e_1_3_5_16_2","first-page":"2724","article-title":"Analysis of clinical characteristics and drug resistance of Staphylococcus aureus nosocomial infection","volume":"77","author":"Li M","year":"2022","unstructured":"Li M, , Cui L, , Jiao K, et al. Analysis of clinical characteristics and drug resistance of Staphylococcus aureus nosocomial infection. Minerva Surg, 2022; 77(6):2724\u20135691; doi: 10.23736\/S2724-5691.21.09199-1","journal-title":"Minerva Surg"},{"key":"e_1_3_5_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.idnow.2023.104843"},{"key":"e_1_3_5_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehab724.2923"},{"key":"e_1_3_5_19_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0157234"},{"key":"e_1_3_5_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.microc.2023.108803"},{"key":"e_1_3_5_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-018-0147-4"},{"issue":"5","key":"e_1_3_5_22_2","first-page":"521","article-title":"CHINET surveillance of antimicrobial resistance among the bacterial isolates in 2021","volume":"22","author":"Hu FP","year":"2022","unstructured":"Hu FP, , Guo Y, , Zhu DM, et al. CHINET surveillance of antimicrobial resistance among the bacterial isolates in 2021. Chin. J. Infect. Chemother, 2022; 22(5):521\u2013530; doi: 10.16718\/j.1009-7708.2022.05.001","journal-title":"Chin. J. Infect. Chemother"},{"key":"e_1_3_5_23_2","doi-asserted-by":"publisher","DOI":"10.3969\/j.issn.1673-5501.2024.04.003"},{"key":"e_1_3_5_24_2","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics10050527"},{"key":"e_1_3_5_25_2","doi-asserted-by":"publisher","DOI":"10.3760\/cma.j.issn.1009-2587.2018.11.016"},{"key":"e_1_3_5_26_2","doi-asserted-by":"publisher","DOI":"10.33073\/pjm-2019-024"},{"key":"e_1_3_5_27_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12088-024-01228-3"},{"key":"e_1_3_5_28_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2023.1301744"},{"key":"e_1_3_5_29_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-05260-5"},{"key":"e_1_3_5_30_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2300220"}],"container-title":["Microbial Drug Resistance"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10766294261426734","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/10766294261426734","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10766294261426734","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T10:12:01Z","timestamp":1779185521000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/10766294261426734"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,6]]},"references-count":29,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5,1]]}},"alternative-id":["10.1177\/10766294261426734"],"URL":"https:\/\/doi.org\/10.1177\/10766294261426734","relation":{},"ISSN":["1076-6294","1931-8448"],"issn-type":[{"value":"1076-6294","type":"print"},{"value":"1931-8448","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,6]]}}}