{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T12:03:53Z","timestamp":1781093033237,"version":"3.54.1"},"reference-count":25,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T00:00:00Z","timestamp":1777248000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Microbial Drug Resistance"],"published-print":{"date-parts":[[2026,7,1]]},"abstract":"<jats:p>\n                    The drug-resistant profile of tuberculosis (TB) varies across geological regions. This study aimed to evaluate the association of\n                    <jats:italic toggle=\"yes\">katG<\/jats:italic>\n                    ,\n                    <jats:italic toggle=\"yes\">inhA,<\/jats:italic>\n                    and\n                    <jats:italic toggle=\"yes\">AhpC<\/jats:italic>\n                    mutations with isoniazid (INH) resistance of\n                    <jats:italic toggle=\"yes\">Mycobacterium tuberculosis<\/jats:italic>\n                    in pulmonary TB patients from Nanjing, China. Laboratory and genetic data of INH-resistant genes in TB patients living in Nanjing and hospitalized in the Department of Tuberculosis, the Second Hospital of Nanjing, from January 2019 to December 2021 were retrospectively analyzed. A total of 1,712 human\n                    <jats:italic toggle=\"yes\">M. tuberculosis<\/jats:italic>\n                    strains (1,308 INH-sensitive and 404 INH-resistant) were identified by phenotypic drug susceptibility testing (DST). Mutations were detected in\n                    <jats:italic toggle=\"yes\">katG315<\/jats:italic>\n                    , the\n                    <jats:italic toggle=\"yes\">inhA<\/jats:italic>\n                    promoter region, and the\n                    <jats:italic toggle=\"yes\">AhpC<\/jats:italic>\n                    promoter region. Among the 172 INH-resistant strains identified by phenotypic DST, 159 samples of gene mutations were detected. The mutation rate in\n                    <jats:italic toggle=\"yes\">katG315<\/jats:italic>\n                    in INH-resistant strains was significantly higher than those in the\n                    <jats:italic toggle=\"yes\">inhA<\/jats:italic>\n                    promoter region and\n                    <jats:italic toggle=\"yes\">AhpC<\/jats:italic>\n                    promoter region. The rate of INH resistance was higher in\n                    <jats:italic toggle=\"yes\">M. tuberculosis<\/jats:italic>\n                    strains with the\n                    <jats:italic toggle=\"yes\">katG315<\/jats:italic>\n                    mutation combined with the\n                    <jats:italic toggle=\"yes\">inhA<\/jats:italic>\n                    \/\n                    <jats:italic toggle=\"yes\">AhpC<\/jats:italic>\n                    promoter region mutations than in those with a single mutation in\n                    <jats:italic toggle=\"yes\">katG315<\/jats:italic>\n                    . The incidence of the\n                    <jats:italic toggle=\"yes\">katG315<\/jats:italic>\n                    mutation in multidrug-resistant TB patients and pre-extensively drug-resistant (pre XDR) TB patients was significantly higher than that in INH-resistant TB patients. The rate of\n                    <jats:italic toggle=\"yes\">katG315<\/jats:italic>\n                    mutation combined with the\n                    <jats:italic toggle=\"yes\">inhA<\/jats:italic>\n                    \/\n                    <jats:italic toggle=\"yes\">AhpC<\/jats:italic>\n                    promoter region mutation was higher in pre XDR-TB patients. The\n                    <jats:italic toggle=\"yes\">katG315<\/jats:italic>\n                    mutation, or its combination with\n                    <jats:italic toggle=\"yes\">inhA<\/jats:italic>\n                    \/\n                    <jats:italic toggle=\"yes\">AhpC<\/jats:italic>\n                    promoter region mutations, may be the main cause of INH resistance of\n                    <jats:italic toggle=\"yes\">M. tuberculosis<\/jats:italic>\n                    strains in TB patients from Nanjing, China.\n                  <\/jats:p>","DOI":"10.1177\/10766294261446052","type":"journal-article","created":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T10:24:34Z","timestamp":1777285474000},"page":"247-252","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Association of\n                    <i>katG<\/i>\n                    ,\n                    <i>inhA,<\/i>\n                    and\n                    <i>AhpC<\/i>\n                    Mutations with Isoniazid Resistance of\n                    <i>Mycobacterium tuberculosis<\/i>\n                    in Pulmonary Tuberculosis Patients from Nanjing, China"],"prefix":"10.1177","volume":"32","author":[{"given":"Yan","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Tuberculosis, The Second Hospital of Nanjing, Nanjing