{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T22:36:13Z","timestamp":1777934173693,"version":"3.51.4"},"reference-count":22,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2009,10,15]],"date-time":"2009-10-15T00:00:00Z","timestamp":1255564800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Oncol Pharm Pract"],"published-print":{"date-parts":[[2011,6]]},"abstract":"<jats:p>Purpose. To describe the successful use of glucar- pidase (carboxypeptidase G2) in the treatment of high-dose methotrexate-induced nephrotoxicity in a patient with osteosarcoma.<\/jats:p>\n                  <jats:p>Summary. A 12-year-old female patient who had been diagnosed with low-grade right mandibular osteosarcoma was started on a protocol of cisplatin plus doxorubicin alternating with high-dose metho- trexate. Following her first dose of methotrexte, she developed acute renal failure and higher than expected 24h methotrexate level of 478\u03bcM\/L. High-dose leucovorin rescue was started with vigorous hydra- tion and urine alkalinization together with two sessions of hemodialysis. Because her methotrexate level was persistently high, the investigational drug glucarpidase was administered. Methotrexate leveldropped from 65 to 16.3 \u03bcM\/L after a single dose of glucarpidase measured by fluorescence polarization immunoassay. Leucovorin and urine alkalinization were continued until day 17 when the patient\u2019s kidney function normalized and methotrexate level reached 0.05 \u03bcM\/L. The patient tolerated glucarpidase well without any significant adverse events.<\/jats:p>\n                  <jats:p>Conclusion. Glucarpidase is a safe and effective agent in the management of high-dose methotrexate-induced nephrotoxicity and delayed methotrexate elimination. J Oncol Pharm Practice (2011) 17: 136\u2014140.<\/jats:p>","DOI":"10.1177\/1078155209348720","type":"journal-article","created":{"date-parts":[[2009,10,15]],"date-time":"2009-10-15T20:34:29Z","timestamp":1255638869000},"page":"136-140","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":10,"title":["Glucarpidase rescue in a patient with high-dose methotrexate-induced nephrotoxicity"],"prefix":"10.1177","volume":"17","author":[{"given":"Haitham W","family":"Tuffaha","sequence":"first","affiliation":[{"name":"King Hussein Cancer Center, P.O. Box 1269 Aljubeiha, Amman, 11941 Jordan,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suha","family":"Al Omar","sequence":"additional","affiliation":[{"name":"King Hussein Cancer Center, P.O. Box 1269 Aljubeiha, Amman, 11941 Jordan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2009,10,15]]},"reference":[{"issue":"1","key":"atypb1","first-page":"CD006325","volume":"21","author":"Van Dalen EC","year":"2009","journal-title":"Cochrane Database Syst Rev."},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminoncol.2004.07.011"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1016\/S0305-7372(77)80007-8"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1007\/s10637-005-4541-1"},{"key":"atypb5","unstructured":"Kummar S., Noronha V., Chu E. Antimetabolites. In: DeVita VT, Hellman S, Rosenberg SA. eds. Cancer principles and practice of oncology, seventh edn. Philadelphia: Lippincott Williams & Wilkins, 2005: 358-374."},{"key":"atypb6","unstructured":"Messmann R., Allegra C. Antifolates. In: Chabner B, Longo D. eds. Cancer chemotherapy and biotherapy. 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