{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T13:50:33Z","timestamp":1793022633848,"version":"4.5.0"},"reference-count":34,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T00:00:00Z","timestamp":1783641600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Shaanxi Provincial Key Research and Development Project","award":["2024SF-YBXM-110"],"award-info":[{"award-number":["2024SF-YBXM-110"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Microbial Drug Resistance"],"published-print":{"date-parts":[[2026,12,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>\n                      The prevalence of carbapenem-resistant\n                      <jats:italic toggle=\"yes\">Acinetobacter baumannii<\/jats:italic>\n                      (CRAb) has been increasing globally. This study aimed to investigate the risk factors, resistance gene profiles, and molecular epidemiology of CRAb bloodstream infections (BSIs) among patients in Xi\u2019an, China, to provide evidence for clinical prevention and targeted treatment.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      We conducted a retrospective study of 139 patients with\n                      <jats:italic toggle=\"yes\">A. baumannii<\/jats:italic>\n                      BSIs. Patients were categorized into a CRAb group (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 84) and a carbapenem-susceptible\n                      <jats:italic toggle=\"yes\">A. baumannii<\/jats:italic>\n                      (CSAb) group (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 55). Independent risk factors were identified via multivariate logistic regression analysis. Carbapenemase resistance genes were detected using polymerase chain reaction (PCR), and CRAb isolates were molecularly typed by multilocus sequence typing (MLST).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Multivariate logistic regression analysis identified the following as independent risk factors for CRAb BSIs: inappropriate empirical antimicrobial therapy (\n                      <jats:italic toggle=\"yes\">OR<\/jats:italic>\n                      = 8.620; 95% CI: 2.078\u201335.751), deep venous catheterization (\n                      <jats:italic toggle=\"yes\">OR<\/jats:italic>\n                      = 12.625; 95% CI: 2.263\u201370.429), prolonged hospitalization before the onset of BSIs (\n                      <jats:italic toggle=\"yes\">OR<\/jats:italic>\n                      = 1.467; 95% CI: 1.123\u20131.915), and ICU admission (\n                      <jats:italic toggle=\"yes\">OR<\/jats:italic>\n                      = 4.981; 95% CI: 1.898\u201313.065). Antimicrobial susceptibility testing showed that CRAb isolates were multidrug-resistant, exhibiting resistance rates exceeding 70% to most common clinical antibiotics, with the exception of tigecycline (5.95% resistance) and colistin (27.38% resistance). All 84 CRAb isolates carried both\n                      <jats:italic toggle=\"yes\">bla<\/jats:italic>\n                      OXA-51-like and\n                      <jats:italic toggle=\"yes\">bla<\/jats:italic>\n                      OXA-23-like genes, while other carbapenemase genes were not detected. MLST identified 7 sequence types (STs), with ST540 (45.24%, 38\/84) being the dominant clone. eBURST analysis indicated that the major STs (ST195, ST208, etc.) belonged to the same clonal complex.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Inappropriate empirical antimicrobial therapy, deep venous catheterization, prolonged hospitalization before the onset of BSIs and ICU admission are independent risk factors for CRAb BSIs. The prevalent strains produce OXA-23-like carbapenemase, and molecular typing indicates that the ST540 clone and its related clonal complex are predominant, suggesting potential nosocomial clonal spread.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10766294261467800","type":"journal-article","created":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T09:51:40Z","timestamp":1783677100000},"page":"575-583","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Analysis of Risk Factors and Resistance Genes for Carbapenem-Resistant\n                    <i>Acinetobacter baumannii<\/i>\n                    Bloodstream Infections: A Retrospective Study"],"prefix":"10.1177","volume":"32","author":[{"given":"Jiahao","family":"Guan","sequence":"first","affiliation":[{"name":"Department of Clinical Laboratory, Shaanxi Provincial People\u2019s Hospital, Xi\u2019an, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yajuan","family":"Ren","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, Shaanxi Provincial People\u2019s Hospital, Xi\u2019an, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojun","family":"Dang","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Shaanxi Provincial People\u2019s Hospital, Xi\u2019an, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zifan","family":"Lu","sequence":"additional","affiliation":[{"name":"Translational medicine Center of Shaanxi Provincial People\u2019s Hospital; Shaanxi Province Research Center of Cell Immunological Engineering and Technology, Shaanxi Provincial People\u2019s Hospital, Xi\u2019an, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-2681-3171","authenticated-orcid":false,"given":"Lixia","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Shaanxi Provincial People\u2019s Hospital, Xi\u2019an, China."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,7,10]]},"reference":[{"key":"e_1_3_3_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2017.00055"},{"key":"e_1_3_3_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.micpath.2025.107605"},{"key":"e_1_3_3_4_1","doi-asserted-by":"publisher","DOI":"10.1128\/mSphere.00310-16"},{"key":"e_1_3_3_5_1","doi-asserted-by":"publisher","DOI":"10.1128\/mbio.02260-23"},{"key":"e_1_3_3_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/jambio\/lxaf102"},{"key":"e_1_3_3_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/22221751.2019.1698273"},{"key":"e_1_3_3_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-021-06690-6"},{"key":"e_1_3_3_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciad556"},{"key":"e_1_3_3_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-024-02104-6"},{"key":"e_1_3_3_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/jacamr\/dlaf134"},{"key":"e_1_3_3_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(23)00203-7"},{"key":"e_1_3_3_13_1","doi-asserted-by":"publisher","DOI":"10.1590\/0037-8682-0529-2021"},{"key":"e_1_3_3_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro3093"},{"key":"e_1_3_3_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2016.01717"},{"key":"e_1_3_3_16_1","volume-title":"Performance Standards for Antimicrobial Susceptibility Testing, M100","author":"CLSI","year":"2024","unstructured":"15.CLSI. 2024. 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