{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T16:41:32Z","timestamp":1781196092054,"version":"3.54.1"},"reference-count":100,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2009,1,26]],"date-time":"2009-01-26T00:00:00Z","timestamp":1232928000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Oncol Pharm Pract"],"published-print":{"date-parts":[[2009,9]]},"abstract":"<jats:p>Purpose. To provide a comprehensive literature review of chemotherapy-induced nail toxicity, including clinical presentation, implicated drugs and approaches for prevention and management.<\/jats:p>\n                  <jats:p>Data sources. A search of MEDLINE and EMBASE (1966\u20142008) databases was conducted using the terms (and variations of the terms) antineoplastic agents, nails, nail toxicity, onycholysis, and paronychia. Bibliographies from selected articles were reviewed for appropriate references.<\/jats:p>\n                  <jats:p>Data extraction. The retrieved literature was reviewed to include all articles relevant to the clinical presentation, diagnosis, incidence, prevention, and treatment of chemotherapy-induced nail toxicity.<\/jats:p>\n                  <jats:p>Data synthesis. Nail toxicity is a relatively uncommon adverse effect linked to a number of chemotherapeutic agents. Clinical presentation varies, depending on which nail structure is affected and the severity of the insult. Nail changes may involve all or some nails. Toxicity may be asymptomatic and limited to cosmetic concerns, however, more severe effects, involving pain and discomfort can occur. Taxanes and anthracyclines are the antineoplastic drug groups most commonly implicated. It is suggested that the administration schedule may influence the incidence of nail abnormalities, for example reported cases linked to the weekly administration of paclitaxel.<\/jats:p>\n                  <jats:p>Before instituting chemotherapy, patients should be educated regarding potential nail toxicities and strategies for prevention implemented. Management includes appropriate nail cutting, avoiding potential irritants, topical, or oral antimicrobials, and possibly cessation or dose reduction of the offending agent. Cryotherapy, through the application of frozen gloves or socks, has been beneficial in reducing docetaxel-induced nail toxicity and may be effective for other drugs. J Oncol Pharm Practice (2009) 15: 143\u2014155.<\/jats:p>","DOI":"10.1177\/1078155208100450","type":"journal-article","created":{"date-parts":[[2009,1,26]],"date-time":"2009-01-26T20:12:48Z","timestamp":1233000768000},"page":"143-155","source":"Crossref","is-referenced-by-count":76,"title":["Nail Toxicity Induced by Cancer Chemotherapy"],"prefix":"10.1177","volume":"15","author":[{"given":"Peter","family":"Gilbar","sequence":"first","affiliation":[{"name":"Department of Pharmacy, Toowoomba Health Services, PMB 2, Toowoomba, Australia,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice","family":"Hain","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Toowoomba Health Services, PMB 2, Toowoomba, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veta-Marie","family":"Peereboom","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Toowoomba Health Services, PMB 2, Toowoomba, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2009,1,26]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1016\/j.det.2006.03.004"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.2165\/00002018-199921030-00004"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1016\/j.det.2007.01.006"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1016\/j.det.2007.08.003"},{"key":"atypb5","doi-asserted-by":"crossref","unstructured":"Tosti A, Iorizzo M, Piraccini BM, Starace M. The nail in systemic diseases. Dermatol Clin 2006; 24: 341-7. 6 Piraccini BM, Iorizzo M, Tosti A. Drug-induced nail abnormalities. Am J Clin Dermatol 2003; 4: 31-7.","DOI":"10.1016\/j.det.2006.03.005"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1016\/j.det.2006.03.007"},{"key":"atypb7","first-page":"334","volume":"86","author":"Vassallo C.","year":"2001","journal-title":"Haematologica"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2004.00775.x"},{"key":"atypb9","volume-title":"Common terminology criteria for adverse events v3.0","author":"Cancer Therapy Evaluation