University of Chinese Medicine, Nanjing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Tuberculosis, The Second Hospital of Nanjing, Nanjing University of Chinese Medicine, Nanjing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Tuberculosis, The Second Hospital of Nanjing, Nanjing University of Chinese Medicine, Nanjing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yulan","family":"Niu","sequence":"additional","affiliation":[{"name":"Department of Tuberculosis, The Second Hospital of Nanjing, Nanjing University of Chinese Medicine, Nanjing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Kong","sequence":"additional","affiliation":[{"name":"Department of Tuberculosis, The Second Hospital of Nanjing, Nanjing University of Chinese Medicine, Nanjing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangrong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Tuberculosis, The Second Hospital of Nanjing, Nanjing University of Chinese Medicine, Nanjing, China."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,4,27]]},"reference":[{"key":"e_1_3_3_2_1","unstructured":"1.World Health Organization. Global tuberculosis report 2022. Geneva: WHO 2022."},{"key":"e_1_3_3_3_1","doi-asserted-by":"publisher","DOI":"10.4103\/lungindia.lungindia_204_19"},{"key":"e_1_3_3_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12866-018-1168-x"},{"key":"e_1_3_3_5_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.43.11.5477-5482.2005"},{"key":"e_1_3_3_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-46756-x"},{"issue":"7","key":"e_1_3_3_7_1","first-page":"983","article-title":"The guiding value of nicroarray technology in the treatment of multidrug-resistant tuberculosis","volume":"38","author":"Wang D","year":"2018","unstructured":"6.Wang D, , Liu Q, , Lu W, et al. The guiding value of nicroarray technology in the treatment of multidrug-resistant tuberculosis. Journal of Nanjing Medical University (Natural Sciences) 2018;38(7):983\u2013987.","journal-title":"Journal of Nanjing Medical University (Natural Sciences)"},{"key":"e_1_3_3_8_1","doi-asserted-by":"publisher","DOI":"10.1054\/tuld.1999.0231"},{"key":"e_1_3_3_9_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.46.5.1417-1424.2002"},{"key":"e_1_3_3_10_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00429-13"},{"key":"e_1_3_3_11_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.40.3.988-995.2002"},{"key":"e_1_3_3_12_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00561-08"},{"key":"e_1_3_3_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/femsre\/fuaa071"},{"key":"e_1_3_3_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/ardp.201600186"},{"key":"e_1_3_3_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2021.105242"},{"key":"e_1_3_3_16_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/257983"},{"key":"e_1_3_3_17_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01028-15"},{"issue":"3","key":"e_1_3_3_18_1","first-page":"344","article-title":"inhA promoter mutations: A gateway to extensively drug-resistant tuberculosis in South Africa","volume":"15","author":"M\u00fcller B","year":"2011","unstructured":"17.M\u00fcller B, , Streicher EM, , Hoek KG, et al. inhA promoter mutations: A gateway to extensively drug-resistant tuberculosis in South Africa? Int J Tuberc Lung Dis 2011;15(3):344\u2013351.","journal-title":"Int J Tuberc Lung Dis"},{"key":"e_1_3_3_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-021-04316-0"},{"key":"e_1_3_3_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.csbj.2021.04.034"},{"key":"e_1_3_3_21_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.2c01036"},{"key":"e_1_3_3_22_1","doi-asserted-by":"publisher","DOI":"10.1128\/mSphere.00111-21"},{"key":"e_1_3_3_23_1","doi-asserted-by":"publisher","DOI":"10.1080\/20477724.2021.1928870"},{"key":"e_1_3_3_24_1","doi-asserted-by":"publisher","DOI":"10.1099\/mgen.0.000542"},{"key":"e_1_3_3_25_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0166807"},{"key":"e_1_3_3_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41426-018-0184-0"}],"container-title":["Microbial Drug Resistance"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10766294261446052","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/10766294261446052","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/10766294261446052","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T11:19:18Z","timestamp":1781090358000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/10766294261446052"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,27]]},"references-count":25,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7,1]]}},"alternative-id":["10.1177\/10766294261446052"],"URL":"https:\/\/doi.org\/10.1177\/10766294261446052","relation":{},"ISSN":["1076-6294","1931-8448"],"issn-type":[{"value":"1076-6294","type":"print"},{"value":"1931-8448","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,27]]}}}