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Utilizing longitudinal data (\n                    <jats:italic toggle=\"yes\">N<\/jats:italic>\n                    = 247), the current study examined maternal and offspring history of childhood maltreatment (CM) as predictors of offspring cortisol\/DHEA ratios, and, in exploratory analyses, extended this longitudinally to offspring depressive symptoms in young adulthood. Youth (ages 8\u201313 years) initially attended a research camp, then were followed up approximately eight years later (ages 18\u201322 years). Maternal history of CM significantly predicted their offspring\u2019s childhood cortisol\/DHEA ratio over and above the effects of the offspring\u2019s history of CM. Offspring CM was not a significant predictor of the ratio. The cortisol\/DHEA ratio did not mediate the relationship between maternal history of CM and offspring emerging adulthood depression. Results highlight an intergenerational cascade of CM and negative outcomes and support inclusion of maternal experiences in screening for at-risk youth.\n                  <\/jats:p>","DOI":"10.1177\/10775595251317449","type":"journal-article","created":{"date-parts":[[2025,1,29]],"date-time":"2025-01-29T13:52:35Z","timestamp":1738158755000},"page":"638-648","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Maternal History of Child Maltreatment Predicts Dysregulated Offspring Stress Response System Functioning"],"prefix":"10.1177","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0969-207X","authenticated-orcid":false,"given":"Rachel Y.","family":"Levin","sequence":"first","affiliation":[{"name":"University of Rochester"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin","family":"Russotti","sequence":"additional","affiliation":[{"name":"University of Rochester"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheree L.","family":"Toth","sequence":"additional","affiliation":[{"name":"University of Rochester"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dante","family":"Cicchetti","sequence":"additional","affiliation":[{"name":"University of Rochester"},{"name":"University of Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0087-0263","authenticated-orcid":false,"given":"Elizabeth D.","family":"Handley","sequence":"additional","affiliation":[{"name":"University of Rochester"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,1,29]]},"reference":[{"key":"e_1_3_3_2_1","doi-asserted-by":"publisher","DOI":"10.1037\/a0024892"},{"key":"e_1_3_3_3_1","volume-title":"Diagnostic and statistical manual of mental disorders","author":"American Psychiatric Association","year":"1994","unstructured":"American Psychiatric Association. 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