Program.","year":"2006"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1136\/pgmj.2006.045229"},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-95-3-288"},{"key":"atypb12","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1984.01650430153030"},{"key":"atypb13","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(99)70488-3"},{"key":"atypb14","first-page":"520","volume":"145","author":"Chen GY","year":"2001","journal-title":"Br J Dermatol"},{"key":"atypb15","first-page":"234","volume":"72","author":"Maino KL","year":"2003","journal-title":"Cutis"},{"key":"atypb16","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djg034"},{"key":"atypb17","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2006.09.013"},{"key":"atypb18","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2001.04226.x"},{"key":"atypb19","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2002.124621"},{"key":"atypb20","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2003.04.169"},{"key":"atypb21","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.5809.352-b"},{"key":"atypb22","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(75)90916-2"},{"key":"atypb23","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1978.tb03587.x"},{"key":"atypb24","first-page":"35","volume":"22","author":"Adam BA","year":"1981","journal-title":"Sing Med J"},{"key":"atypb25","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2002.03449.x"},{"key":"atypb26","first-page":"14","volume":"9","author":"Dave S.","year":"2003","journal-title":"Dermatol Online J"},{"key":"atypb27","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-89-4-516"},{"key":"atypb28","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.1997.tb00222.x"},{"key":"atypb29","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdg050"},{"key":"atypb30","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1997.03890470146034"},{"key":"atypb31","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.134.9.1167"},{"key":"atypb32","doi-asserted-by":"publisher","DOI":"10.1023\/A:1008218824342"},{"key":"atypb33","doi-asserted-by":"publisher","DOI":"10.1159\/000018132"},{"key":"atypb34","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2000.03692.x"},{"key":"atypb35","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2002.46824.x"},{"key":"atypb36","first-page":"15","volume":"9","author":"Abou Mourad Y.","year":"2003","journal-title":"Dermatol Online J"},{"key":"atypb37","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2003.05272.x"},{"key":"atypb38","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMicm040187"},{"key":"atypb39","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2006.02731.x"},{"key":"atypb40","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)04210-0"},{"key":"atypb41","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-0960.2002.00616.x"},{"key":"atypb42","doi-asserted-by":"publisher","DOI":"10.1023\/A:1016002329546"},{"key":"atypb43","doi-asserted-by":"publisher","DOI":"10.3349\/ymj.2007.48.1.124"},{"key":"atypb44","doi-asserted-by":"publisher","DOI":"10.1093\/jjco\/hym042"},{"key":"atypb45","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-007-0232-0"},{"key":"atypb46","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1995.13.12.2886"},{"key":"atypb47","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2005.02.016"},{"key":"atypb48","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(75)92341-7"},{"key":"atypb49","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1990.01670330124031"},{"key":"atypb50","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdj015"},{"key":"atypb51","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1006\/gyno.1995.1170","volume":"57","author":"Obermair A.","year":"1995","journal-title":"Gynecol Oncol"},{"key":"atypb52","doi-asserted-by":"publisher","DOI":"10.1159\/000070954"},{"key":"atypb53","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2004.02.168"},{"key":"atypb54","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(08)80119-3"},{"key":"atypb55","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(96)90353-9"},{"key":"atypb56","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4362.1997.tb04194.x"},{"key":"atypb57","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(99)70379-8"},{"key":"atypb58","first-page":"748","volume":"83","author":"Las Heras