{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T22:36:32Z","timestamp":1777934192047,"version":"3.51.4"},"reference-count":42,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2011,3,21]],"date-time":"2011-03-21T00:00:00Z","timestamp":1300665600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["J Oncol Pharm Pract"],"published-print":{"date-parts":[[2012,3]]},"abstract":"<jats:p>Introduction. Breast cancer is no longer seen as a single disease but rather a multifaceted disease composed of distinct biological subtypes with diverse natural history, clinical, pathological, and molecular features. Recent attention has been directed at the molecular classification of breast cancer.<\/jats:p>\n                  <jats:p>Objective. To evaluate the prognostic value of triple-negative subtype in stage II\/III breast cancer and to define the role of clinical stage in prognosis of breast cancer.<\/jats:p>\n                  <jats:p>Methods. We used the immunohistochemical technique to divide 255 cases of breast cancer, stages II and III, into four subtypes according to estrogen receptor\/progesterone receptor and Her-2 expression.<\/jats:p>\n                  <jats:p>Results. Triple-negative subtype comprised 76.5% of the cases with 12.3% recurrence rate. Luminal A subtype also carried a poor outcome with 16.7% recurrence rate.<\/jats:p>\n                  <jats:p>Conclusion. Triple-negative subtype has the worst overall and disease-free survival in stage II\/III breast cancer. Clinical stage is still an independent prognostic factor in the breast cancers of all types.<\/jats:p>","DOI":"10.1177\/1078155211398299","type":"journal-article","created":{"date-parts":[[2011,3,22]],"date-time":"2011-03-22T00:30:11Z","timestamp":1300753811000},"page":"68-75","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["The prognostic value of triple negative in stage II\/III breast cancer"],"prefix":"10.1177","volume":"18","author":[{"given":"Afaf T","family":"Elnashar","sequence":"first","affiliation":[{"name":"Department of Pathology, Sohag University, Sohag, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"El-Sayed M","family":"Ali","sequence":"additional","affiliation":[{"name":"Department of Oncology, Sohag University, Sohag, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed","family":"Gaber","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Sohag University, Sohag, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2011,3,21]]},"reference":[{"key":"bibr1-1078155211398299","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyh414"},{"key":"bibr2-1078155211398299","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.243.14.1"},{"key":"bibr3-1078155211398299","unstructured":"El-Atar I. 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