{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:34:48Z","timestamp":1792787688270,"version":"4.5.0"},"reference-count":45,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T00:00:00Z","timestamp":1788393600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Philippine Council for Health Research and Development","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}],"id":[{"id":"https:\/\/ror.org\/04rpdbq72","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Microbial Drug Resistance"],"abstract":"<jats:title\/>\n                  <jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>This study describes the clinical profiles, phenotypic and genotypic resistance mechanisms, and outcomes of patients with carbapenem-resistant infections (CRIs) using a registry.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Hospitalized adults with CRIs in two tertiary institutions were included in this prospective study from January 1, 2023, to December 31, 2025.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      A total of 411 patients were included. Half were male (207\/411, 50.4%), with median age 59 (range 19\u201398) years. Hypertension (251, 65.5%), diabetes mellitus (150, 39.2%), and cancer (133, 34.7%) were frequent comorbidities. Of 518 CRIs, half were respiratory (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 284\/518, 49.8%) from ventilator-associated pneumonia (VAP) (163\/284, 57.4%) or hospital-acquired pneumonia (HAP) (117\/284, 41.2%). Carbapanem-resistant Enterobacterales (CRE) (301\/518, 58.1%) and carbapenem-resistant\n                      <jats:italic toggle=\"yes\">Acinetobacter baumannii<\/jats:italic>\n                      (CRAB) (154\/518, 29.7%) were the most common pathogens. The majority expressed efflux pumps (388\/411, 94.4%). Class B metallo \u03b2-lactamase (\n                      <jats:italic toggle=\"yes\">bla<\/jats:italic>\n                      <jats:sub>NDM<\/jats:sub>\n                      ) for CRE and Class D\n                      <jats:italic toggle=\"yes\">bla<\/jats:italic>\n                      <jats:sub>OXA-51-like<\/jats:sub>\n                      for CRAB were frequent. Overall mortality at the end of hospital stay was 46%.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>\n                      Most CRIs in this cohort were CRE and CRAB from HAP\/VAP. Organisms possessed multiple mechanisms of resistance, with phenotypic expression of efflux pumps and\n                      <jats:italic toggle=\"yes\">bla<\/jats:italic>\n                      <jats:sub>NDM<\/jats:sub>\n                      and\n                      <jats:italic toggle=\"yes\">bla<\/jats:italic>\n                      <jats:sub>OXA-51-like<\/jats:sub>\n                      predominating. High mortality rate was independent of the mechanism of resistance. Novel antimicrobials directed against these specific resistance mechanisms are urgently needed. This registry can be expanded to provide a real-world view of clinical practices.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/10766294261485031","type":"journal-article","created":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T18:59:53Z","timestamp":1788461993000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Using an Online Registry of Carbapenemase-Producing Gram-Negative Organisms to Report the Clinical Profile, Outcomes, and Phenotypic and Genotypic Resistances in Two Tertiary Level Hospitals in the Philippines (ORiGiN Study)"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5183-8239","authenticated-orcid":false,"given":"Cybele Lara R.","family":"Abad","sequence":"first","affiliation":[{"name":"Department of Medicine, Division of Infectious Diseases, Philippine General Hospital, University of the Philippines Manila, Manila, Philippines."},{"name":"Department of Medicine, Section of Infectious Diseases, The Medical City, Pasig, Philippines."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian Ronald A.","family":"Espino","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Infectious Diseases, Philippine General Hospital, University of the Philippines Manila, Manila, Philippines."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veil Maria T.","family":"Castro","sequence":"additional","affiliation":[{"name":"Clinical and Translational Research Institute, The Medical City, Pasig City, Philippines."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrei Dominique","family":"Montero","sequence":"additional","affiliation":[{"name":"Clinical and Translational Research Institute, The Medical City, Pasig City, Philippines."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark B.","family":"Carascal","sequence":"additional","affiliation":[{"name":"Clinical and Translational Research Institute, The Medical City, Pasig City, Philippines."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanaia Esthelle Joy","family":"Daguit","sequence":"additional","affiliation":[{"name":"Clinical and Translational Research Institute, The Medical City, Pasig City, Philippines."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eariel","family":"Francisco","sequence":"additional","affiliation":[{"name":"Clinical and Translational Research Institute, The Medical City, Pasig City, Philippines."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5569-9945","authenticated-orcid":false,"given":"Lawrence S.","family":"Macalalad","sequence":"additional","affiliation":[{"name":"Clinical and Translational Research Institute, The Medical City, Pasig City, Philippines."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0511-0407","authenticated-orcid":false,"given":"Kim L.","family":"Cochon","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology, College of Medicine, University of the Philippines Manila, Manila, Philippines."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danice Faith","family":"Alombro","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Infectious Diseases, Philippine General Hospital, University of the Philippines Manila, Manila, Philippines."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjo P.","family":"Ato","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Infectious Diseases, Philippine General Hospital, University of the Philippines Manila, Manila, 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