G.","year":"1998","journal-title":"Haematologica"},{"key":"atypb59","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2001.113471"},{"key":"atypb60","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2002.120910"},{"key":"atypb61","doi-asserted-by":"publisher","DOI":"10.1046\/j.0307-6938.2001.00947.x"},{"key":"atypb62","doi-asserted-by":"publisher","DOI":"10.1067\/S0190-9622(03)00427-4"},{"key":"atypb63","doi-asserted-by":"publisher","DOI":"10.1111\/j.0736-8046.2004.21207.x"},{"key":"atypb64","doi-asserted-by":"publisher","DOI":"10.1111\/j.0736-8046.2004.21603.x"},{"key":"atypb65","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2006.02709.x"},{"key":"atypb66","first-page":"203","volume":"59","author":"Borecky DJ","year":"1997","journal-title":"Cutis"},{"key":"atypb67","first-page":"333","volume":"86","author":"Deliliers GL","year":"2001","journal-title":"Haematologica"},{"key":"atypb68","doi-asserted-by":"publisher","DOI":"10.4103\/0378-6323.19727"},{"key":"atypb69","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2006.07262.x"},{"key":"atypb70","first-page":"3531","volume":"25","author":"Alimonti A.","year":"2005","journal-title":"Anticancer Res"},{"key":"atypb71","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1983.01650310085020"},{"key":"atypb72","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1987.01660320030005"},{"key":"atypb73","first-page":"276","volume":"197","author":"Malka N.","year":"1998","journal-title":"Dermatol"},{"key":"atypb74","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(88)90306-6"},{"key":"atypb75","doi-asserted-by":"publisher","DOI":"10.1016\/0959-8049(92)90419-3"},{"key":"atypb76","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.1995.tb01377.x"},{"key":"atypb77","doi-asserted-by":"publisher","DOI":"10.1016\/0959-8049(95)00570-6"},{"key":"atypb78","first-page":"490","volume":"4","author":"Freiman A.","year":"2005","journal-title":"J Drugs Dermatol"},{"key":"atypb79","doi-asserted-by":"publisher","DOI":"10.1007\/BF00873811"},{"key":"atypb80","doi-asserted-by":"publisher","DOI":"10.1080\/014436102762062439"},{"key":"atypb81","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdg419"},{"key":"atypb82","doi-asserted-by":"publisher","DOI":"10.1023\/A:1008434626876"},{"key":"atypb83","doi-asserted-by":"publisher","DOI":"10.1345\/aph.18307"},{"key":"atypb84","first-page":"146","volume":"10","author":"Almagro M.","year":"2000","journal-title":"Eur J Dermatol"},{"key":"atypb85","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(20000515)88:10<2367::AID-CNCR22>3.0.CO;2-#"},{"key":"atypb86","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2002.99.147"},{"key":"atypb87","first-page":"16","volume":"9","author":"Albares MP","year":"2003","journal-title":"Dermatot Online J"},{"key":"atypb88","first-page":"229","volume":"71","author":"Mackay-Wiggan J.","year":"2003","journal-title":"Cutis"},{"key":"atypb89","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-3083.2003.00774.x"},{"key":"atypb90","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-9740.2007.05720.x"},{"key":"atypb91","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-143-4-200508160-00021"},{"key":"atypb92","doi-asserted-by":"publisher","DOI":"10.1080\/00015550310007715"},{"key":"atypb93","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.2004.tb00636.x"},{"key":"atypb94","doi-asserted-by":"publisher","DOI":"10.1097\/00007611-199704000-00006"},{"key":"atypb95","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-3083.2002.00424.x"},{"key":"atypb96","doi-asserted-by":"crossref","first-page":"10","DOI":"10.5070\/D321M795KV","volume":"12","author":"Dasanu CA","year":"2006","journal-title":"Dermatol Online J"},{"key":"atypb97","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2006.01887.x"},{"key":"atypb98","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-4362.2003.01727.x"},{"key":"atypb99","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.15.651"},{"key":"atypb100","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.23333"}],"container-title":["Journal of Oncology Pharmacy Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1078155208100450","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1078155208100450","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T02:13:28Z","timestamp":1777688008000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1078155208100450"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,1,26]]},"references-count":100,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2009,9]]}},"alternative-id":["10.1177\/1078155208100450"],"URL":"https:\/\/doi.org\/10.1177\/1078155208100450","relation":{},"ISSN":["1078-1552","1477-092X"],"issn-type":[{"value":"1078-1552","type":"print"},{"value":"1477-092X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,1,26]]}}}