{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T00:06:15Z","timestamp":1789689975643,"version":"4.0.1"},"reference-count":50,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T00:00:00Z","timestamp":1781654400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Microbial Drug Resistance"],"published-print":{"date-parts":[[2026,11,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>\n                      To characterize the clinical and genomic features of vancomycin-resistant\n                      <jats:italic toggle=\"yes\">enterococci<\/jats:italic>\n                      (VRE) in a tertiary hospital in Huizhou and identify risk factors to inform local infection control.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      A retrospective study included 58 VRE and 25 vancomycin-susceptible\n                      <jats:italic toggle=\"yes\">Enterococci<\/jats:italic>\n                      (VSE) strains (August 2023\u2013May 2025). Clinical data and antimicrobial susceptibility were analyzed; whole-genome sequencing (WGS) was performed on 54 VRE strains.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Midstream urine was the primary VRE-positive specimen. ICU admission, polyantibiotic use (\u22653 agents), and urinary catheterization were key risk factors for VRE. All VRE isolates were\n                      <jats:italic toggle=\"yes\">Enterococcus faecium<\/jats:italic>\n                      and showed a predominantly clonal population structure, dominated by CC17\/ST80 (68.8%) and CC2\/ST106 (64.6%) under the two multilocus sequence typing schemes; five novel STs were ultimately identified in the latter scheme. VRE was universally resistant to ampicillin, with high resistance to penicillin, levofloxacin, and teicoplanin, while linezolid and tigecycline remained effective. Genotypically, 94.8% carried\n                      <jats:italic toggle=\"yes\">vanA<\/jats:italic>\n                      , 100% carried virulence gene\n                      <jats:italic toggle=\"yes\">esp<\/jats:italic>\n                      , and aminoglycoside and macrolide resistance genes were prevalent. A unique VRE strain (VRE48) showed resistance without canonical\n                      <jats:italic toggle=\"yes\">van<\/jats:italic>\n                      genes, harboring a\n                      <jats:italic toggle=\"yes\">Ddl<\/jats:italic>\n                      Ser210Tyr mutation.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10766294261460629","type":"journal-article","created":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T13:32:43Z","timestamp":1781703163000},"page":"461-471","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical Characteristics and Genomic Analysis of Vancomycin-Resistant\n                    <i>Enterococcus faecium<\/i>\n                    in a Tertiary Hospital in Huizhou"],"prefix":"10.1177","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-8616-407X","authenticated-orcid":false,"given":"Yaomao","family":"Yan","sequence":"first","affiliation":[{"name":"Guangdong Medical University, Zhanjiang, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuying","family":"Yao","sequence":"additional","affiliation":[{"name":"Guangdong Medical University, Zhanjiang, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyun","family":"Liu","sequence":"additional","affiliation":[{"name":"Huizhou Central People\u2019s Hospital, Huizhou, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueyan","family":"Liang","sequence":"additional","affiliation":[{"name":"Huizhou Central People\u2019s Hospital, Huizhou, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zuguo","family":"Zhao","sequence":"additional","affiliation":[{"name":"Guangdong Medical University, Zhanjiang, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianjin","family":"Wu","sequence":"additional","affiliation":[{"name":"Guangdong Medical University, Zhanjiang, China."},{"name":"Huizhou Central People\u2019s Hospital, Huizhou, 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