{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T21:59:25Z","timestamp":1781819965589,"version":"3.54.5"},"reference-count":31,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T00:00:00Z","timestamp":1778198400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Microbial Drug Resistance"],"published-print":{"date-parts":[[2026,8,1]]},"abstract":"<jats:p>\n                    Ventilator-associated pneumonia (VAP) caused by carbapenem-resistant\n                    <jats:italic toggle=\"yes\">Acinetobacter baumannii<\/jats:italic>\n                    (CRAB) poses a significant therapeutic challenge with high mortality rates. This study evaluated the clinical efficacy of high-dose ampicillin\u2013sulbactam combined with colistin compared to standard colistin-based regimens. This retrospective study was conducted on 83 patients with CRAB-VAP at Hanoi Medical University Hospital, Vietnam, from May 2024 to May 2025. Patients were divided into an intervention group (\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    = 33) treated with high-dose ampicillin\u2013sulbactam combined with colistin and a control group (\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    = 50) receiving other antibiotic regimens combined with colistin. Primary outcomes included 28-day mortality and total ventilation duration. The intervention group achieved significantly lower 28-day mortality (6.1% vs. 38.0%;\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    &lt; 0.001) and higher microbiological clearance rates by day 14 (93.9% vs. 30.0%;\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    &lt; 0.001). While early acute kidney injury was more frequent in the intervention group (66.7% vs. 24.0%), renal function outcomes were comparable by day 14. Multivariable analysis identified day-14 microbiological clearance as the strongest independent predictor of survival (hazard ratio [HR] = 13.03;\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    &lt; 0.001). High-dose ampicillin\u2013sulbactam combined with colistin significantly improves microbiological clearance and survival in patients with CRAB-VAP. Despite a higher incidence of transient nephrotoxicity, the regimen provides a substantial survival benefit.\n                  <\/jats:p>","DOI":"10.1177\/10766294261448634","type":"journal-article","created":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T09:49:23Z","timestamp":1778579363000},"page":"314-320","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical Outcomes of High-Dose Ampicillin\u2013Sulbactam Combined with Colistin in the Treatment of Ventilator-Associated Pneumonia Caused by Carbapenem-Resistant\n                    <i>Acinetobacter baumannii<\/i>"],"prefix":"10.1177","volume":"32","author":[{"given":"Bui Hai","family":"Hoang","sequence":"first","affiliation":[{"name":"Hanoi Meudical University Hospital, Hanoi, Vietnam."},{"name":"Hanoi Medical University, Hanoi, Vietnam."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linh Khanh","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Hanoi Medical University, Hanoi, Vietnam."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Son Thai","family":"Dinh","sequence":"additional","affiliation":[{"name":"Hanoi Medical University, Hanoi, Vietnam."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thi Huong Thao","family":"Bui","sequence":"additional","affiliation":[{"name":"Hanoi Medical University, Hanoi, Vietnam."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thanh Tat","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Hanoi Meudical University Hospital, Hanoi, Vietnam."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-2610-8420","authenticated-orcid":false,"given":"Tiep Khac","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Hanoi University of Pharmacy, Hanoi, Vietnam."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,5,8]]},"reference":[{"key":"e_1_3_2_2_1","doi-asserted-by":"publisher","DOI":"10.18683\/germs.2023.1408"},{"key":"e_1_3_2_3_1","doi-asserted-by":"publisher","DOI":"10.2147\/IDR.S332051"},{"key":"e_1_3_2_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1011520"},{"key":"e_1_3_2_5_1","doi-asserted-by":"publisher","DOI":"10.2147\/IDR.S145827"},{"key":"e_1_3_2_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2019.00092"},{"key":"e_1_3_2_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2023.1196774"},{"key":"e_1_3_2_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.crmicr.2024.100331"},{"key":"e_1_3_2_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics11010033"},{"key":"e_1_3_2_10_1","doi-asserted-by":"publisher","DOI":"10.4103\/ijccm.IJCCM_302_17"},{"key":"e_1_3_2_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics12030516"},{"key":"e_1_3_2_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-015-1865-4"},{"key":"e_1_3_2_13_1","doi-asserted-by":"publisher","DOI":"10.2147\/IDR.S332160"},{"key":"e_1_3_2_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics13050423"},{"key":"e_1_3_2_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms12071353"},{"key":"e_1_3_2_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jiph.2024.03.010"},{"key":"e_1_3_2_17_1","volume-title":"NHNS Patient Safefy Component Manual: Pneumonia (PNEU) and Ventilator- associated Pneumonia (VAP) Surveillance Protocol","author":"Centers for Disease Control and Prevention (CDC)","year":"2025","unstructured":"16.Centers for Disease Control and Prevention (CDC). NHNS Patient Safefy Component Manual: Pneumonia (PNEU) and Ventilator- associated Pneumonia (VAP) Surveillance Protocol. 2025 (document updated from 2023 version)."},{"key":"e_1_3_2_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciad428"},{"key":"e_1_3_2_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciae403"},{"key":"e_1_3_2_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/phar.2209"},{"key":"e_1_3_2_21_1","volume-title":"Guidelines for the use of priority-managed antibiotics","author":"Nguyen Hoang Anh","year":"2023","unstructured":"20.Nguyen Hoang Anh, , Dao Xuan Co. Guidelines for the use of priority-managed antibiotics. 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