{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T16:34:41Z","timestamp":1786120481783,"version":"build-2736575974"},"reference-count":54,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T00:00:00Z","timestamp":1780617600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Microbial Drug Resistance"],"published-print":{"date-parts":[[2026,9,1]]},"abstract":"<jats:p>\n                    Globally,\n                    <jats:italic toggle=\"yes\">Acinetobacter baumannii<\/jats:italic>\n                    has emerged as an important nosocomial pathogen and as highly resistant to clinically relevant antibiotics, namely, carbapenems. In this study, we aimed to determine the epidemiological profile and the imipenem (IPM) resistance rate of a clinical collection of\n                    <jats:italic toggle=\"yes\">A. baumannii<\/jats:italic>\n                    isolates. This study was carried out at the Central Laboratory of the Oran Regional University Military Hospital (H\u00f4pital militaire r\u00e9gional universitaire d\u2019Oran) over a period of 7 years (January 2010\u2013December 2016). The frequency of\n                    <jats:italic toggle=\"yes\">A. baumannii<\/jats:italic>\n                    isolates was not constant over the 7 years; however, an increasing trend was observed. Among the 168 isolates, the majority was isolated from male patients (\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    = 131, 78%). Patients in the intensive care unit had a higher risk of developing\n                    <jats:italic toggle=\"yes\">A. baumannii<\/jats:italic>\n                    infection (76%) compared to other hospital services, and protected distal pulmonary samples were the main site of isolation of\n                    <jats:italic toggle=\"yes\">A. baumannii<\/jats:italic>\n                    isolates (34%). Among the collected isolates, 106 were IPM resistant and exhibited multidrug phenotypes. These results confirm the multidrug-resistant nature of\n                    <jats:italic toggle=\"yes\">A. baumannii<\/jats:italic>\n                    and its nosocomial behavior. The emergence of this bacterial species represents a serious therapeutic and epidemiological problem, hence the need for the establishment of a system for monitoring the microbial environment of the hospital and the strict application of hygiene measures.\n                  <\/jats:p>","DOI":"10.1177\/10766294261457994","type":"journal-article","created":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T16:28:36Z","timestamp":1780676916000},"page":"340-347","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Epidemiology and Imipenem Resistance in\n                    <i>Acinetobacter baumannii<\/i>\n                    Isolates at the Regional Military University Hospital of Oran (HMRUO), Algeria"],"prefix":"10.1177","volume":"32","author":[{"given":"Noura","family":"Benhamouche","sequence":"first","affiliation":[{"name":"Department of Applied Molecular Genetics, Faculty of Natural and Life Sciences, University of Sciences and Technology Mohamed Boudiaf (USTO-MB), BP1505, Bir El Djir, Oran 31000, Algeria."},{"name":"Laboratory Toxicology Environment and Health (LATES), Department of applied molecular genetics, University of Science and Technology of Oran Mohamed Boudiaf (USTO-MB), BP1505, Bir El Djir, Oran 31000, Algeria.\u00a0"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed","family":"Harir","sequence":"additional","affiliation":[{"name":"Department of Applied Molecular Genetics, Faculty of Natural and Life Sciences, University of Sciences and Technology Mohamed Boudiaf (USTO-MB), BP1505, Bir El Djir, Oran 31000, Algeria."},{"name":"Biology of Microorganisms and Biotechnology Laboratory, University of Oran 1, Ahmed Ben Bella, El Mnaouer BP1524, Oran 31000, Algeria.\u00a0"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bouabdellah","family":"Rahmani","sequence":"additional","affiliation":[{"name":"Faculty of Electrical Engineering, Department of Electronics, University of Science and Technology of Oran Mohamed-Boudiaf (USTO-MB), BP1505, Bir El Djir, Oran 31000, Algeria."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lahcen","family":"Benmahdi","sequence":"additional","affiliation":[{"name":"Central Laboratory of the HMRU of Oran, Faculty of Medicine, University of Oran 1 Ahmed Ben Bella, El Mnaouer BP1524, Oran 31000, Algeria."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9673-193X","authenticated-orcid":false,"given":"Mohamed Salah","family":"Abbassi","sequence":"additional","affiliation":[{"name":"Faculty of Medicine of Tunis, Laboratory of Antibiotic Resistance LR99ES09, University of Tunis El Manar, 1006 Tunis, Tunisia."},{"name":"Tunisian institute of veterinary research, University of Tunis El Manar, 1006 Tunis, Tunisia."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,6,5]]},"reference":[{"key":"e_1_3_2_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sjbs.2016.02.009"},{"key":"e_1_3_2_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/21505594.2023.2289769"},{"key":"e_1_3_2_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.micres.2021.126722"},{"key":"e_1_3_2_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro.2017.148"},{"key":"e_1_3_2_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21155498"},{"key":"e_1_3_2_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro1789"},{"key":"e_1_3_2_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/21505594.2016.1150405"},{"key":"e_1_3_2_9_1","doi-asserted-by":"publisher","DOI":"10.2147\/IDR.S169894"},{"key":"e_1_3_2_10_1","unstructured":"9.WHO. Prioritization of pathogens to guide discovery research and development of new antibiotics for drug-resistant bacterial infections including tuberculosis. Sept 4 2017. 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Periodic phenotypic profile analysis of Acinetobacter baumannii drug resistance characteristics showing the emergence of PDR. 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Acinetobacter baumanii: \u00c9pid\u00e9miologie et r\u00e9sistance aux antibiotiques. Th\u00e8se de M\u00e9decine. MARRAKECH (Maroc) 2019. N\u00b0102: pp. 13\u201317."},{"key":"e_1_3_2_33_1","doi-asserted-by":"publisher","DOI":"10.11604\/pamj.2019.33.146.17220"},{"key":"e_1_3_2_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajic.2017.12.014"},{"key":"e_1_3_2_35_1","unstructured":"34.Soukaina W. Epid\u00e9miologie et r\u00e9sistance aux antibiotiques des isolats cliniques d\u2019Acinetobacter baumannii \u00e0 l\u2019h\u00f4pital militaire moulay Ismail\u2014Mekn\u00e9s. Th\u00e8se de Medecine. Sidi mohammed Ben abdellah (Royaume de Maroc) 2017. 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